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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1991 1
1992 1
1993 1
1994 2
1995 7
1996 2
1997 4
1998 2
1999 3
2000 2
2001 2
2003 4
2004 3
2005 2
2006 4
2007 5
2010 5
2011 4
2012 1
2013 4
2014 2
2015 4
2016 5
2017 3
2018 1
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2020 7
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2023 6
2024 0

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92 results

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Page 1
EphA8 is a prognostic marker for epithelial ovarian cancer.
Liu X, Xu Y, Jin Q, Wang W, Zhang S, Wang X, Zhang Y, Xu X, Huang J. Liu X, et al. Oncotarget. 2016 Apr 12;7(15):20801-9. doi: 10.18632/oncotarget.8018. Oncotarget. 2016. PMID: 26989075 Free PMC article.
High EphA8 protein level is an independent prognostic marker in EOC. We conclude that EphA8 acts as an oncogene in EOC development and progression. Detection of EphA8 expression could be a useful prognosis marker and targeting EphA8 represents a novel …
High EphA8 protein level is an independent prognostic marker in EOC. We conclude that EphA8 acts as an oncogene in EOC develop …
EphA8 inhibits cell apoptosis via AKT signaling and is associated with poor prognosis in breast cancer.
Wang GH, Ni K, Gu C, Huang J, Chen J, Wang XD, Ni Q. Wang GH, et al. Oncol Rep. 2021 Aug;46(2):183. doi: 10.3892/or.2021.8134. Epub 2021 Jul 19. Oncol Rep. 2021. PMID: 34278497
Moreover, knockdown of EphA8 expression increased the chemosensitivity of BC cells to paclitaxel. In conclusion, the results of the present study indicated that EphA8 may be a useful prognostic marker in BC and that knockdown of EphA8 may represent a novel st …
Moreover, knockdown of EphA8 expression increased the chemosensitivity of BC cells to paclitaxel. In conclusion, the results of the p …
EphA8 acts as an oncogene and contributes to poor prognosis in gastric cancer via regulation of ADAM10.
Wang Y, Zhou N, Li P, Wu H, Wang Q, Gao X, Wang X, Huang J. Wang Y, et al. J Cell Physiol. 2019 Nov;234(11):20408-20419. doi: 10.1002/jcp.28642. Epub 2019 Apr 26. J Cell Physiol. 2019. PMID: 31026069
EphA8 knockdown also decreased expression of the protease ADAM10 (a disintegrin and metalloproteinase domain-containing protein 10) and ADAM10-related protein AKT, suggesting an interaction between EphA8 and ADAM10. ...These dates suggest that EphA8 could be …
EphA8 knockdown also decreased expression of the protease ADAM10 (a disintegrin and metalloproteinase domain-containing protein 10) a …
EphA8 is a Prognostic Factor for Oral Tongue Squamous Cell Carcinoma.
Liu L, Wang X, Ge W. Liu L, et al. Med Sci Monit. 2018 Oct 9;24:7213-7222. doi: 10.12659/MSM.910909. Med Sci Monit. 2018. PMID: 30300334 Free PMC article.
Multivariate analysis indicated that EphA8 expression could serve as an independent prognostic factor in OTSCC. ...CONCLUSIONS EphA8 was highly expressed in OTSCC tissues and was significantly associated with poor prognosis of OTSCC....
Multivariate analysis indicated that EphA8 expression could serve as an independent prognostic factor in OTSCC. ...CONCLUSIONS Eph …
EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor.
Yoo S, Shin J, Park S. Yoo S, et al. Mol Cells. 2010 Jun;29(6):603-9. doi: 10.1007/s10059-010-0075-2. Epub 2010 May 22. Mol Cells. 2010. PMID: 20496116 Free article.
