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24 results

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Page 1
Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma.
Hu L, Zhang Y, Guo L, Zhong H, Xie L, Zhou J, Liao C, Yao H, Fang J, Liu H, Zhang C, Zhang H, Zhu X, Luo M, von Kriegsheim A, Li B, Luo W, Zhang X, Chen X, Mendell JT, Xu L, Kapur P, Baldwin AS, Brugarolas J, Zhang Q. Hu L, et al. Mol Cell. 2024 Feb 15;84(4):776-790.e5. doi: 10.1016/j.molcel.2023.12.010. Epub 2024 Jan 10. Mol Cell. 2024. PMID: 38211588
In this study, we perform a kinome-wide small interfering RNA (siRNA) screen and identify doublecortin-like kinase 2 (DCLK2) as a TBK1 regulator in ccRCC. DCLK2 binds to and directly phosphorylates TBK1 on Ser172. ...Mechanistically, DCLK2(203) elicits its on …
In this study, we perform a kinome-wide small interfering RNA (siRNA) screen and identify doublecortin-like kinase 2 (DCLK2) as a TBK …
Multiple asters organize the yolk microtubule network during dclk2-GFP zebrafish epiboly.
Marsal M, Bernardello M, Gualda EJ, Loza-Alvarez P. Marsal M, et al. Sci Rep. 2022 Mar 8;12(1):4072. doi: 10.1038/s41598-022-07747-7. Sci Rep. 2022. PMID: 35260695 Free PMC article.
In this work, we use Light Sheet Fluorescence and Confocal Microscopy to investigate how the MT network surrounding the spherical yolk is arranged in the dclk2-GFP zebrafish transgenic line. We found that during epiboly the MT network is organized by multiple aster-like MT …
In this work, we use Light Sheet Fluorescence and Confocal Microscopy to investigate how the MT network surrounding the spherical yolk is ar …
Doublecortin-like kinase 2 promotes breast cancer cell invasion and metastasis.
He Y, Dai X, Li S, Zhang X, Gong K, Song K, Shi J. He Y, et al. Clin Transl Oncol. 2023 Apr;25(4):1102-1113. doi: 10.1007/s12094-022-03018-z. Epub 2022 Dec 8. Clin Transl Oncol. 2023. PMID: 36477947
METHODS: DCLK2 overexpression and knockdown clones were established by lentivirus transfection. ...CONCLUSION: Our study indicates that DCLK2 plays an important role in EMT, cell invasion and metastasis, suggesting that DCLK2 is a potential target for the tre …
METHODS: DCLK2 overexpression and knockdown clones were established by lentivirus transfection. ...CONCLUSION: Our study indicates th …
Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf.
Sun M, Huang X, Ruan X, Shang X, Zhang M, Liu L, Wang P, An P, Lin Y, Yang J, Xue Y. Sun M, et al. J Cereb Blood Flow Metab. 2024 Mar 21:271678X241240590. doi: 10.1177/0271678X241240590. Online ahead of print. J Cereb Blood Flow Metab. 2024. PMID: 38513137
This study aimed to explore whether the interaction between RBP-Cpeb4 and Dclk2 affected Ehf phosphorylation to regulate neuronal pyroptosis. ...Cpeb4 upregulated Dclk2 expression by increasing Dclk2 mRNA stability. Knockdown of Cpeb4 or Dclk2 inhibite …
This study aimed to explore whether the interaction between RBP-Cpeb4 and Dclk2 affected Ehf phosphorylation to regulate neuronal pyr …
Tissue-specific regulation of gene expression via unproductive splicing.
Mironov A, Petrova M, Margasyuk S, Vlasenok M, Mironov AA, Skvortsov D, Pervouchine DD. Mironov A, et al. Nucleic Acids Res. 2023 Apr 24;51(7):3055-3066. doi: 10.1093/nar/gkad161. Nucleic Acids Res. 2023. PMID: 36912101 Free PMC article.
Among them, we found previously unknown PTBP1-controlled events in the DCLK2 and IQGAP1 genes, for which we confirmed the regulatory effect using small interfering RNA (siRNA) knockdown experiments in the A549 cell line. ...
Among them, we found previously unknown PTBP1-controlled events in the DCLK2 and IQGAP1 genes, for which we confirmed the regulatory …
Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice.
