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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 1
1992 3
1993 4
1994 6
1995 6
1996 14
1997 23
1998 14
1999 12
2000 24
2001 24
2002 29
2003 30
2004 32
2005 26
2006 31
2007 42
2008 33
2009 37
2010 47
2011 32
2012 39
2013 42
2014 35
2015 35
2016 33
2017 33
2018 25
2019 30
2020 30
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2022 25
2023 28
2024 8

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796 results

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Page 1
A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling.
Castillo-Azofeifa D, Wald T, Reyes EA, Gallagher A, Schanin J, Vlachos S, Lamarche-Vane N, Bomidi C, Blutt S, Estes MK, Nystul T, Klein OD. Castillo-Azofeifa D, et al. Cell Stem Cell. 2023 Feb 2;30(2):188-206.e6. doi: 10.1016/j.stem.2022.12.008. Epub 2023 Jan 13. Cell Stem Cell. 2023. PMID: 36640764 Free PMC article.
RNA sequencing (RNA-seq) and genetic mouse models demonstrated that DLG1 regulates the cellular response to increased canonical Wnt ligands. This occurs via the transcriptional regulation of Arhgap31, a GTPase-activating protein that deactivates CDC42, an effector of the n …
RNA sequencing (RNA-seq) and genetic mouse models demonstrated that DLG1 regulates the cellular response to increased canonical Wnt l …
Differential expression of DLG1 as a common trait in different human diseases: an encouraging issue in molecular pathology.
Marziali F, Dizanzo MP, Cavatorta AL, Gardiol D. Marziali F, et al. Biol Chem. 2019 May 27;400(6):699-710. doi: 10.1515/hsz-2018-0350. Biol Chem. 2019. PMID: 30517074 Free article. Review.
Experimental data have mainly identified DLG1 as a tumor suppressor. An outstanding point for DLG1 protein is that altered DLG1 expression and DLG1 gene mutations were observed in different pathologies, including cancer and neurological and immunologic …
Experimental data have mainly identified DLG1 as a tumor suppressor. An outstanding point for DLG1 protein is that altered …
lncRNA DLG1-AS1 promotes cervical cancer cell gemcitabine resistance by regulating miR-16-5p/HDGF.
Zou MJ, Cheng XR, Liu RF. Zou MJ, et al. J Obstet Gynaecol Res. 2022 Jul;48(7):1836-1847. doi: 10.1111/jog.15245. Epub 2022 Apr 7. J Obstet Gynaecol Res. 2022. PMID: 35388952
AIM: To investigate the long non-coding RNA DLG1 Antisense RNA 1 (lncRNA DLG1-AS1) mechanism in cervical cancer cells with gemcitabine (GEM) resistance. ...Moreover, the tumor volume in nude mice in the DLG1-AS1 knockdown group decreased after GEM treatment. …
AIM: To investigate the long non-coding RNA DLG1 Antisense RNA 1 (lncRNA DLG1-AS1) mechanism in cervical cancer cells with gem …
Dlg1 deletion in microglia ameliorates chronic restraint stress induced mice depression-like behavior.
Li X, Peng Z, Jiang L, Zhang P, Yang P, Yuan Z, Cheng J. Li X, et al. Front Pharmacol. 2023 Feb 22;14:1124845. doi: 10.3389/fphar.2023.1124845. eCollection 2023. Front Pharmacol. 2023. PMID: 36909184 Free PMC article.
In contrast to the effect of Dlg1 in the LPS-induced mouse model, Dlg1 knockout had little effect on microglial density, but significantly decreased the number of activated microglia and reversed microglia morphological changes in mice challenged with CRS. Moreover, …
In contrast to the effect of Dlg1 in the LPS-induced mouse model, Dlg1 knockout had little effect on microglial density, but s …
Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice.
Peng Z, Li X, Li J, Dong Y, Gao Y, Liao Y, Yan M, Yuan Z, Cheng J. Peng Z, et al. Neurosci Bull. 2021 Dec;37(12):1671-1682. doi: 10.1007/s12264-021-00765-x. Epub 2021 Sep 6. Neurosci Bull. 2021. PMID: 34490521 Free PMC article.
However, little is known about the role of Dlg1 in microglia and the maintenance of central nervous system homeostasis. ...Moreover, using an inducible Dlg1 microglia-specific knockout (Dlg1(flox/flox); CX3CR1(CreER)) mouse line, we found that microglial D
However, little is known about the role of Dlg1 in microglia and the maintenance of central nervous system homeostasis. ...Moreover, …
DLG1-AS1 is activated by MYC and drives the proliferation and migration of hepatocellular carcinoma cells through miR-497-5p/SSRP1 axis.
