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55 results

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Page 1
Exercise effects on DNA methylation in EVL, CDKN2A (p14, ARF), and ESR1 in colon tissue from healthy men and women.
Duggan C, Yu M, Willbanks AR, Tapsoba JD, Wang CY, Grady WM, McTiernan A. Duggan C, et al. Epigenetics. 2022 Oct;17(10):1070-1079. doi: 10.1080/15592294.2021.1982512. Epub 2021 Oct 6. Epigenetics. 2022. PMID: 34550860 Free PMC article. Clinical Trial.
ESR1 methylation patterns differed by sex: women -10.58% (exercisers) +11.10% (controls); men +5.54% (exercisers), -8.16% (controls) (P=0.05), adjusting for BMI and age. There were no statistically significant changes in methylation patterns in any gene stratified by chang …
ESR1 methylation patterns differed by sex: women -10.58% (exercisers) +11.10% (controls); men +5.54% (exercisers), -8.16% (controls) …
Estrogen and progesterone-related gene variants and colorectal cancer risk in women.
Lin JH, Manson JE, Kraft P, Cochrane BB, Gunter MJ, Chlebowski RT, Zhang SM. Lin JH, et al. BMC Med Genet. 2011 May 31;12:78. doi: 10.1186/1471-2350-12-78. BMC Med Genet. 2011. PMID: 21627810 Free PMC article.
METHOD: We conducted a comprehensive evaluation of single nucleotide polymorphisms (SNPs) in genes encoding 3 hormone receptors (ESR1, ESR2, PGR) and 5 hormone synthesizers (CYP19A1 and CYP17A1, HSD17B1, HSD17B2, HSD17B4) among 427 women with incident colorectal cancer and …
METHOD: We conducted a comprehensive evaluation of single nucleotide polymorphisms (SNPs) in genes encoding 3 hormone receptors (ESR1 …
Prediction of potential mechanisms of rhubarb therapy for colorectal cancer based on network pharmacological analysis and molecular docking.
Yang F, Li X, Zhang Y, Ren Y, Zhang J, Xiao K. Yang F, et al. Medicine (Baltimore). 2024 Mar 22;103(12):e37477. doi: 10.1097/MD.0000000000037477. Medicine (Baltimore). 2024. PMID: 38518016 Free PMC article.
Among this study, main targets might be TP53, EGF, MYC, CASP3, JUN, PTGS2, HSP90AA1, MMP9, ESR1, PPARG. And 10 key elements might associate with them, such as aloe-emodin, beta-sitosterol, gallic acid, eupatin, emodin, physcion, cis-resveratrol, rhein, crysophanol, catechi …
Among this study, main targets might be TP53, EGF, MYC, CASP3, JUN, PTGS2, HSP90AA1, MMP9, ESR1, PPARG. And 10 key elements might ass …
SOX9, miR-495, miR-590-3p, and miR-320d were identified as chemoradiotherapy-sensitive genes and miRNAs in colorectal cancer patients based on a microarray dataset.
Du B, Wang T, Yang X, Wang J, Shi X, Wang X, Wu D, Feng L, Chen L, Zhang W. Du B, et al. Neoplasma. 2019 Jan 15;66(1):8-19. doi: 10.4149/neo_2018_170324N214. Epub 2018 Aug 9. Neoplasma. 2019. PMID: 30509082
A PPI network was established that contained striking nodes, including ITGA2, MYC, ESR1, and dihydropyrimidine dehydrogenase (DPYD), among which ESR1 was linked to MYC, and the two nodes were also highlighted in the TF-target regulation network. ...
A PPI network was established that contained striking nodes, including ITGA2, MYC, ESR1, and dihydropyrimidine dehydrogenase (DPYD), …
Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women.
Lin J, Zee RY, Liu KY, Zhang SM, Lee IM, Manson JE, Giovannucci E, Buring JE, Cook NR. Lin J, et al. Cancer Causes Control. 2010 Jun;21(6):897-908. doi: 10.1007/s10552-010-9518-5. Epub 2010 Feb 11. Cancer Causes Control. 2010. PMID: 20148360 Free PMC article.
We sought to determine whether the association may be under genetic control by evaluating genetic variation in estrogen receptors (ESR1 and ESR2), progesterone receptor (PGR), aromatase cytochrome 450 enzyme (CYP19A1), and 17 beta-hydroxysteroid dehydrogenase type 2 gene ( …
We sought to determine whether the association may be under genetic control by evaluating genetic variation in estrogen receptors (ESR1 …
Site specific genetic differences in colorectal cancer via Next-Generation-Sequencing using a multigene panel.
