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Page 1
Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1.
Hernández G, Ramírez MJ, Minguillón J, Quiles P, Ruiz de Garibay G, Aza-Carmona M, Bogliolo M, Pujol R, Prados-Carvajal R, Fernández J, García N, López A, Gutiérrez-Enríquez S, Diez O, Benítez J, Salinas M, Teulé A, Brunet J, Radice P, Peterlongo P, Schindler D, Huertas P, Puente XS, Lázaro C, Pujana MÀ, Surrallés J. Hernández G, et al. Nat Commun. 2018 Mar 6;9(1):967. doi: 10.1038/s41467-018-03433-3. Nat Commun. 2018. PMID: 29511213 Free PMC article.
Therefore, uncovering additional components of this DNA repair pathway is of extreme importance for further understanding cancer development and therapeutic vulnerabilities. Here, we identify EDC4, a known component of processing-bodies and regulator of mRNA decappi …
Therefore, uncovering additional components of this DNA repair pathway is of extreme importance for further understanding cancer deve …
The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis.
Di Stefano B, Luo EC, Haggerty C, Aigner S, Charlton J, Brumbaugh J, Ji F, Rabano Jiménez I, Clowers KJ, Huebner AJ, Clement K, Lipchina I, de Kort MAC, Anselmo A, Pulice J, Gerli MFM, Gu H, Gygi SP, Sadreyev RI, Meissner A, Yeo GW, Hochedlinger K. Di Stefano B, et al. Cell Stem Cell. 2019 Nov 7;25(5):622-638.e13. doi: 10.1016/j.stem.2019.08.018. Epub 2019 Oct 3. Cell Stem Cell. 2019. PMID: 31588046 Free PMC article.
Enhancer of mRNA Decapping protein 4 (EDC4) interacts with replication protein a (RPA) and contributes to Cisplatin resistance in cervical Cancer by alleviating DNA damage.
Wu X, Zhong Y, Chen Q, Zhang X, Zhang H. Wu X, et al. Hereditas. 2020 Oct 14;157(1):41. doi: 10.1186/s41065-020-00154-w. Hereditas. 2020. PMID: 33054858 Free PMC article.
EDC4 overexpression reduced DNA damage caused by cisplatin and enhanced cell growth of cervical cancer cells. ...This study indicated that EDC4 or RPA may be novel targets to combat chemotherapy resistance in cervical cancer....
EDC4 overexpression reduced DNA damage caused by cisplatin and enhanced cell growth of cervical cancer cells. ...This study in …
The NBDY Microprotein Regulates Cellular RNA Decapping.
Na Z, Luo Y, Schofield JA, Smelyansky S, Khitun A, Muthukumar S, Valkov E, Simon MD, Slavoff SA. Na Z, et al. Biochemistry. 2020 Oct 27;59(42):4131-4142. doi: 10.1021/acs.biochem.0c00672. Epub 2020 Oct 15. Biochemistry. 2020. PMID: 33059440 Free PMC article.
In this work, we demonstrate that endogenous NBDY directly interacts with the human RNA decapping complex through EDC4 and DCP1A and localizes to P-bodies. Global profiling of RNA stability changes in NBDY knockout (KO) cells reveals dysregulated stability of more than 140 …
In this work, we demonstrate that endogenous NBDY directly interacts with the human RNA decapping complex through EDC4 and DCP1A and …
The RNA degradation pathway is involved in PPARα-modulated anti-oral tumorigenesis.
Chang NW, Huang YP. Chang NW, et al. Biomedicine (Taipei). 2019 Dec;9(4):27. doi: 10.1051/bmdcn/2019090427. Epub 2019 Nov 14. Biomedicine (Taipei). 2019. PMID: 31724941 Free PMC article.
BACKGROUND: The activation of peroxisome proliferator-activated receptor alpha (PPARalpha) has been shown to reprogram tumor metabolism and exhibits great potential for treating anti-oral tumorigenesis. ...CONCLUSION: Our findings suggest that the activation of PPARalpha t …
BACKGROUND: The activation of peroxisome proliferator-activated receptor alpha (PPARalpha) has been shown to reprogram tumor metabolism …
CCHCR1 interacts with EDC4, suggesting its localization in P-bodies.
