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HNF1B, EZH2 and ECI2 in prostate carcinoma. Molecular, immunohistochemical and clinico-pathological study.
Dundr P, Bártů M, Hojný J, Michálková R, Hájková N, Stružinská I, Krkavcová E, Hadravský L, Kleissnerová L, Kopejsková J, Hiep BQ, Němejcová K, Jakša R, Čapoun O, Řezáč J, Jirsová K, Franková V. Dundr P, et al. Sci Rep. 2020 Sep 1;10(1):14365. doi: 10.1038/s41598-020-71427-7. Sci Rep. 2020. PMID: 32873863 Free PMC article.
In PC, mutations of HNF1B gene were rare, but the methylation of its promotor was a common finding and was positively correlated with Gleason score and stage. The relationship between HNF1B and EZH2/ECI2 was equivocal, but EZH2 and ECI2 were positively correlated on …
In PC, mutations of HNF1B gene were rare, but the methylation of its promotor was a common finding and was positively correlated with Gleaso …
Establishment of a prognostic model for ovarian cancer based on mitochondrial metabolism-related genes.
Meng C, Sun Y, Liu G. Meng C, et al. Front Oncol. 2023 May 15;13:1144430. doi: 10.3389/fonc.2023.1144430. eCollection 2023. Front Oncol. 2023. PMID: 37256178 Free PMC article.
BACKGROUND: Mitochondrial metabolism and mitochondrial structure were found to be altered in high-grade serous ovarian cancer (HGSOC). ...Finally, a drug sensitivity analysis was made via the Drug Sensitivity in Cancer (GDSC) database. RESULTS: 436 HGSOC-rela …
BACKGROUND: Mitochondrial metabolism and mitochondrial structure were found to be altered in high-grade serous ovarian cancer …
PTGIS May Be a Predictive Marker for Ovarian Cancer by Regulating Fatty Acid Metabolism.
Wu X, Lu W, Xu C, Jiang C, Zhang W, Zhang D, Cui S, Zhuo Z, Cui Y, Mei H, Wang Y, Li C. Wu X, et al. Comput Math Methods Med. 2023 Feb 2;2023:2397728. doi: 10.1155/2023/2397728. eCollection 2023. Comput Math Methods Med. 2023. PMID: 36785673 Free PMC article.
Many studies have found that fatty acid metabolism is related to the occurrence and metastasis of cancers. Therefore, it is possible that fatty acid metabolism-related genes (FAMRG) affect the prognosis of ovarian cancer patients. ...CONCLUSION: PTGIS …
Many studies have found that fatty acid metabolism is related to the occurrence and metastasis of cancers. Therefore, it is po …
TGM2, HMGA2, FXYD3, and LGALS4 genes as biomarkers in acquired oxaliplatin resistance of human colorectal cancer: A systems biology approach.
Cheraghi-Shavi T, Jalal R, Minuchehr Z. Cheraghi-Shavi T, et al. PLoS One. 2023 Aug 3;18(8):e0289535. doi: 10.1371/journal.pone.0289535. eCollection 2023. PLoS One. 2023. PMID: 37535601 Free PMC article.
Acquired resistance to oxaliplatin is considered as the primary reason for failure in colorectal cancer (CRC) therapy. Identifying the underlying resistance mechanisms may improve CRC treatment. ...In the next step, two novel up-regulated hub genes including ECI2 an …
Acquired resistance to oxaliplatin is considered as the primary reason for failure in colorectal cancer (CRC) therapy. Identifying th …
Lipid degradation promotes prostate cancer cell survival.
Itkonen HM, Brown M, Urbanucci A, Tredwell G, Ho Lau C, Barfeld S, Hart C, Guldvik IJ, Takhar M, Heemers HV, Erho N, Bloch K, Davicioni E, Derua R, Waelkens E, Mohler JL, Clarke N, Swinnen JV, Keun HC, Rekvig OP, Mills IG. Itkonen HM, et al. Oncotarget. 2017 Jun 13;8(24):38264-38275. doi: 10.18632/oncotarget.16123. Oncotarget. 2017. PMID: 28415728 Free PMC article.
Here we show that Enoyl-CoA delta isomerase 2 (ECI2) is a novel AR-target that promotes prostate cancer cell survival. Increased ECI2 expression predicts mortality in prostate cancer patients (p = 0.0086). ...
Here we show that Enoyl-CoA delta isomerase 2 (ECI2) is a novel AR-target that promotes prostate cancer cell survival. Increas …
HNF1B expression regulates ECI2 gene expression, potentially serving a role in prostate cancer progression.
Dan C, Zhang H, Zeng W, Huang L, Gong X, Li H, Yang E, Wang L, Yao Q. Dan C, et al. Oncol Lett. 2019 Jan;17(1):1094-1100. doi: 10.3892/ol.2018.9677. Epub 2018 Nov 8. Oncol Lett. 2019. PMID: 30655870 Free PMC article.
Prostate cancer is the most common form of cancer in men, with increased incidence rates observed in older individuals. Prostate cancer is primarily driven via activation of the androgen receptor (AR), the principal transcriptional factor governing prostate …
Prostate cancer is the most common form of cancer in men, with increased incidence rates observed in older individuals. Prosta …
Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes.
Geisbrecht BV, Zhang D, Schulz H, Gould SJ. Geisbrecht BV, et al. J Biol Chem. 1999 Jul 30;274(31):21797-803. doi: 10.1074/jbc.274.31.21797. J Biol Chem. 1999. PMID: 10419495 Free article.
The potential roles for this monofunctional Delta(3),Delta(2)-enoyl-CoA isomerase in peroxisomal metabolism are discussed....
The potential roles for this monofunctional Delta(3),Delta(2)-enoyl-CoA isomerase in peroxisomal metabolism are discussed....