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An integrative pan-cancer analysis of molecular characteristics and oncogenic role of mitochondrial creatine kinase 1A (CKMT1A) in human tumors.
Yang M, Liu S, Xiong Y, Zhao J, Deng W. Yang M, et al. Sci Rep. 2022 Jun 15;12(1):10025. doi: 10.1038/s41598-022-14346-z. Sci Rep. 2022. PMID: 35705641 Free PMC article.
In recent years, several studies have suggested that mitochondrial creatine kinase 1A (CKMT1A) plays a key role in various cancer types. However, there is still a lack of systematic understanding of the contribution of CKMT1A in different types of cancer …
In recent years, several studies have suggested that mitochondrial creatine kinase 1A (CKMT1A) plays a key role in various cancer …
CKMT1A is a novel potential prognostic biomarker in patients with endometrial cancer.
Wang Y, Zhao S, Qin Q, Gao X, Zhang X, Zhang M, Jiang Y, Ji X, Zhu H, Zhao X, Li H. Wang Y, et al. PLoS One. 2022 Jan 25;17(1):e0262000. doi: 10.1371/journal.pone.0262000. eCollection 2022. PLoS One. 2022. PMID: 35077462 Free PMC article.
Through survival analyses, we found that CKMT1A may be a poor prognostic factor in the overall survival of endometrial cancer patients. GO and Pathways revealed that CKMT1A is closely associated with the metabolic process. More importantly, Human Prote …
Through survival analyses, we found that CKMT1A may be a poor prognostic factor in the overall survival of endometrial cancer …
LncRNA n335586/miR-924/CKMT1A axis contributes to cell migration and invasion in hepatocellular carcinoma cells.
Fan H, Lv P, Mu T, Zhao X, Liu Y, Feng Y, Lv J, Liu M, Tang H. Fan H, et al. Cancer Lett. 2018 Aug 10;429:89-99. doi: 10.1016/j.canlet.2018.05.010. Epub 2018 May 16. Cancer Lett. 2018. PMID: 29753758
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide and chronic hepatitis B virus (HBV) infection is a major risk factor for HCC. ...Further mechanistic studies showed lncRNA n335586 promoted HCC cells migration and invasion through facilitating the …
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide and chronic hepatitis B virus (HBV) infection is a major …
Mitochondrial creatine kinase 1 in non-small cell lung cancer progression and hypoxia adaptation.
Li M, Liu H, Li J, Guo S, Lv Y. Li M, et al. Respir Res. 2021 Jul 1;22(1):190. doi: 10.1186/s12931-021-01765-1. Respir Res. 2021. PMID: 34210337 Free PMC article.
BACKGROUND: Hypoxia is a prominent feature of solid cancer. This research aims to expose the role of mitochondrial creatine kinase 1 (CKMT1) in non-small cell lung cancer (NSCLC) progression and hypoxia adaptation. ...
BACKGROUND: Hypoxia is a prominent feature of solid cancer. This research aims to expose the role of mitochondrial creatine kinase 1 …
Deficiency of polypeptide N-acetylgalactosamine transferase 9 contributes to a risk for Parkinson's disease via mitochondrial dysfunctions.
Peng Y, Wang C, Ma W, Chen Q, Xu G, Kong Y, Ma L, Ding W, Zhang W. Peng Y, et al. Int J Biol Macromol. 2024 Apr;263(Pt 2):130347. doi: 10.1016/j.ijbiomac.2024.130347. Epub 2024 Feb 23. Int J Biol Macromol. 2024. PMID: 38401583
MS identification revealed 14 glycoproteins. 5 glycoproteins, including ACO(2), ATP5B, CKB, CKMT1A, ALDOC, were associated with energy metabolism. GALNT9 silencing resulted in mitochondrial dysfunctions via increasing ROS accumulation, mitochondrial membrane depolar …
MS identification revealed 14 glycoproteins. 5 glycoproteins, including ACO(2), ATP5B, CKB, CKMT1A, ALDOC, were associated with energ …
Effects of CKMT1 on radiosensitivity of nasopharyngeal carcinoma cells.
Lan R, Huang F, Zhong G, Chen R, Wang Z, Chen J, Fu L, Hong J, Zhang L. Lan R, et al. Int J Radiat Biol. 2019 May;95(5):597-606. doi: 10.1080/09553002.2019.1554919. Epub 2019 Jan 4. Int J Radiat Biol. 2019. PMID: 30507333
Ubiquitous mitochondrial creatine kinase (CKMT1) is always associated with malignancy in a variety of cancers. However, its significance in NPC progression and radiosensitivity remains unclear. ...
Ubiquitous mitochondrial creatine kinase (CKMT1) is always associated with malignancy in a variety of cancers. However, its significa …
Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway.
Kurmi K, Hitosugi S, Yu J, Boakye-Agyeman F, Wiese EK, Larson TR, Dai Q, Machida YJ, Lou Z, Wang L, Boughey JC, Kaufmann SH, Goetz MP, Karnitz LM, Hitosugi T. Kurmi K, et al. Cell Metab. 2018 Dec 4;28(6):833-847.e8. doi: 10.1016/j.cmet.2018.08.008. Epub 2018 Aug 30. Cell Metab. 2018. PMID: 30174304 Free PMC article.
How mitochondrial metabolism is altered by oncogenic tyrosine kinases to promote tumor growth is incompletely understood. ...These findings suggest that activation of the phosphocreatine energy shuttle by MtCK1 Y153 phosphorylation creates a druggable metabolic vuln …
How mitochondrial metabolism is altered by oncogenic tyrosine kinases to promote tumor growth is incompletely understood. ...These fi …
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia.
Fenouille N, Bassil CF, Ben-Sahra I, Benajiba L, Alexe G, Ramos A, Pikman Y, Conway AS, Burgess MR, Li Q, Luciano F, Auberger P, Galinsky I, DeAngelo DJ, Stone RM, Zhang Y, Perkins AS, Shannon K, Hemann MT, Puissant A, Stegmaier K. Fenouille N, et al. Nat Med. 2017 Mar;23(3):301-313. doi: 10.1038/nm.4283. Epub 2017 Feb 13. Nat Med. 2017. PMID: 28191887 Free PMC article.
Here, through transcriptomic and metabolomic profiling of hematopoietic cells, we reveal that EVI1 overexpression alters cellular metabolism. A screen using pooled short hairpin RNAs (shRNAs) identified the ATP-buffering, mitochondrial creatine kinase CKMT1 as necessary fo …
Here, through transcriptomic and metabolomic profiling of hematopoietic cells, we reveal that EVI1 overexpression alters cellular metabol …