Ling YH, Wong CC, Li KW, Chan KM, Boukamp P, Liu WK. Ling YH, et al. Exp Cell Res. 2014 Sep 10;327(1):12-23. doi: 10.1016/j.yexcr.2014.05.008. Epub 2014 May 21. Exp Cell Res. 2014. PMID: 24858563
Out of more than 100 co-immunoprecipitants identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS), the enhancer of mRNA-decapping protein 4 (EDC4), which is a processing body (P-body) component, was particularly found to be the major interacting partner of …
Out of more than 100 co-immunoprecipitants identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS), the enhancer of mRNA-dec …
Pooled CRISPR Screening Identifies P-Bodies as Repressors of Cancer Epithelial-Mesenchymal Transition.
Fang L, Zhang L, Wang M, He Y, Yang J, Huang Z, Tan Y, Fang K, Li J, Sun Z, Li Y, Tang Y, Liang W, Cui H, Zhu Q, Wu Z, Li Y, Hu Y, Chen W. Fang L, et al. Cancer Res. 2024 Mar 4;84(5):659-674. doi: 10.1158/0008-5472.CAN-23-1693. Cancer Res. 2024. PMID: 38190710
Epithelial-mesenchymal transition (EMT) is a fundamental cellular process frequently hijacked by cancer cells to promote tumor progression, especially metastasis. ...Here, we performed a pooled CRISPR screen analyzing the influence of 1,547 RNA-binding proteins on cell mot …
Epithelial-mesenchymal transition (EMT) is a fundamental cellular process frequently hijacked by cancer cells to promote tumor progre …
Genome-scale CRISPR screens identify host factors that promote human coronavirus infection.
Grodzki M, Bluhm AP, Schaefer M, Tagmount A, Russo M, Sobh A, Rafiee R, Vulpe CD, Karst SM, Norris MH. Grodzki M, et al. Genome Med. 2022 Jan 27;14(1):10. doi: 10.1186/s13073-022-01013-1. Genome Med. 2022. PMID: 35086559 Free PMC article.
Of note, host factors involved in cell cycle regulation were enriched in our screens as were several key components of the programmed mRNA decay pathway. The role of EDC4 and XRN1 in coronavirus replication in human small airway epithelial cells was verified. ...
Of note, host factors involved in cell cycle regulation were enriched in our screens as were several key components of the programmed mRNA d …
More than just an IκB kinase: the IKK complex coordinates mRNA stability and transcription.
Perkins ND. Perkins ND. EMBO J. 2018 Dec 14;37(24):e101084. doi: 10.15252/embj.2018101084. Epub 2018 Dec 3. EMBO J. 2018. PMID: 30509970 Free PMC article.
Recent work from Mikuda et al reveals a new and unexpected function for IKK in the regulation of mRNA stability. Through interacting with and phosphorylating EDC4, a key component of the mRNA decapping complex, IKK regulates P-body formation and the stability of numerous m …
Recent work from Mikuda et al reveals a new and unexpected function for IKK in the regulation of mRNA stability. Through interacting with an …
Sodium butyrate down-regulates tristetraprolin-mediated cyclin B1 expression independent of the formation of processing bodies.
Zheng XT, Xiao XQ, Dai JJ. Zheng XT, et al. Int J Biochem Cell Biol. 2015 Dec;69:241-8. doi: 10.1016/j.biocel.2015.11.002. Epub 2015 Nov 10. Int J Biochem Cell Biol. 2015. PMID: 26555753
Here, we demonstrate that treating HEK293T cells and the non-small-cell lung cancer cell line A549 with a high concentration of sodium butyrate reduces cyclin B1 expression. ...Surprisingly, the overexpression of tristetraprolin prevents the formation of processing bodies, …
Here, we demonstrate that treating HEK293T cells and the non-small-cell lung cancer cell line A549 with a high concentration of sodiu …
14 results