[Adverse effects and hemodynamic effects of nifedipine as a tocolytic]

J Gynecol Obstet Biol Reprod (Paris). 2015 Sep;44(7):614-20. doi: 10.1016/j.jgyn.2014.08.010. Epub 2014 Oct 3.
[Article in French]

Abstract

Objectives: To describe maternal and fetal adverse effects, in particular cardiorespiratory, of nifedipine as tocolytic, as well as effects on hemodynamic parameters.

Materials and methods: A retrospective evaluative study describing the use of nifedipine as tocolytic at CHU Sainte-Justine in Montreal. Demographic data as well as maternal blood pressure and adverse effects, and maternal and fetal heart rate were collected from medical records of women treated with nifedipine following our tocolysis protocol between January 1st 2004 and March 1st 2007.

Results: The medical records of 213 pregnant women were included in the study. Cardiorespiratory adverse effects were noted in 69 (32.4%); of these, 19 (8.9%) had serious cardiorespiratory adverse events, including 6 acute pulmonary edema or overload. Mean maternal systolic and diastolic blood pressures were significantly decreased and mean maternal and fetal heart rates were significantly increased after the bolus dose. Other adverse effects were reported for 100 (46.9%) women.

Conclusion: Nifedipine may cause cardiorespiratory adverse effects warranting a close monitoring.

Keywords: Adverse effects; Effets indésirables; Nifedipine; Nifédipine; Tocolyse; Tocolytic.

Publication types

  • English Abstract

MeSH terms

  • Blood Pressure / drug effects*
  • Drug-Related Side Effects and Adverse Reactions*
  • Female
  • Heart Rate / drug effects*
  • Heart Rate, Fetal / drug effects
  • Humans
  • Nifedipine / adverse effects*
  • Pregnancy
  • Pregnancy Complications / chemically induced*
  • Pulmonary Edema / chemically induced*
  • Quebec
  • Tocolytic Agents / adverse effects*

Substances

  • Tocolytic Agents
  • Nifedipine