Effects of fumaric acid esters on blood-brain barrier tight junction proteins.
Neurosci Lett. 2013.
PMID: 24076006
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Effects of fumaric acid esters on blood-brain barrier tight junction proteins.
Bénardais K, Pul R, Singh V, Skripuletz T, Lee DH, Linker RA, Gudi V, Stangel M.
Bénardais K, et al.
Neurosci Lett. 2013 Oct 25;555:165-70. doi: 10.1016/j.neulet.2013.09.038. Epub 2013 Sep 26.
Neurosci Lett. 2013.
PMID: 24076006
The blood-brain barrier (BBB) is composed of a network of tight junctions (TJ) which interconnect cerebral endothelial cells (EC). ...One pathway to modulate BBB integrity could be the induction of nuclear-factor (erythroid derived 2) related factor-2 …
The blood-brain barrier (BBB) is composed of a network of tight junctions (TJ) which interconnect cerebral endot …
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Dimethyl fumarate attenuates cerebral edema formation by protecting the blood-brain barrier integrity.
Kunze R, Urrutia A, Hoffmann A, Liu H, Helluy X, Pham M, Reischl S, Korff T, Marti HH.
Kunze R, et al.
Exp Neurol. 2015 Apr;266:99-111. doi: 10.1016/j.expneurol.2015.02.022. Epub 2015 Feb 25.
Exp Neurol. 2015.
PMID: 25725349
We aim to characterize how tissue hypoxia, together with oxidative stress and inflammation, leads to capillary dysfunction and breakdown of the blood-brain barrier (BBB). In a mouse stroke model we show that systemic treatment with dimethyl fumarate (DMF), an …
We aim to characterize how tissue hypoxia, together with oxidative stress and inflammation, leads to capillary dysfunction and breakdown of …
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