Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immunomodulatory conditions

J Infect Dis. 2010 Nov 15;202(10):1478-81. doi: 10.1086/657168. Epub 2010 Oct 11.

Abstract

We investigated the prevalence of xenotropic murine leukemia virus-related virus (XMRV) among 293 participants seen at academic hospitals in Boston, Massachusetts. Participants were recruited from the following 5 groups of patients: chronic fatigue syndrome (n = 32), human immunodeficiency virus infection (n = 43), rheumatoid arthritis (n = 97), hematopoietic stem-cell or solid organ transplant (n = 26), or a general cohort of patients presenting for medical care (n = 95). XMRV DNA was not detected in any participant samples. We found no association between XMRV and patients with chronic fatigue syndrome or chronic immunomodulatory conditions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Arthritis, Rheumatoid / immunology
  • Arthritis, Rheumatoid / virology
  • Cohort Studies
  • Cross-Sectional Studies
  • DNA, Viral / genetics
  • Fatigue Syndrome, Chronic / epidemiology
  • Fatigue Syndrome, Chronic / virology*
  • Female
  • HIV Infections / immunology
  • HIV Infections / virology
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Immunocompromised Host*
  • Leukemia Virus, Murine / genetics
  • Leukemia Virus, Murine / isolation & purification*
  • Male
  • Massachusetts / epidemiology
  • Middle Aged
  • Organ Transplantation
  • Polymerase Chain Reaction
  • Retroviridae Infections / epidemiology*
  • Transplantation Immunology
  • Tumor Virus Infections / epidemiology*

Substances

  • DNA, Viral