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N-Glycosylation Regulates Chitinase 3-like-1 and IL-13 Ligand Binding to IL-13 Receptor alpha2.
He CH, Lee CG, Ma B, Kamle S, Choi AMK, Elias JA. He CH, et al. Am J Respir Cell Mol Biol. 2020 Sep;63(3):386-395. doi: 10.1165/rcmb.2019-0446OC. Am J Respir Cell Mol Biol. 2020. PMID: 32402213 Free PMC article.
Chitinase 3-like-1 (Chi3l1) and IL-13 are both ligands of IL-13 receptor alpha2 (IL-13Ralpha2). ...Here, we demonstrate that IL-13Ralpha2 N-glycosylation is a critical determinant of which ligand binds. Structure-function evaluations demonstrated that Chi3 …
Chitinase 3-like-1 (Chi3l1) and IL-13 are both ligands of IL-13 receptor alpha2 (IL-13Ralpha2). ...Here, we demonstrate that I …
Knockdown of Chitinase 3-Like-1 Inhibits Cell Proliferation, Promotes Apoptosis, and Enhances Effect of Anti-Programmed Death Ligand 1 (PD-L1) in Diffuse Large B Cell Lymphoma Cells.
Yang X, Fang D, Li M, Chen J, Cheng Y, Luo J. Yang X, et al. Med Sci Monit. 2021 Mar 25;27:e929431. doi: 10.12659/MSM.929431. Med Sci Monit. 2021. PMID: 33764958 Free PMC article.
Based on this, we investigated how CHI3L1 acts on the proliferation and apoptosis of DLBCL and whether there is a synergy of CHI3L1 in combination with anti-PD-L1 antibodies in vivo. ...RESULTS CHI3L1 was significantly expressed in SU-DHL-4 cells. CHI3L1 …
Based on this, we investigated how CHI3L1 acts on the proliferation and apoptosis of DLBCL and whether there is a synergy of CHI3L …
Steroid Hormone Receptor and Infiltrating Immune Cell Status Reveals Therapeutic Vulnerabilities of ESR1-Mutant Breast Cancer.
Williams MM, Spoelstra NS, Arnesen S, O'Neill KI, Christenson JL, Reese J, Torkko KC, Goodspeed A, Rosas E, Hanamura T, Sams SB, Li Z, Oesterreich S, Riggins RB, Jacobsen BM, Elias A, Gertz J, Richer JK. Williams MM, et al. Cancer Res. 2021 Feb 1;81(3):732-746. doi: 10.1158/0008-5472.CAN-20-1200. Epub 2020 Nov 12. Cancer Res. 2021. PMID: 33184106 Free PMC article.
Mutations in ESR1 that confer constitutive estrogen receptor alpha (ER) activity in the absence of ligand are acquired by 40% of metastatic breast cancers (MBC) resistant to adjuvant aromatase inhibitor (AI) therapy. To identify targetable vulnerabilities in MBC, we …
Mutations in ESR1 that confer constitutive estrogen receptor alpha (ER) activity in the absence of ligand are acquired by 40% …
Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties.
Schimpl M, Rush CL, Betou M, Eggleston IM, Recklies AD, van Aalten DM. Schimpl M, et al. Biochem J. 2012 Aug 15;446(1):149-57. doi: 10.1042/BJ20120377. Biochem J. 2012. PMID: 22742450 Free PMC article.
Strikingly, the chitinase activity of YKL-39 was recovered by reverting two non-conservative substitutions in the active site to those found in the active enzymes, suggesting that YKL-39 is a pseudo-chitinase with retention of chitinase-like ligand-binding properties....
Strikingly, the chitinase activity of YKL-39 was recovered by reverting two non-conservative substitutions in the active site to those found …