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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1956 1
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1988 3
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1994 1
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1997 2
1998 2
1999 3
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2006 95
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1,639 results

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Page 1
DIABLO: an integrative approach for identifying key molecular drivers from multi-omics assays.
Singh A, Shannon CP, Gautier B, Rohart F, Vacher M, Tebbutt SJ, Lê Cao KA. Singh A, et al. Bioinformatics. 2019 Sep 1;35(17):3055-3062. doi: 10.1093/bioinformatics/bty1054. Bioinformatics. 2019. PMID: 30657866 Free PMC article.
DIABLO is versatile, allowing for modular-based analyses and cross-over study designs. In two case studies, DIABLO identified both known and novel multi-omics biomarkers consisting of mRNAs, miRNAs, CpGs, proteins and metabolites. ...
DIABLO is versatile, allowing for modular-based analyses and cross-over study designs. In two case studies, DIABLO identified …
Potency and Selectivity of SMAC/DIABLO Mimetics in Solid Tumor Therapy.
Zhao XY, Wang XY, Wei QY, Xu YM, Lau ATY. Zhao XY, et al. Cells. 2020 Apr 18;9(4):1012. doi: 10.3390/cells9041012. Cells. 2020. PMID: 32325691 Free PMC article. Review.
The second mitochondria-derived activator of caspase (SMAC)/direct inhibitor of apoptosis protein (IAP)-binding protein with low pI (DIABLO) protein is an essential and endogenous antagonist of inhibitor of apoptosis proteins (IAPs). ...
The second mitochondria-derived activator of caspase (SMAC)/direct inhibitor of apoptosis protein (IAP)-binding protein with low pI (DIAB …
Smac/DIABLO and colon cancer.
Anguiano-Hernandez YM, Chartier A, Huerta S. Anguiano-Hernandez YM, et al. Anticancer Agents Med Chem. 2007 Jul;7(4):467-73. doi: 10.2174/187152007781058631. Anticancer Agents Med Chem. 2007. PMID: 17630921 Review.
The role of Smac/DIABLO in colorectal carcinogenesis is ill defined. Data continues to accumulate to suggest that decreased levels of Smac/DIABLO may be important in chemoradiation-resistance to apoptosis in advanced colon cancer. The aim of this review is to provid …
The role of Smac/DIABLO in colorectal carcinogenesis is ill defined. Data continues to accumulate to suggest that decreased levels of …
Role of Smac/DIABLO in cancer progression.
Martinez-Ruiz G, Maldonado V, Ceballos-Cancino G, Grajeda JP, Melendez-Zajgla J. Martinez-Ruiz G, et al. J Exp Clin Cancer Res. 2008 Sep 26;27(1):48. doi: 10.1186/1756-9966-27-48. J Exp Clin Cancer Res. 2008. PMID: 18822137 Free PMC article. Review.
In the cytosol, Smac/DIABLO interacts and antagonizes inhibitors of apoptosis proteins (IAPs), thus allowing the activation of caspases and apoptosis. ...The objective of this review is to present the current knowledge of the Smac/DIABLO role in cancer and its possi …
In the cytosol, Smac/DIABLO interacts and antagonizes inhibitors of apoptosis proteins (IAPs), thus allowing the activation of caspas …
SMAC/Diablo controls proliferation of cancer cells by regulating phosphatidylethanolamine synthesis.
Pandey SK, Paul A, Shteinfer-Kuzmine A, Zalk R, Bunz U, Shoshan-Barmatz V. Pandey SK, et al. Mol Oncol. 2021 Nov;15(11):3037-3061. doi: 10.1002/1878-0261.12959. Epub 2021 May 4. Mol Oncol. 2021. PMID: 33794068 Free PMC article.
SMAC/Diablo, a pro-apoptotic protein, yet it is overexpressed in several cancer types. We have described a noncanonical function for SMAC/Diablo as a regulator of lipid synthesis during cancer cell proliferation and development. ...