Analysis of EphA8 deletion mutants revealed that a juxtamembrane region in EphA8 is critically involved in endocytosis of EphA8-ephrinA5 complexes. ...More importantly, down-regulation of Tiam-1 resulted in inefficient endocytosis of EphA8-ephrinA5 com …
Analysis of EphA8 deletion mutants revealed that a juxtamembrane region in EphA8 is critically involved in endocytosis of E …
The EphA8 receptor induces sustained MAP kinase activation to promote neurite outgrowth in neuronal cells.
Gu C, Shim S, Shin J, Kim J, Park J, Han K, Park S. Gu C, et al. Oncogene. 2005 Jun 16;24(26):4243-56. doi: 10.1038/sj.onc.1208584. Oncogene. 2005. PMID: 15782114
Using various deletion mutants lacking specific intracytoplasmic regions, we confirm that the tyrosine kinase domain of EphA8 is important for inducing neurite outgrowth. However, the tyrosine kinase activity of EphA8 is not crucial for neurite outgrowth induction. …
Using various deletion mutants lacking specific intracytoplasmic regions, we confirm that the tyrosine kinase domain of EphA8 is impo …
The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner.
Gu C, Park S. Gu C, et al. Mol Cell Biol. 2001 Jul;21(14):4579-97. doi: 10.1128/MCB.21.14.4579-4597.2001. Mol Cell Biol. 2001. PMID: 11416136 Free PMC article.
Using a panel of EphA8 point mutants, we have demonstrated that EphA8 kinase activity does not correlate with its ability to promote cell attachment to fibronectin. ...Additionally, we found that EphA8 had associated PI 3-kinase activity and that the p110gamm …
Using a panel of EphA8 point mutants, we have demonstrated that EphA8 kinase activity does not correlate with its ability to p …
Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon.
Shim S, Kim Y, Shin J, Kim J, Park S. Shim S, et al. Mol Cell Biol. 2007 Mar;27(5):1614-30. doi: 10.1128/MCB.01429-06. Epub 2006 Dec 18. Mol Cell Biol. 2007. PMID: 17178831 Free PMC article.
Meis2 and Pbx2 synergistically bind the ephA8 regulatory sequence in vitro, and this interaction is critical for the transcriptional activation of a reporter construct bearing the ephA8 regulatory region in the presence of histone deacetylase inhibitor. ...These stu …
Meis2 and Pbx2 synergistically bind the ephA8 regulatory sequence in vitro, and this interaction is critical for the transcriptional …
miR-10a controls glioma migration and invasion through regulating epithelial-mesenchymal transition via EphA8.
Yan Y, Wang Q, Yan XL, Zhang Y, Li W, Tang F, Li X, Yang P. Yan Y, et al. FEBS Lett. 2015 Mar 12;589(6):756-65. doi: 10.1016/j.febslet.2015.02.005. Epub 2015 Feb 12. FEBS Lett. 2015. PMID: 25683004 Free article.
In this study, we demonstrate that microRNA-10a (miR-10a) promotes cell migration and invasion by negatively regulating the expression of Eph tyrosine kinase receptor A8 (EphA8). Ectopic expression of EphA8 counteracts the promotion of migration and invasion induced …
In this study, we demonstrate that microRNA-10a (miR-10a) promotes cell migration and invasion by negatively regulating the expression of Ep …
Engineering lacZ Reporter gene into an ephA8 bacterial artificial chromosome using a highly efficient bacterial recombination system.
Kim Y, Song E, Choi S, Park S. Kim Y, et al. J Biochem Mol Biol. 2007 Sep 30;40(5):656-61. doi: 10.5483/bmbrep.2007.40.5.656. J Biochem Mol Biol. 2007. PMID: 17927897
In this report, we describe an optimized method for generation of ephA8 BAC transgenic mice expressing the lacZ reporter gene under ephA8 regulatory sequences. First, we constructed a targeting vector that carries a 1.2 kb ephA8 DNA upstream of its first exon …
In this report, we describe an optimized method for generation of ephA8 BAC transgenic mice expressing the lacZ reporter gene under …
92 results