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CRELD2, endoplasmic reticulum stress, and human diseases.
Tang Q, Liu Q, Li Y, Mo L, He J. Tang Q, et al. Front Endocrinol (Lausanne). 2023 Mar 2;14:1117414. doi: 10.3389/fendo.2023.1117414. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36936176 Free PMC article. Review.
The expression and secretion of CRELD2 are dramatically induced by ER stress. CRELD2 is ubiquitously expressed in multiple tissues at different levels, suggesting its crucial and diverse roles in different tissues. ...Herein, we first summarize ER stress and then cr …
The expression and secretion of CRELD2 are dramatically induced by ER stress. CRELD2 is ubiquitously expressed in multiple tis …
Creld2 function during unfolded protein response is essential for liver metabolism homeostasis.
Kern P, Balzer NR, Blank N, Cygon C, Wunderling K, Bender F, Frolov A, Sowa JP, Bonaguro L, Ulas T, Homrich M, Kiermaier E, Thiele C, Schultze JL, Canbay A, Bauer R, Mass E. Kern P, et al. FASEB J. 2021 Oct;35(10):e21939. doi: 10.1096/fj.202002713RR. FASEB J. 2021. PMID: 34549824
To this end, we generated Creld2-deficient mice and induced UPR by injection of tunicamycin. ...Thereby, Creld2 promotes tolerance to ER stress and recovery from acute stress. ...
To this end, we generated Creld2-deficient mice and induced UPR by injection of tunicamycin. ...Thereby, Creld2 promotes toler …
CRELD2 is a novel modulator of calcium release and calcineurin-NFAT signalling during osteoclast differentiation.
Duxfield A, Munkley J, Briggs MD, Dennis EP. Duxfield A, et al. Sci Rep. 2022 Aug 16;12(1):13884. doi: 10.1038/s41598-022-17347-0. Sci Rep. 2022. PMID: 35974042 Free PMC article.
Cysteine rich with epidermal growth factor (EGF)-like domains 2 (CRELD2) is an endoplasmic reticulum (ER) resident chaperone protein with calcium binding properties. ...Despite CRELD2 having an established role in skeletal development and bone formation, its role in …
Cysteine rich with epidermal growth factor (EGF)-like domains 2 (CRELD2) is an endoplasmic reticulum (ER) resident chaperone protein …
CRELD2 Is a Novel LRP1 Chaperone That Regulates Noncanonical WNT Signaling in Skeletal Development.
Dennis EP, Edwards SM, Jackson RM, Hartley CL, Tsompani D, Capulli M, Teti A, Boot-Handford RP, Young DA, Piróg KA, Briggs MD. Dennis EP, et al. J Bone Miner Res. 2020 Aug;35(8):1452-1469. doi: 10.1002/jbmr.4010. Epub 2020 Apr 9. J Bone Miner Res. 2020. PMID: 32181934 Free article.
We show for the first time that cartilage-specific deletion of Creld2 results in disrupted endochondral ossification and short limbed dwarfism, whereas deletion of Creld2 in bone results in osteopenia, with a low bone density and altered trabecular architecture. Our …
We show for the first time that cartilage-specific deletion of Creld2 results in disrupted endochondral ossification and short limbed …
GREB1L, CRELD2 and ITGA10 expression in the human developmental and postnatal kidneys: an immunohistochemical study.
Lasić V, Kosović I, Jurić M, Racetin A, Čurčić J, Šolić I, Lozić M, Filipović N, Šoljić V, Martinović V, Saraga-Babić M, Vukojević K. Lasić V, et al. Acta Histochem. 2021 Feb;123(2):151679. doi: 10.1016/j.acthis.2021.151679. Epub 2021 Jan 15. Acta Histochem. 2021. PMID: 33460985

In DCT there were statistically significant differences in CRELD2 positive cells in 13 w, 15 w, 16 w, 21 w, 38 w and 7.5y regarding 1.5y (Kruskal-Wallis test, p < 0.01). ITGA10 and CRELD2 co-localised in the postnatal period in DCT. CONCLUSION: High kidney expres

In DCT there were statistically significant differences in CRELD2 positive cells in 13 w, 15 w, 16 w, 21 w, 38 w and 7.5y regarding 1 …
CRELD2 is a novel endoplasmic reticulum stress-inducible gene.
