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Mechanism of Emodin in the Treatment of Rheumatoid Arthritis.
Cheng L, Chen J, Rong X. Cheng L, et al. Evid Based Complement Alternat Med. 2022 Oct 3;2022:9482570. doi: 10.1155/2022/9482570. eCollection 2022. Evid Based Complement Alternat Med. 2022. PMID: 36225183 Free PMC article. Review.
Rheumatoid arthritis (RA) is a chronic, systemic, and autoimmune disease, and its main pathological changes are inflammatory cell infiltration accompanied by the secretion and accumulation of a variety of related cytokines, which induce the destruction of cartilage and bon …
Rheumatoid arthritis (RA) is a chronic, systemic, and autoimmune disease, and its main pathological changes are inflammatory cell inf …
Emodin alleviates arthritis pain through reducing spinal inflammation and oxidative stress.
Cheng DW, Yue YF, Chen CX, Hu YD, Tang Q, Xie M, Liu L, Li D, Zhu HL, Cheng ML. Cheng DW, et al. Mol Pain. 2022 Apr;18:17448069221146398. doi: 10.1177/17448069221146398. Mol Pain. 2022. PMID: 36474308 Free PMC article.
Spinal inflammation and oxidative stress contribute to arthritis pain and represent ideal targets for the treatment of arthritis pain. ...In summary, emodin treatment activates AMPK, suppresses NLRP3 inflammasome response, elevates antioxidant response, inhib …
Spinal inflammation and oxidative stress contribute to arthritis pain and represent ideal targets for the treatment of arthritis …
Emodin ameliorates rheumatoid arthritis by promoting neutrophil apoptosis and inhibiting neutrophil extracellular trap formation.
Zhu M, Yuan K, Lu Q, Zhu Q, Zhang S, Li X, Zhao L, Wang H, Luo G, Wang T, Huang G, Xu A. Zhu M, et al. Mol Immunol. 2019 Aug;112:188-197. doi: 10.1016/j.molimm.2019.05.010. Epub 2019 Jun 5. Mol Immunol. 2019. PMID: 31176198
In this study, we evaluated the effect of emodin on a murine adjuvant-induced arthritis (AA) model of RA in vivo and on neutrophil apoptosis and NETosis in vitro. ...Emodin promoted apoptosis and inhibited autophagy and NETosis in neutrophils. ...
In this study, we evaluated the effect of emodin on a murine adjuvant-induced arthritis (AA) model of RA in vivo and on neutro …
[Therapeutic mechanism of emodin for treatment of rheumatoid arthritis: a network pharmacology-based analysis].
Cao C, Zeng L, Rong X. Cao C, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2022 Jun 20;42(6):913-921. doi: 10.12122/j.issn.1673-4254.2022.06.16. Nan Fang Yi Ke Da Xue Xue Bao. 2022. PMID: 35790443 Free PMC article. Chinese.
OBJECTIVE: To investigate the therapeutic mechanism of emodin in the treatment of rheumatoid arthritis (RA) using a network pharmacology-based method and validate this mechanism in a fibroblast-like synovial cell line. ...Cell scratch experiment and flow cytometry d …
OBJECTIVE: To investigate the therapeutic mechanism of emodin in the treatment of rheumatoid arthritis (RA) using a network ph …
Therapeutic effect of emodin on collagen-induced arthritis in mice.
Zhu X, Zeng K, Qiu Y, Yan F, Lin C. Zhu X, et al. Inflammation. 2013 Dec;36(6):1253-9. doi: 10.1007/s10753-013-9663-6. Inflammation. 2013. PMID: 23729279
However, the effect of emodin on collagen-induced arthritis (CIA) has not yet been investigated. ...Emodin may be a promising potential therapeutic reagent for arthritis treatment....
However, the effect of emodin on collagen-induced arthritis (CIA) has not yet been investigated. ...Emodin may be a pro …
Emodin promotes the recovery of rheumatoid arthritis by regulating the crosstalk between macrophage subsets and synovial fibroblast subsets.
Cheng L, Rong X. Cheng L, et al. Animal Model Exp Med. 2024 Feb 18. doi: 10.1002/ame2.12387. Online ahead of print. Animal Model Exp Med. 2024. PMID: 38369605 Free article.
BACKGROUND: To study the relationships among emodin, synovial fibroblasts (FLSs), and macrophages (STMs) to provide guidance for the use of emodin in rheumatoid arthritis (RA) treatment. ...In vitro experimental methods such as enzyme linked immunosorbent ass …
BACKGROUND: To study the relationships among emodin, synovial fibroblasts (FLSs), and macrophages (STMs) to provide guidance for the …
[Emodin alleviates joint inflammation and bone erosion in rats with collagen-induced arthritis by inhibiting ferroptosis and degrading matrix metalloproteinases].
Zhou S, Yang W, Zeng L, Cao C, Yuan S, Rong X. Zhou S, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2023 Oct 20;43(10):1776-1781. doi: 10.12122/j.issn.1673-4254.2023.10.16. Nan Fang Yi Ke Da Xue Xue Bao. 2023. PMID: 37933654 Free PMC article. Chinese.
OBJECTIVE: To investigate the osteoprotective mechanism of emodin in light of the ferroptosis signaling pathway in a rat model of rheumatoid arthritis. METHODS: SD rat models of collagen-induced arthritis (CIA) were treated with methotrexate or low or high do …
OBJECTIVE: To investigate the osteoprotective mechanism of emodin in light of the ferroptosis signaling pathway in a rat model of rhe …
Emodin ameliorates ulcerative colitis by the flagellin-TLR5 dependent pathway in mice.
Luo S, Deng X, Liu Q, Pan Z, Zhao Z, Zhou L, Luo X. Luo S, et al. Int Immunopharmacol. 2018 Jun;59:269-275. doi: 10.1016/j.intimp.2018.04.010. Epub 2018 Apr 15. Int Immunopharmacol. 2018. PMID: 29669309
Emodin is an anthraquinone compound derived from Rheum officinale Baill. Several reports showed that emodin had efficacy on acute pancreatitis, keratitis, myocarditis, and rheumatoid arthritis. ...
Emodin is an anthraquinone compound derived from Rheum officinale Baill. Several reports showed that emodin had efficacy on ac …
Antiangiogenic properties of lichen secondary metabolites.
Ulus G. Ulus G. Phytother Res. 2021 Jun;35(6):3046-3058. doi: 10.1002/ptr.7023. Epub 2021 Feb 15. Phytother Res. 2021. PMID: 33587324 Review.
Angiogenesis, the growth of new vessels from pre-existing vessels, contributes to numerous diseases including cancer, arthritis, atherosclerosis, infectious, and immune disorders. Antiangiogenic therapy is a promising approach for the treatment of such diseases by inhibiti …
Angiogenesis, the growth of new vessels from pre-existing vessels, contributes to numerous diseases including cancer, arthritis, athe …
Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.
Shrimali D, Shanmugam MK, Kumar AP, Zhang J, Tan BK, Ahn KS, Sethi G. Shrimali D, et al. Cancer Lett. 2013 Dec 1;341(2):139-49. doi: 10.1016/j.canlet.2013.08.023. Epub 2013 Aug 17. Cancer Lett. 2013. PMID: 23962559 Review.
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural occurring anthraquinone derivative isolated from roots and barks of numerous plants, molds, and lichens. It is found as an active ingredient in different Chinese herbs including Rheum palmatum and Polygonam multi …
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural occurring anthraquinone derivative isolated from roots and barks of nume …
30 results