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Diabetes impairs hematopoietic stem cell mobilization by altering niche function.
Ferraro F, Lymperi S, Méndez-Ferrer S, Saez B, Spencer JA, Yeap BY, Masselli E, Graiani G, Prezioso L, Rizzini EL, Mangoni M, Rizzoli V, Sykes SM, Lin CP, Frenette PS, Quaini F, Scadden DT. Ferraro F, et al. Sci Transl Med. 2011 Oct 12;3(104):104ra101. doi: 10.1126/scitranslmed.3002191. Sci Transl Med. 2011. PMID: 21998408 Free PMC article.
Success with transplantation of autologous hematopoietic stem and progenitor cells (HSPCs) in patients depends on adequate collection of these cells after mobilization from the bone marrow niche by the cytokine granulocyte colony-stimulating factor (G- …
Success with transplantation of autologous hematopoietic stem and progenitor cells (HSPCs) in patients depends on adequate col …
Diabetes mellitus as a poor mobilizer condition.
Fadini GP, DiPersio JF. Fadini GP, et al. Blood Rev. 2018 May;32(3):184-191. doi: 10.1016/j.blre.2017.11.002. Epub 2017 Nov 8. Blood Rev. 2018. PMID: 29132746 Review.
This review summarizes the current experimental and clinical evidence that diabetes mellitus is a risk factor for poor mobilization. Diabetes causes a profound remodeling of the HSC niche, resulting in impaired release of HSCs. ...Underst …
This review summarizes the current experimental and clinical evidence that diabetes mellitus is a risk factor for poor mobi …