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Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit zeta 2 renders tumor cells dependent on its paralogous gene COPZ1.
Shtutman M, Baig M, Levina E, Hurteau G, Lim CU, Broude E, Nikiforov M, Harkins TT, Carmack CS, Ding Y, Wieland F, Buttyan R, Roninson IB. Shtutman M, et al. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12449-54. doi: 10.1073/pnas.1103842108. Epub 2011 Jul 11. Proc Natl Acad Sci U S A. 2011. PMID: 21746916 Free PMC article.
Reexpression of COPZ2 protected tumor cells from killing by COPZ1 knockdown, indicating that tumor cell dependence on COPZ1 is the result of COPZ2 silencing. COPZ2 displays no tumor-suppressive activities, but it harbors microRNA 152, which is silenced in tum …
Reexpression of COPZ2 protected tumor cells from killing by COPZ1 knockdown, indicating that tumor cell dependence on COPZ1 is the re …
ArfGAP3 regulates vesicle transport and glucose uptake in myoblasts.
Li S, Wang Z, Chen M, Xiao Y, Min J, Hu M, Tang J, Hong L. Li S, et al. Cell Signal. 2023 Mar;103:110551. doi: 10.1016/j.cellsig.2022.110551. Epub 2022 Dec 5. Cell Signal. 2023. PMID: 36476390
In this study, datasets related to skeletal muscle injury and myoblast differentiation GSE469, GSE5413, GSE45577 and GSE108040 were retrieved through the GEO database and the expression of heptameric coat protein complex I (COPI) and Golgi vesicle transport-related genes in vario …
In this study, datasets related to skeletal muscle injury and myoblast differentiation GSE469, GSE5413, GSE45577 and GSE108040 were retrieve …
The interplay of the metallosensor CueR with two distinct CopZ chaperones defines copper homeostasis in Pseudomonas aeruginosa.
Novoa-Aponte L, Ramírez D, Argüello JM. Novoa-Aponte L, et al. J Biol Chem. 2019 Mar 29;294(13):4934-4945. doi: 10.1074/jbc.RA118.006316. Epub 2019 Feb 4. J Biol Chem. 2019. PMID: 30718281 Free PMC article.

Although this observation was consistent with the relative Cu(+) affinities of the three proteins (CopZ1 < CueR < CopZ2), in vitro and in silico analyses also indicated a stronger interaction between CopZ1 and CueR that was independent of Cu(+) In contrast, CopZ2

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Although this observation was consistent with the relative Cu(+) affinities of the three proteins (CopZ1 < CueR < CopZ2), in vi