Oh-hashi K, Koga H, Ikeda S, Shimada K, Hirata Y, Kiuchi K. Oh-hashi K, et al. Biochem Biophys Res Commun. 2009 Sep 25;387(3):504-10. doi: 10.1016/j.bbrc.2009.07.047. Epub 2009 Jul 15. Biochem Biophys Res Commun. 2009. PMID: 19615339
CRELD2 mRNA is also shown to be immediately induced by treatment with the ER stress-inducing reagents tunicamycin and brefeldin A. ...Our study suggests that CRELD2 could be a novel mediator in regulating the onset and progression of various ER stress-associated dis
CRELD2 mRNA is also shown to be immediately induced by treatment with the ER stress-inducing reagents tunicamycin and brefeldin A. ..
CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region.
Maslen CL, Babcock D, Redig JK, Kapeli K, Akkari YM, Olson SB. Maslen CL, et al. Gene. 2006 Nov 1;382:111-20. doi: 10.1016/j.gene.2006.06.016. Epub 2006 Jul 7. Gene. 2006. PMID: 16919896
Like CRELD1, CRELD2 is ubiquitously expressed during development and by mature tissues. ...Confirmed splice variants encode 5 different CRELD2 isoforms that differ significantly in composition indicating that CRELD2 function is varied and as yet poorly unders …
Like CRELD1, CRELD2 is ubiquitously expressed during development and by mature tissues. ...Confirmed splice variants encode 5 differe …
ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism.
Boyle ST, Poltavets V, Kular J, Pyne NT, Sandow JJ, Lewis AC, Murphy KJ, Kolesnikoff N, Moretti PAB, Tea MN, Tergaonkar V, Timpson P, Pitson SM, Webb AI, Whitfield RJ, Lopez AF, Kochetkova M, Samuel MS. Boyle ST, et al. Nat Cell Biol. 2020 Jul;22(7):882-895. doi: 10.1038/s41556-020-0523-y. Epub 2020 May 25. Nat Cell Biol. 2020. PMID: 32451439
An analysis of tumours from patients and mice reveals that cysteine-rich with EGF-like domains 2 (CRELD2) is the paracrine factor that underlies PERK-mediated CAF education downstream of ROCK. We find that CRELD2 is regulated by PERK-regulated ATF4, and depleting …
An analysis of tumours from patients and mice reveals that cysteine-rich with EGF-like domains 2 (CRELD2) is the paracrine factor tha …
Characterization of the Role of MANF in Regulating the Secretion of CRELD2.
Oh-hashi K, Norisada J, Hirata Y, Kiuchi K. Oh-hashi K, et al. Biol Pharm Bull. 2015;38(5):722-31. doi: 10.1248/bpb.b14-00825. Biol Pharm Bull. 2015. PMID: 25947918 Free article.
In the present study, we found that the co-transfection of CRELD2 and MANF remarkably enhanced the secretion of CRELD2 without affecting the expression level of GRP78. To identify the structural features of CRELD2 and MANF involved in this process, we generat …
In the present study, we found that the co-transfection of CRELD2 and MANF remarkably enhanced the secretion of CRELD2 without …
Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease.
Kim Y, Park SJ, Manson SR, Molina CA, Kidd K, Thiessen-Philbrook H, Perry RJ, Liapis H, Kmoch S, Parikh CR, Bleyer AJ, Chen YM. Kim Y, et al. JCI Insight. 2017 Dec 7;2(23):e92896. doi: 10.1172/jci.insight.92896. JCI Insight. 2017. PMID: 29212948 Free PMC article.
Most importantly, urinary CRELD2 elevation occurs in patients with autosomal dominant tubulointerstitial kidney disease caused by UMOD mutations, a prototypical tubular ER stress disease. In addition, in pediatric patients undergoing cardiac surgery, detectable urine level …
Most importantly, urinary CRELD2 elevation occurs in patients with autosomal dominant tubulointerstitial kidney disease caused by UMO …
52 results