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Year Number of Results
1989 2
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1991 4
1992 1
1994 3
1995 4
1997 4
2000 2
2001 3
2004 1
2005 3
2006 1
2007 1
2008 1
2009 3
2010 4
2011 1
2012 3
2013 1
2014 1
2015 4
2016 4
2017 4
2018 3
2019 5
2020 2
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2022 10
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2024 2

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83 results

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Page 1
Endoplasmic stress-inducing variants in CPB1 and CPA1 and risk of pancreatic cancer: A case-control study and meta-analysis.
Kawamoto M, Kohi S, Abe T, Dbouk M, Macgregor-Das A, Koi C, Song KB, Borges M, Sugimine R, Laheru D, Hruban RH, Roberts N, Klein AP, Goggins M. Kawamoto M, et al. Int J Cancer. 2022 Apr 1;150(7):1123-1133. doi: 10.1002/ijc.33883. Epub 2021 Dec 6. Int J Cancer. 2022. PMID: 34817877 Free PMC article.
Of the 1385 patients with PDAC, 0.65% were found to harbor an ER stress-inducing variant in CPA1 or CPB1, compared to 0.17% of the 64 026 controls (odds ratio [OR]: 3.80 [1.92-7.51], P = .0001). ...Meta-analysis demonstrated strong associations for pancreatic cancer and ER …
Of the 1385 patients with PDAC, 0.65% were found to harbor an ER stress-inducing variant in CPA1 or CPB1, compared to 0.17% of the 64 …
Prevalence of Germline Sequence Variations Among Patients With Pancreatic Cancer in China.
Yin L, Wei J, Lu Z, Huang S, Gao H, Chen J, Guo F, Tu M, Xiao B, Xi C, Zhang K, Li Q, Wu J, Gao W, Jiang K, Yu J, Miao Y. Yin L, et al. JAMA Netw Open. 2022 Feb 1;5(2):e2148721. doi: 10.1001/jamanetworkopen.2021.48721. JAMA Netw Open. 2022. PMID: 35171259 Free PMC article.
Variations in the pancreatic secretory enzyme genes CPA1 and CPB1 were not detected in the Nanjing cohort. CONCLUSIONS AND RELEVANCE: In this genetic association study, sporadic pancreatic cancer was associated with pathogenic germline variations in a cohort from China. .. …
Variations in the pancreatic secretory enzyme genes CPA1 and CPB1 were not detected in the Nanjing cohort. CONCLUSIONS AND RELEVANCE: …
Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer.
Tamura K, Yu J, Hata T, Suenaga M, Shindo K, Abe T, MacGregor-Das A, Borges M, Wolfgang CL, Weiss MJ, He J, Canto MI, Petersen GM, Gallinger S, Syngal S, Brand RE, Rustgi A, Olson SH, Stoffel E, Cote ML, Zogopoulos G, Potash JB, Goes FS, McCombie RW, Zandi PP, Pirooznia M, Kramer M, Parla J, Eshleman JR, Roberts NJ, Hruban RH, Klein AP, Goggins M. Tamura K, et al. Proc Natl Acad Sci U S A. 2018 May 1;115(18):4767-4772. doi: 10.1073/pnas.1720588115. Epub 2018 Apr 18. Proc Natl Acad Sci U S A. 2018. PMID: 29669919 Free PMC article. Clinical Trial.
Variants in CPB1, CPA1 (encoding carboxypeptidase B1 and A1), and CTRC were evaluated in a second set of cases with familial pancreatic cancer and controls. ...Our study indicates ER stress-inducing variants in CPB1 and CPA1 are associated with pancreatic cancer sus …
Variants in CPB1, CPA1 (encoding carboxypeptidase B1 and A1), and CTRC were evaluated in a second set of cases with familial pancreat …
Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.