Tuy FP, Saillour Y, Kappeler C, Chelly J, Francis F. Tuy FP, et al. Dev Neurosci. 2008;30(1-3):171-86. doi: 10.1159/000109861. Dev Neurosci. 2008. PMID: 18075264
However, a minor change in expression at the protein level was detected. The Dclk2 gene is less well characterized than Dclk1 and we show here that it is expressed both in proliferating cells and postmitotic neurons, with a notably strong expression in the ventral telencep …
However, a minor change in expression at the protein level was detected. The Dclk2 gene is less well characterized than Dclk1 and we …
Analysis of retrotransposon subfamily DNA methylation reveals novel early epigenetic changes in chronic lymphocytic leukemia.
Barrow TM, Wong Doo N, Milne RL, Giles GG, Willmore E, Strathdee G, Byun HM. Barrow TM, et al. Haematologica. 2021 Jan 1;106(1):98-110. doi: 10.3324/haematol.2019.228478. Haematologica. 2021. PMID: 31919093 Free PMC article.
Locus-specific hypomethylation was associated with differential expression of proximal genes, including DCLK2, HK1, ILRUN, TANK, TBCD, TNFRSF1B and TXNRD2, with higher expression of DCLK2 and TNFRSF1B associated with reduced patient survival. ...
Locus-specific hypomethylation was associated with differential expression of proximal genes, including DCLK2, HK1, ILRUN, TANK, TBCD …
Epilepsy associated with autism and attention deficit hyperactivity disorder: is there a genetic link?
Lo-Castro A, Curatolo P. Lo-Castro A, et al. Brain Dev. 2014 Mar;36(3):185-93. doi: 10.1016/j.braindev.2013.04.013. Epub 2013 May 29. Brain Dev. 2014. PMID: 23726375 Review.
The majority of the candidate genes are involved in synaptic formation/remodeling/maintenance (NRX1, CNTN4, DCLK2, CNTNAP2, TRIM32, ASTN2, CTNTN5, SYN1), neurotransmission (SYNGAP1, GABRG1, CHRNA7), or DNA methylation/chromatin remodeling (MBD5). ...
The majority of the candidate genes are involved in synaptic formation/remodeling/maintenance (NRX1, CNTN4, DCLK2, CNTNAP2, TRIM32, A …
Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis.
Mueller SH, Färber A, Prüss H, Melzer N, Golombeck KS, Kümpfel T, Thaler F, Elisak M, Lewerenz J, Kaufmann M, Sühs KW, Ringelstein M, Kellinghaus C, Bien CG, Kraft A, Zettl UK, Ehrlich S, Handreka R, Rostásy K, Then Bergh F, Faiss JH, Lieb W, Franke A, Kuhlenbäumer G, Wandinger KP, Leypoldt F; German Network for Research on Autoimmune Encephalitis (GENERATE). Mueller SH, et al. Ann Neurol. 2018 Apr;83(4):863-869. doi: 10.1002/ana.25216. Ann Neurol. 2018. PMID: 29572931
Potential associations, below genome-wide significance, were found with rs72961463 close to the doublecortin-like kinase 2 gene (DCLK2) and rs62110161 in a cluster of zinc-finger genes. HLA allele imputation identified association of anti-LGI1 encephalitis with HLA-II hapl …
Potential associations, below genome-wide significance, were found with rs72961463 close to the doublecortin-like kinase 2 gene (DCLK2 …
Genetics of resilience: Implications from genome-wide association studies and candidate genes of the stress response system in posttraumatic stress disorder and depression.
Maul S, Giegling I, Fabbri C, Corponi F, Serretti A, Rujescu D. Maul S, et al. Am J Med Genet B Neuropsychiatr Genet. 2020 Mar;183(2):77-94. doi: 10.1002/ajmg.b.32763. Epub 2019 Oct 4. Am J Med Genet B Neuropsychiatr Genet. 2020. PMID: 31583809 Review.
A recently published genome-wide association study (GWAS) on resilience has identified three new susceptibility loci, DCLK2, KLHL36, and SLC15A5. Further interesting results can be found in association analyses of gene variants of the stress response system, which is close …
A recently published genome-wide association study (GWAS) on resilience has identified three new susceptibility loci, DCLK2, KLHL36, …
24 results