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Year Number of Results
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1992 3
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1994 3
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1997 2
1999 3
2000 1
2001 2
2002 3
2003 3
2004 1
2005 1
2006 2
2007 2
2008 1
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2011 3
2012 5
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183 results

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Page 1
CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1.
Li D, Wang Y, Dong C, Chen T, Dong A, Ren J, Li W, Shu G, Yang J, Shen W, Qin L, Hu L, Zhou J. Li D, et al. Oncogene. 2023 Jan;42(2):83-98. doi: 10.1038/s41388-022-02537-x. Epub 2022 Nov 12. Oncogene. 2023. PMID: 36369321 Free PMC article.
In this study, we explored the role of cysteine protease inhibitor SN (Cystatin SN, CST1) in promoting gastric cancer metastasis. We hypothesized that CST1 could regulate gastric cancer progression by regulating GPX4 and ferroptosis. Whole transcriptome sequencing s …
In this study, we explored the role of cysteine protease inhibitor SN (Cystatin SN, CST1) in promoting gastric cancer metastasis. We …
Transcriptomic analysis of asthma and allergic rhinitis reveals CST1 as a biomarker of unified airways.
Wang M, Gong L, Luo Y, He S, Zhang X, Xie X, Li X, Feng X. Wang M, et al. Front Immunol. 2023 Jan 17;14:1048195. doi: 10.3389/fimmu.2023.1048195. eCollection 2023. Front Immunol. 2023. PMID: 36733482 Free PMC article.
According to the ROC curve, CST1 showed excellent diagnostic efficiency for Th2-high asthma. GSEA indicated that CST1 was involved in the FcRI signaling pathway and O-glycan biosynthesis. ...
According to the ROC curve, CST1 showed excellent diagnostic efficiency for Th2-high asthma. GSEA indicated that CST1 was invo …
Epithelial CST1 Promotes Airway Eosinophilic Inflammation in Asthma via the AKT Signaling Pathway.
Du L, Xu C, Tang K, Shi J, Tang L, Lisha X, Lei C, Liu H, Liang Y, Guo Y. Du L, et al. Allergy Asthma Immunol Res. 2023 May;15(3):374-394. doi: 10.4168/aair.2023.15.3.374. Epub 2023 Mar 8. Allergy Asthma Immunol Res. 2023. PMID: 37075800 Free PMC article.
The possible function of CST1 was explored in ovalbumin (OVA)-induced eosinophilic asthma. ...CST1 aggravated airway eosinophilic inflammation in the OVA-induced asthma model. ...
The possible function of CST1 was explored in ovalbumin (OVA)-induced eosinophilic asthma. ...CST1 aggravated airway eosinophi …
CST1 Promoted Gastric Cancer Migration and Invasion Through Activating Wnt Pathway.
Chen S, Liu Y, Zhang K, Chen L. Chen S, et al. Cancer Manag Res. 2021 Feb 24;13:1901-1907. doi: 10.2147/CMAR.S277770. eCollection 2021. Cancer Manag Res. 2021. PMID: 33658852 Free PMC article.
RESULTS: CST1 had high expression levels in gastric cancer tissues and cells, patients who had high CST1 expression had poor outcome. Overexpression of CST1 increased gastric cancer migration and invasion, while knockdown of CST1 suppressed gastric can …
RESULTS: CST1 had high expression levels in gastric cancer tissues and cells, patients who had high CST1 expression had poor o …
Epithelium-derived cystatin SN inhibits house dust mite protease activity in allergic asthma.
Yao L, Yuan X, Fu H, Guo Q, Wu Y, Xuan S, Kermani NZ, Adcock IM, Zeng X, Liu Y, Xie M, Yao X. Yao L, et al. Allergy. 2023 Jun;78(6):1507-1523. doi: 10.1111/all.15739. Epub 2023 Apr 20. Allergy. 2023. PMID: 37026502
The cysteine protease activity of house dust mite (HDM) disrupts the epithelial barrier function. The expression of cystatin SN (CST1) is elevated in asthma epithelium. CST1 inhibits the cysteine protease activity. ...CST1 protein may serve as a potential bio …
The cysteine protease activity of house dust mite (HDM) disrupts the epithelial barrier function. The expression of cystatin SN (CST1 …
Cystatin SN (CST1) as a Novel Salivary Biomarker of Periodontitis.
Romano F, Franco F, Corana M, Abbadessa G, Di Scipio F, Pergolizzi B, Castrignano C, Aimetti M, Berta GN. Romano F, et al. Int J Mol Sci. 2023 Sep 8;24(18):13834. doi: 10.3390/ijms241813834. Int J Mol Sci. 2023. PMID: 37762137 Free PMC article.