Nakano E, Geisz A, Masamune A, Niihori T, Hamada S, Kume K, Kakuta Y, Aoki Y, Matsubara Y, Ebert K, Ludwig M, Braun M, Groneberg DA, Shimosegawa T, Sahin-Tóth M, Witt H. Nakano E, et al. Am J Physiol Gastrointest Liver Physiol. 2015 Oct 15;309(8):G688-94. doi: 10.1152/ajpgi.00241.2015. Epub 2015 Aug 27. Am J Physiol Gastrointest Liver Physiol. 2015. PMID: 26316592 Free PMC article.
Besides CPA1, there are two other human pancreatic carboxypeptidases (CPA2 and CPB1). Here we examined whether CPA2 and CPB1 alterations are associated with CP in Japan and Germany. ...In conclusion, CPA2 and CPB1 variants are not associated with CP....
Besides CPA1, there are two other human pancreatic carboxypeptidases (CPA2 and CPB1). Here we examined whether CPA2 and CPB1 a …
CPB1 of Aedes aegypti interacts with DENV2 E protein and regulates intracellular viral accumulation and release from midgut cells.
Tham HW, Balasubramaniam VR, Tejo BA, Ahmad H, Hassan SS. Tham HW, et al. Viruses. 2014 Dec 16;6(12):5028-46. doi: 10.3390/v6125028. Viruses. 2014. PMID: 25521592 Free PMC article.
Our double immunofluorescent assay showed that CPB1-E interaction occurred in the endoplasmic reticulum (ER) of the Ae. aegypti primary midgut cells. Overexpression of CPB1 in mosquito cells resulted in intracellular DENV2 genomic RNA or virus particle accumulation, …
Our double immunofluorescent assay showed that CPB1-E interaction occurred in the endoplasmic reticulum (ER) of the Ae. aegypti prima …
Phosphorylation of carboxypeptidase B1 protein regulates β-cell proliferation.
Yu SL, Han S, Kim HR, Park JW, Jin DI, Kang J. Yu SL, et al. Int J Mol Med. 2017 Nov;40(5):1397-1404. doi: 10.3892/ijmm.2017.3141. Epub 2017 Sep 19. Int J Mol Med. 2017. PMID: 28949379 Free PMC article.
The motif of CPB1 PTMs was identified by mass spectrophotometry, and the downregulation of CPB1 phosphorylation in pancreatectomy was confirmed. The dephosphorylation of CPB1 induced beta-cell proliferation. We thus surmise that the altered PTM of CPB1 …
The motif of CPB1 PTMs was identified by mass spectrophotometry, and the downregulation of CPB1 phosphorylation in pancreatect …
Is Carboxypeptidase B1 a Prognostic Marker for Ductal Carcinoma In Situ?
Kothari C, Clemenceau A, Ouellette G, Ennour-Idrissi K, Michaud A, Diorio C, Durocher F. Kothari C, et al. Cancers (Basel). 2021 Apr 6;13(7):1726. doi: 10.3390/cancers13071726. Cancers (Basel). 2021. PMID: 33917306 Free PMC article.
High CPB1 expression correlated with better survival outcome, and mRNA level was highest in DCIS than DCIS adjacent to IDC and IDC. ...The expression of CPB1 could predict 90.1% of DCIS in a cohort consisting of DCIS and IDC. ...
High CPB1 expression correlated with better survival outcome, and mRNA level was highest in DCIS than DCIS adjacent to IDC and IDC. . …
DNA-binding protein involved in the regulation of chitinase production in Streptomyces lividans.
Fujii T, Miyashita K, Ohtomo R, Saito A. Fujii T, et al. Biosci Biotechnol Biochem. 2005 Apr;69(4):790-9. doi: 10.1271/bbb.69.790. Biosci Biotechnol Biochem. 2005. PMID: 15849419 Free article.
Determining the amino-terminal amino acid sequence of the purified protein led to cloning of a gene (cpb1) encoding the chitinase promoter-binding protein, Cpb1. The deduced amino acid sequence of Cpb1 showed significant similarity to the sequences of a group …
Determining the amino-terminal amino acid sequence of the purified protein led to cloning of a gene (cpb1) encoding the chitinase pro …
83 results