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Copper homeostasis-related genes in three separate transcriptional units regulated by CsoR in Corynebacterium glutamicum.
Teramoto H, Yukawa H, Inui M. Teramoto H, et al. Appl Microbiol Biotechnol. 2015 Apr;99(8):3505-17. doi: 10.1007/s00253-015-6373-z. Epub 2015 Jan 16. Appl Microbiol Biotechnol. 2015. PMID: 25592736
The monocistronic copZ2 transcript was upregulated by excess copper in a CsoR-dependent manner. ...A redundant role of copZ1 and copZ2 in copper resistance was also indicated by double deletion of these genes. ...
The monocistronic copZ2 transcript was upregulated by excess copper in a CsoR-dependent manner. ...A redundant role of copZ1 and c …
A workflow to study mechanistic indicators for driver gene prediction with Moonlight.
Nourbakhsh M, Saksager A, Tom N, Chen XS, Colaprico A, Olsen C, Tiberti M, Papaleo E. Nourbakhsh M, et al. Brief Bioinform. 2023 Sep 20;24(5):bbad274. doi: 10.1093/bib/bbad274. Brief Bioinform. 2023. PMID: 37551622
For example, in basal-like breast cancer, we found four oncogenes (COPZ2, SF3B4, KRTCAP2 and POLR2J) and nine tumor suppressor genes (KIR2DL4, KIF26B, ARL15, ARHGAP25, EMCN, GMFG, TPK1, NR5A2 and TEK) containing a driver mutation in their promoter region, possibly explaini …
For example, in basal-like breast cancer, we found four oncogenes (COPZ2, SF3B4, KRTCAP2 and POLR2J) and nine tumor suppressor genes …
Genetic and Expression Analysis of COPI Genes and Alzheimer's Disease Susceptibility.
Yang Y, Wang X, Ju W, Sun L, Zhang H. Yang Y, et al. Front Genet. 2019 Sep 19;10:866. doi: 10.3389/fgene.2019.00866. eCollection 2019. Front Genet. 2019. PMID: 31608112 Free PMC article.
We further conducted an expression quantitative trait loci (eQTLs) analysis and found that rs9898218 G allele was associated with increased COPZ2 expression in cerebellar cortex with P = 0.0184. Importantly, the eQTLs analysis in whole blood further indicated that 11 of th …
We further conducted an expression quantitative trait loci (eQTLs) analysis and found that rs9898218 G allele was associated with increased …
Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression.
Greliche N, Zeller T, Wild PS, Rotival M, Schillert A, Ziegler A; Cardiogenics Consortium; Deloukas P, Erdmann J, Hengstenberg C, Ouwehand WH, Samani NJ, Schunkert H, Munzel T, Lackner KJ, Cambien F, Goodall AH, Tiret L, Blankenberg S, Trégouët DA. Greliche N, et al. PLoS One. 2012;7(9):e45863. doi: 10.1371/journal.pone.0045863. Epub 2012 Sep 21. PLoS One. 2012. PMID: 23029284 Free PMC article.
In both studies, the hsa-mir-1279 rs1463335 was found to modulate in cis the expression of LYZ and in trans the expression of CNTN6, CTRC, COPZ2, KRT9, LRRFIP1, NOD1, PCDHA6, ST5 and TRAF3IP2 genes, supporting the role of hsa-mir-1279 as a regulator of several genes in mon …
In both studies, the hsa-mir-1279 rs1463335 was found to modulate in cis the expression of LYZ and in trans the expression of CNTN6, CTRC, …
An integrative analysis of the tumor suppressors and oncogenes from sexual dimorphism and gene expression alteration features in thyroid cancer.
Huang Y, Wang Y, Liu S, Xu Z, Chen WX. Huang Y, et al. Cancer Biomark. 2023;38(1):1-16. doi: 10.3233/CBM-230029. Cancer Biomark. 2023. PMID: 37355885
RESULTS: Female sex was identified as a risk factor for thyroid cancer. The expression of PAPSS2, PDLIM3, COPZ2, ALDH1B1, ANTXR1, GUF1, and SENP6 negatively correlated with thyroid cancer prognosis. CONCLUSION: Female sex was a risk factor for thyroid cancer. In addition, …
RESULTS: Female sex was identified as a risk factor for thyroid cancer. The expression of PAPSS2, PDLIM3, COPZ2, ALDH1B1, ANTXR1, GUF …
Identification and validation of SLCO4C1 as a biological marker in hepatocellular carcinoma based on anoikis classification features.
Wang T, Guo K, Yang S, Zhang D, Cui H, Yin J, Yuan S, Wang Y, Qi Y, Wu W. Wang T, et al. Aging (Albany NY). 2024 Jan 15;16(2):1440-1462. doi: 10.18632/aging.205438. Epub 2024 Jan 15. Aging (Albany NY). 2024. PMID: 38226966 Free PMC article.
RESULTS: HCC was divided into 2 anoikis subtypes, and the subtypeB had a better prognosis. An anoikis prognostic model based on 12 (COPZ2, ACTG2, IFI27, SPP1, EPO, SLCO4C1, RAB26, STC2, RAC3, NQO1, MYCN, HSPA1B) risk genes is important for survival and prognosis. ...
RESULTS: HCC was divided into 2 anoikis subtypes, and the subtypeB had a better prognosis. An anoikis prognostic model based on 12 (COPZ2 …
16 results