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Epidermal barrier treatments based on vernix caseosa.
Visscher MO, Barai N, LaRuffa AA, Pickens WL, Narendran V, Hoath SB. Visscher MO, et al. Skin Pharmacol Physiol. 2011;24(6):322-9. doi: 10.1159/000328744. Epub 2011 Aug 4. Skin Pharmacol Physiol. 2011. PMID: 21822033
BACKGROUND/AIMS: Premature infants lack the vernix caseosa, have an incompetent stratum corneum (SC) barrier and are predisposed to infection. ...CONCLUSIONS: The findings suggest that vernix-based topical creams would be effective for the tr …
BACKGROUND/AIMS: Premature infants lack the vernix caseosa, have an incompetent stratum corneum (SC) barrier and are pr …
Applying a vernix caseosa based formulation accelerates skin barrier repair by modulating lipid biosynthesis.
Boiten WA, Berkers T, Absalah S, van Smeden J, Lavrijsen APM, Bouwstra JA. Boiten WA, et al. J Lipid Res. 2018 Feb;59(2):250-260. doi: 10.1194/jlr.M079186. Epub 2017 Dec 7. J Lipid Res. 2018. PMID: 29217624 Free PMC article.
Restoring the lipid homeostasis of the stratum corneum (SC) is a common strategy to enhance skin barrier function. Here, we used a ceramide containing vernix caseosa (VC)-based formulation and were able to accelerate barrier recovery in healthy …
Restoring the lipid homeostasis of the stratum corneum (SC) is a common strategy to enhance skin barrier function. Here, we used a ce …
Characterization of vernix caseosa as a natural biofilm: comparison to standard oil-based ointments.
Bautista MI, Wickett RR, Visscher MO, Pickens WL, Hoath SB. Bautista MI, et al. Pediatr Dermatol. 2000 Jul-Aug;17(4):253-60. doi: 10.1046/j.1525-1470.2000.01770.x. Pediatr Dermatol. 2000. PMID: 10990571 Clinical Trial.
Such infants have a structurally immature stratum corneum and lack a surface coating of vernix caseosa. In this study we examined the short-term effects of topical application of vernix caseosa to human skin and contrasted these effects with commonly u …
Such infants have a structurally immature stratum corneum and lack a surface coating of vernix caseosa. In this study we exami …
Water-handling properties of vernix caseosa and a synthetic analogue.
Tansirikongkol A, Visscher MO, Wickett RR. Tansirikongkol A, et al. J Cosmet Sci. 2007 Nov-Dec;58(6):651-62. J Cosmet Sci. 2007. PMID: 18305878
A naturally occurring barrier cream, vernix caseosa, is the viscous material synthesized by the sebaceous glands in the late gestational human fetus. ...Vernix films are semi-permeable, i.e., in the range that facilitates barrier repair. ...
A naturally occurring barrier cream, vernix caseosa, is the viscous material synthesized by the sebaceous glands in the …