Protein spots of interest were analysed by MALDI-TOF-MS, allowing the identification of cystatin SN (CST1) isoform, as confirmed by Western blot. CST1 was markedly expressed in the H group, while it was absent in most P samples (p < 0.001). ...Therefore, salivary

…
Protein spots of interest were analysed by MALDI-TOF-MS, allowing the identification of cystatin SN (CST1) isoform, as confirmed by W …
CST1 promotes the proliferation and migration of PDGF-BB-treated airway smooth muscle cells via the PI3K/AKT signaling pathway.
Liu HB, Bai J, Wang WX. Liu HB, et al. Kaohsiung J Med Sci. 2023 Feb;39(2):145-153. doi: 10.1002/kjm2.12619. Epub 2022 Nov 10. Kaohsiung J Med Sci. 2023. PMID: 36354198 Free article.
However, the role of CST1 and related molecular mechanisms in the development of asthma remains to be explored. This study aims to investigate the role of CST1 in asthma progression and present related molecular mechanisms. ...
However, the role of CST1 and related molecular mechanisms in the development of asthma remains to be explored. This study aims to in …
Combination of serum CST1 and HE4 for early diagnosis of endometrial cancer.
Zhong W, Liu Y, Zhang L, Zhuang W, Chen J, Huang Z, Zheng Y, Huang Y. Zhong W, et al. PeerJ. 2023 Dec 5;11:e16424. doi: 10.7717/peerj.16424. eCollection 2023. PeerJ. 2023. PMID: 38077439 Free PMC article.
Combined detection of serum CST1 and HE4 exhibited an AUC of 0.788 with 49.3% sensitivity at 92.5% specificity. The combination of serum CST1 and HE4 showed promise in diagnosis. CONCLUSION: CST1 is a prospective serological biomarker for early EC diagnosis, …
Combined detection of serum CST1 and HE4 exhibited an AUC of 0.788 with 49.3% sensitivity at 92.5% specificity. The combination of se …
Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment.
Dinh HQ, Pan F, Wang G, Huang QF, Olingy CE, Wu ZY, Wang SH, Xu X, Xu XE, He JZ, Yang Q, Orsulic S, Haro M, Li LY, Huang GW, Breunig JJ, Koeffler HP, Hedrick CC, Xu LY, Lin DC, Li EM. Dinh HQ, et al. Nat Commun. 2021 Dec 17;12(1):7335. doi: 10.1038/s41467-021-27599-5. Nat Commun. 2021. PMID: 34921160 Free PMC article.
We uncover heterogeneity in most cell types of the ESCC stroma, particularly in the fibroblast and immune cell compartments. We identify a tumor-specific subset of CST1(+) myofibroblasts with prognostic values and potential biological significance. CST1(+) myofibrob …
We uncover heterogeneity in most cell types of the ESCC stroma, particularly in the fibroblast and immune cell compartments. We identify a t …
MicroRNA-375 inhibits laryngeal squamous cell carcinoma progression via targeting CST1.
Dai F, Xie Z, Yang Q, Zhong Z, Zhong C, Qiu Y. Dai F, et al. Braz J Otorhinolaryngol. 2022 Nov-Dec;88 Suppl 4(Suppl 4):S108-S116. doi: 10.1016/j.bjorl.2022.06.005. Epub 2022 Jul 6. Braz J Otorhinolaryngol. 2022. PMID: 35953439 Free PMC article.
METHODS: LSCC cells (LSC-1 and TU177) were transfected with miR-375-mimic, miR-375-inhibitor or miR-375-mimic+oe-CST1. The expression of miR-375, CST1, MMP-2, and MMP-9 was measured. ...Jefferson database and dual luciferase reporter gene assay confirmed that miR-37 …
METHODS: LSCC cells (LSC-1 and TU177) were transfected with miR-375-mimic, miR-375-inhibitor or miR-375-mimic+oe-CST1. The expression …
183 results