Rencuzogullari A, Bisgin A, Erdogan KE, Gumus S, Yalav O, Boga I, Sonmezler O, Eray IC. Rencuzogullari A, et al. Ann Ital Chir. 2023;94:605-611. Ann Ital Chir. 2023. PMID: 38131395
Formalin-fixed, paraffin-embedded tumor tissues were analyzed for actionable variants in 11 genes via NGS (EGFR, ALK, KRAS, NRAS, KIT, BRAF, PDGFRA, ERBB2, ERBB3, ESR1, and RAF1). RESULTS: Most of the primary tumors were in the rectum (49 patients; 46.2%) followed by the r …
Formalin-fixed, paraffin-embedded tumor tissues were analyzed for actionable variants in 11 genes via NGS (EGFR, ALK, KRAS, NRAS, KIT, BRAF, …
Genomic Landscape of Advanced Solid Tumors in Circulating Tumor DNA and Correlation With Tissue Sequencing: A Single Institution's Experience.
Gerratana L, Movarek M, Wehbe F, Katam N, Mahalingam D, Donahue J, Shah A, Chae YK, Mulcahy M, Tsarwhas D, Villaflor V, Kalyan A, Hussein M, Patel J, Chandra S, Platanias LC, Gradishar W, Cristofanilli M, Behdad A. Gerratana L, et al. JCO Precis Oncol. 2022 Jun;6:e2100289. doi: 10.1200/PO.21.00289. JCO Precis Oncol. 2022. PMID: 35772051
PIK3CA, ERBB2, BRCA1, and FGFR1 alterations were associated with breast cancer, and ESR1 mutations were exclusively detected in this tumor type. Colorectal cancer was characterized by alterations in KRAS and APC mutations, whereas KRAS, EGFR, PIK3CA, and BRAF mutations wer …
PIK3CA, ERBB2, BRCA1, and FGFR1 alterations were associated with breast cancer, and ESR1 mutations were exclusively detected in this …
Systematic Analysis of CXC Chemokine-Vascular Endothelial Growth Factor A Network in Colonic Adenocarcinoma from the Perspective of Angiogenesis.
Situ Y, Lu X, Cui Y, Xu Q, Deng L, Lin H, Shao Z, Chen J. Situ Y, et al. Biomed Res Int. 2022 Oct 4;2022:5137301. doi: 10.1155/2022/5137301. eCollection 2022. Biomed Res Int. 2022. PMID: 36246978 Free PMC article.
Moreover, many transcription factor targets of the CXC chemokine-VEGFA network in patients with COAD were identified: RELA, NFKB1, ZFP36, XBP1, HDAC2, SP1, ATF4, EP300, BRCA1, ESR1, HIF1A, EGR1, STAT3, and JUN. We further identified the top three miRNAs involved in regulat …
Moreover, many transcription factor targets of the CXC chemokine-VEGFA network in patients with COAD were identified: RELA, NFKB1, ZFP36, XB …
Concordant DNA methylation in synchronous colorectal carcinomas.
Konishi K, Shen L, Jelinek J, Watanabe Y, Ahmed S, Kaneko K, Kogo M, Takano T, Imawari M, Hamilton SR, Issa JP. Konishi K, et al. Cancer Prev Res (Phila). 2009 Sep;2(9):814-22. doi: 10.1158/1940-6207.CAPR-09-0054. Epub 2009 Sep 8. Cancer Prev Res (Phila). 2009. PMID: 19737982 Free PMC article.
As a test of this hypothesis, we evaluated the methylation status of eight genes (MINT1, 2, 31, MLH1, p16, p14, MGMT, and ESR1), as well as BRAF and KRAS mutations, in 57 multiple colorectal neoplasias (M-CRN) and compared these to 69 solitary colorectal cancers (S-CRC). . …
As a test of this hypothesis, we evaluated the methylation status of eight genes (MINT1, 2, 31, MLH1, p16, p14, MGMT, and ESR1), as w …
Genetic variation in insulin pathway genes and distal colorectal adenoma risk.
Levine AJ, Ihenacho U, Lee W, Figueiredo JC, Vandenberg DJ, Edlund CK, Davis BD, Stern MC, Haile RW. Levine AJ, et al. Int J Colorectal Dis. 2012 Dec;27(12):1587-95. doi: 10.1007/s00384-012-1505-8. Epub 2012 May 30. Int J Colorectal Dis. 2012. PMID: 22645077
In this study, we used a comprehensive tag single-nucleotide polymorphisms (SNPs) approach to define genetic variation in six insulin axis genes (IGF1, IGF2, IGFBP1, IGFBP3, IRS1, and IRS2) and three genes associated with estrogen signaling (ESR1, ESR2, and PGR). METHODS: …
In this study, we used a comprehensive tag single-nucleotide polymorphisms (SNPs) approach to define genetic variation in six insulin axis g …
55 results