SMAC/Diablo, a pro-apoptotic protein, yet it is overexpressed in several cancer types. We have described a noncanonical function for …
Mechanisms of caspase activation and inhibition during apoptosis.
Shi Y. Shi Y. Mol Cell. 2002 Mar;9(3):459-70. doi: 10.1016/s1097-2765(02)00482-3. Mol Cell. 2002. PMID: 11931755 Free article. Review.
Recent structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome have revealed a conserved mechanism of caspase activation and inhibition. ...
Recent structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome have revealed a conserved mechanism of ca …
Is there something else besides the proapoptotic AVPI-segment in the Smac/DIABLO protein?
Victoria-Acosta G, Martínez-Archundia M, Moreno-Vargas L, Meléndez-Zajgla J, Martínez-Ruiz GU. Victoria-Acosta G, et al. Bol Med Hosp Infant Mex. 2016 Nov-Dec;73(6):365-371. doi: 10.1016/j.bmhimx.2016.10.004. Epub 2016 Nov 30. Bol Med Hosp Infant Mex. 2016. PMID: 29421280 Free article. Review.
A key regulation mechanism is mediated by the Inhibitor of Apoptosis Proteins (IAPs) family members, which inhibit the activated forms of caspases through physical interaction with them. Smac/DIABLO, a mitochondrial protein that is translocated to the cytoplasm in apoptoti …
A key regulation mechanism is mediated by the Inhibitor of Apoptosis Proteins (IAPs) family members, which inhibit the activated forms of ca …
Coexpression of Smac/DIABLO and Estrogen Receptor in breast cancer.
Espinosa M, Lizárraga F, Vázquez-Santillán K, Hidalgo-Miranda A, Piña-Sánchez P, Torres J, García-Ramírez RA, Maldonado V, Melendez-Zajgla J, Ceballos-Cancino G. Espinosa M, et al. Cancer Biomark. 2021;30(4):429-446. doi: 10.3233/CBM-200535. Cancer Biomark. 2021. PMID: 33492282
In vitro assays were performed to investigate possible regulators of Smac/DIABLO. RESULTS: Higher levels of Smac/DIABLO mRNA and protein were found in estrogen receptor (ER)-positive samples (p= 0.0054 and p= 0.0043, respectively) in comparison to ER-negative tumors …
In vitro assays were performed to investigate possible regulators of Smac/DIABLO. RESULTS: Higher levels of Smac/DIABLO mRNA a …
Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology.
Shiozaki EN, Shi Y. Shiozaki EN, et al. Trends Biochem Sci. 2004 Sep;29(9):486-94. doi: 10.1016/j.tibs.2004.07.003. Trends Biochem Sci. 2004. PMID: 15337122 Review.
The activated caspases are subject to inhibition by the inhibitor of apoptosis family of proteins. This inhibition can be removed by Smac/DIABLO during apoptosis. The underlying molecular mechanisms of caspase regulation are discussed in this article....
The activated caspases are subject to inhibition by the inhibitor of apoptosis family of proteins. This inhibition can be removed by Smac/ …
Diablo ubiquitination analysis by sandwich immunoassay.
Guven A, Wu WS, Patil S, Gokul K, Tekumalla P, Sharma S, Diers A, Gesta S, Vishnudas V, Sarangarajan R, Kellogg MD, Narain NR, Kiebish MA. Guven A, et al. J Pharm Biomed Anal. 2019 Sep 5;173:40-46. doi: 10.1016/j.jpba.2019.05.005. Epub 2019 May 3. J Pharm Biomed Anal. 2019. PMID: 31108422
In efforts to identify IAP inhibitors, we developed sandwich immunoassays in conjunction with an electrochemical luminescence (ECL) platform for quantitation of total Diablo, ubiquitinated Diablo, and ubiquitinated Diablo with K48-specific linkage. The assay …
In efforts to identify IAP inhibitors, we developed sandwich immunoassays in conjunction with an electrochemical luminescence (ECL) platform …
1,639 results