Min J, Jin D, Zhang F, Kang Y, Qi Y, Du P. Min J, et al. Cancer Cell Int. 2021 Jan 6;21(1):16. doi: 10.1186/s12935-020-01667-0. Cancer Cell Int. 2021. PMID: 33407499 Free PMC article.
Besides, MYC induced the transcriptional activation of DLG1-AS1. MYC could facilitate HCC cellular processes by up-regulating DLG1-AS1. MiR-497-5p could interact with DLG1-AS1 in HCC cells. Down-regulation of miR-497-5p could reverse the impacts of DLG1
Besides, MYC induced the transcriptional activation of DLG1-AS1. MYC could facilitate HCC cellular processes by up-regulating DLG1
Dlg1 Maintains Dendritic Cell Function by Securing Voltage-Gated K(+) Channel Integrity.
Dong X, Wei L, Guo X, Yang Z, Wu C, Li P, Lu L, Qi H, Shi Y, Hu X, Wu L, Chen L, Liu W. Dong X, et al. J Immunol. 2019 Jun 1;202(11):3187-3197. doi: 10.4049/jimmunol.1900089. Epub 2019 Apr 26. J Immunol. 2019. PMID: 31028120 Free PMC article.
In this study, we reported that DC-specific knockout of discs large homologue 1 (Dlg1) resulted in a significantly reduced capacity to mediate Ab responses to both thymus-independent and thymus-dependent Ags in Dlg1 (fl/fl)Cd11c-Cre-GFP mice. ...Thus, Dlg1-de …
In this study, we reported that DC-specific knockout of discs large homologue 1 (Dlg1) resulted in a significantly reduced capacity t …
The DLG1-AS1/miR-497/YAP1 axis regulates papillary thyroid cancer progression.
Huang Y, Zhang K, Li Y, Dai Y, Zhao H. Huang Y, et al. Aging (Albany NY). 2020 Nov 16;12(22):23326-23336. doi: 10.18632/aging.104121. Epub 2020 Nov 16. Aging (Albany NY). 2020. PMID: 33197895 Free PMC article.
DLG1-AS1 functions as a competing endogenous RNA (ceRNA) for miR-497. ...Moreover, inhibition of miR-497 abrogated the inhibitory effects of DLG1-AS1 depletion on PTC cells. These findings demonstrate that the DLG1-AS1-miR-497-YAP1 axis promotes the growth an
DLG1-AS1 functions as a competing endogenous RNA (ceRNA) for miR-497. ...Moreover, inhibition of miR-497 abrogated the inhibitory eff
LncRNA DLG1-AS1 Promotes Cancer Cell Proliferation in Triple Negative Breast Cancer by Downregulating miR-203.
Li S. Li S. J Breast Cancer. 2020 Aug;23(4):343-354. doi: 10.4048/jbc.2020.23.e46. J Breast Cancer. 2020. PMID: 32908786 Free PMC article.
DLG1-AS1 overexpression mediated downregulation of miR-203, whereas miR-203 overexpression had no significant effects on DLG1-AS1 expression. ...TNBC cell migration was promoted by DLG1-AS1 overexpression and inhibited by miR-203 overexpression or DLG1
DLG1-AS1 overexpression mediated downregulation of miR-203, whereas miR-203 overexpression had no significant effects on DLG1-
DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2.
Rezi CK, Aslanyan MG, Diwan GD, Cheng T, Chamlali M, Junger K, Anvarian Z, Lorentzen E, Pauly KB, Afshar-Bahadori Y, Fernandes EFA, Qian F, Tosi S, Christensen ST, Pedersen SF, Strømgaard K, Russell RB, Miner JH, Mahjoub MR, Boldt K, Roepman R, Pedersen LB. Rezi CK, et al. bioRxiv [Preprint]. 2023 Dec 15:2023.11.10.566524. doi: 10.1101/2023.11.10.566524. bioRxiv. 2023. PMID: 37987012 Free PMC article. Preprint.
Conditional knockout of Dlg1 in mouse kidney caused ciliary elongation and cystogenesis, and cell-based proximity labelling proteomics and fluorescence microscopy showed alterations in the ciliary proteome upon loss of DLG1. Specifically, the retromer subunit SDCCAG …
Conditional knockout of Dlg1 in mouse kidney caused ciliary elongation and cystogenesis, and cell-based proximity labelling proteomic …
796 results