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Conservation and immunogenicity of the mosquito ortholog of the tick-protective antigen, subolesin.
Canales M, Naranjo V, Almazán C, Molina R, Tsuruta SA, Szabó MP, Manzano-Roman R, Pérez de la Lastra JM, Kocan KM, Jiménez MI, Lucientes J, Villar M, de la Fuente J. Canales M, et al. Parasitol Res. 2009 Jul;105(1):97-111. doi: 10.1007/s00436-009-1368-2. Epub 2009 Feb 21. Parasitol Res. 2009. PMID: 19229557
The control of arthropod vectors of pathogens that affect human and animal health is important for the eradication of vector-borne diseases. The ortholog of the tick-protective antigen, subolesin, was identified in Aedes albopictus and found to have conserved epitop …
The control of arthropod vectors of pathogens that affect human and animal health is important for the eradication of vector-borne diseases. …
Gene cloning, expression and immunogenicity of the protective antigen subolesin in Dermacentor silvarum.
Hu Y, Zeng H, Zhang J, Wang D, Li D, Zhang T, Yang S, Liu J. Hu Y, et al. Korean J Parasitol. 2014 Feb;52(1):93-7. doi: 10.3347/kjp.2014.52.1.93. Epub 2014 Feb 19. Korean J Parasitol. 2014. PMID: 24623890 Free PMC article.
Subolesin (4D8), the ortholog of insect akirins, is a highly conserved protective antigen and thus has the potential for development of a broad-spectrum vaccine against ticks and mosquitoes. To date, no protective antigens have been characterized nor t …
Subolesin (4D8), the ortholog of insect akirins, is a highly conserved protective antigen and thus has the potential for devel …
Mapping protective epitopes in the tick and mosquito subolesin ortholog proteins.
Prudencio CR, Pérez de la Lastra JM, Canales M, Villar M, de la Fuente J. Prudencio CR, et al. Vaccine. 2010 Jul 26;28(33):5398-406. doi: 10.1016/j.vaccine.2010.06.021. Epub 2010 Jun 19. Vaccine. 2010. PMID: 20594626
The tick protective antigen, subolesin, is a structural and functional ortholog of insect akirins, an evolutionary conserved group of proteins that regulate gene expression thus affecting multiple cellular processes such as digestion, immune response, reproduction a …
The tick protective antigen, subolesin, is a structural and functional ortholog of insect akirins, an evolutionary conserved g …
Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites.
Swearingen KE, Lindner SE, Flannery EL, Vaughan AM, Morrison RD, Patrapuvich R, Koepfli C, Muller I, Jex A, Moritz RL, Kappe SHI, Sattabongkot J, Mikolajczak SA. Swearingen KE, et al. PLoS Negl Trop Dis. 2017 Jul 31;11(7):e0005791. doi: 10.1371/journal.pntd.0005791. eCollection 2017 Jul. PLoS Negl Trop Dis. 2017. PMID: 28759593 Free PMC article.
Quantitative comparison of the P. vivax and P. falciparum salivary gland sporozoite proteomes revealed a high degree of similarity in protein expression levels, including among invasion-related proteins. Nevertheless, orthologs with significantly different expression level …
Quantitative comparison of the P. vivax and P. falciparum salivary gland sporozoite proteomes revealed a high degree of similarity in protei …
Transmission-blocking vaccine of vivax malaria.
Tsuboi T, Tachibana M, Kaneko O, Torii M. Tsuboi T, et al. Parasitol Int. 2003 Mar;52(1):1-11. doi: 10.1016/s1383-5769(02)00037-5. Parasitol Int. 2003. PMID: 12543142 Review.
The genes coding for two potential P. vivax transmission-blocking antigens, Pvs25 and Pvs28, have been cloned. Mice vaccinated with yeast-produced recombinant proteins Pvs25 and Pvs28 adsorbed to aluminum hydroxide developed strong antibody responses against the immunog …
The genes coding for two potential P. vivax transmission-blocking antigens, Pvs25 and Pvs28, have been cloned. Mice vaccinated with y …
Expression and localization of rhoptry neck protein 5 in merozoites and sporozoites of Plasmodium yoelii.
Mutungi JK, Yahata K, Sakaguchi M, Kaneko O. Mutungi JK, et al. Parasitol Int. 2014 Dec;63(6):794-801. doi: 10.1016/j.parint.2014.07.013. Epub 2014 Aug 4. Parasitol Int. 2014. PMID: 25102354
In this study, Plasmodium yoelii RON5 gene (pyron5) was identified as an ortholog of P. falciparum and Plasmodium berghei ron5. The pyron5 exon-intron structure was validated by comparing genomic DNA sequences and experimentally determining full-length complementary DNA se …
In this study, Plasmodium yoelii RON5 gene (pyron5) was identified as an ortholog of P. falciparum and Plasmodium berghei ron5. The p …
Investigation of Heterochromatin Protein 1 Function in the Malaria Parasite Plasmodium falciparum Using a Conditional Domain Deletion and Swapping Approach.
Bui HTN, Passecker A, Brancucci NMB, Voss TS. Bui HTN, et al. mSphere. 2021 Feb 3;6(1):e01220-20. doi: 10.1128/mSphere.01220-20. mSphere. 2021. PMID: 33536327 Free PMC article.
Finally, we discovered that the hinge domain and CSD of HP1 are functionally conserved between P. falciparum and P. berghei, a related malaria parasite infecting rodents. ...Some blood-stage parasites exit the cell cycle and differentiate into gametocytes that are essentia …
Finally, we discovered that the hinge domain and CSD of HP1 are functionally conserved between P. falciparum and P. berghei, a relate …
Anthrax toxin component, Protective Antigen, protects insects from bacterial infections.
Alameh S, Bartolo G, O'Brien S, Henderson EA, Gonzalez LO, Hartmann S, Klimko CP, Shoe JL, Cote CK, Grill LK, Levitin A, Martchenko Shilman M. Alameh S, et al. PLoS Pathog. 2020 Aug 31;16(8):e1008836. doi: 10.1371/journal.ppat.1008836. eCollection 2020 Aug. PLoS Pathog. 2020. PMID: 32866212 Free PMC article.
In mammals, a secreted anthrax toxin component, 83 kDa Protective Antigen (PA83), binds to cell-surface receptors and is cleaved by furin into an evolutionary-conserved PA20 and a pore-forming PA63 subunits. We show that PA20 increases the resistance of Drosophila flies an …
In mammals, a secreted anthrax toxin component, 83 kDa Protective Antigen (PA83), binds to cell-surface receptors and is cleaved by furin in …
Inhibition of immune pathway-initiating hemolymph protease-14 by Manduca sexta serpin-12, a conserved mechanism for the regulation of melanization and Toll activation in insects.
Wang Y, Yang F, Cao X, Huang R, Paskewitz S, Hartson SD, Kanost MR, Jiang H. Wang Y, et al. Insect Biochem Mol Biol. 2020 Jan;116:103261. doi: 10.1016/j.ibmb.2019.103261. Epub 2019 Nov 4. Insect Biochem Mol Biol. 2020. PMID: 31698082 Free PMC article.
Here we present evidence that these responses are initiated through a conserved serine protease and negatively regulated by serpins in two species, Manduca sexta and Anopheles gambiae. ...Guided by the results of phylogenetic analysis, we cloned and expressed A. gambiae pr …
Here we present evidence that these responses are initiated through a conserved serine protease and negatively regulated by serpins i …
Subolesin/akirin orthologs from Ornithodoros spp. soft ticks: cloning, RNAi gene silencing and protective effect of the recombinant proteins.
Manzano-Román R, Díaz-Martín V, Oleaga A, Siles-Lucas M, Pérez-Sánchez R. Manzano-Román R, et al. Vet Parasitol. 2012 Apr 30;185(2-4):248-59. doi: 10.1016/j.vetpar.2011.10.032. Epub 2011 Oct 29. Vet Parasitol. 2012. PMID: 22105082
Soft ticks could be also targeted by this vaccine if proved that the soft tick subolesin orthologs are conserved and induce protective immune responses too. However, to date no soft tick subolesin orthologs have been fully characterized nor tested as recombin …
Soft ticks could be also targeted by this vaccine if proved that the soft tick subolesin orthologs are conserved and induce pr …
11 results