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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
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1953 3
1959 1
1960 1
1964 2
1965 1
1974 1
1975 3
1976 3
1977 3
1978 5
1979 8
1980 7
1981 9
1982 14
1983 16
1984 19
1985 24
1986 16
1987 24
1988 22
1989 21
1990 23
1991 16
1992 21
1993 16
1994 15
1995 27
1996 20
1997 21
1998 19
1999 25
2000 26
2001 32
2002 18
2003 12
2004 25
2005 25
2006 17
2007 22
2008 18
2009 14
2010 21
2011 25
2012 25
2013 24
2014 21
2015 16
2016 19
2017 15
2018 16
2019 10
2020 13
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2023 6
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815 results

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Page 1
CAR-Ts redirected against the Thomsen-Friedenreich antigen CD176 mediate specific elimination of malignant cells from leukemia and solid tumors.
Dragon AC, Beermann LM, Umland M, Bonifacius A, Malinconico C, Ruhl L, Kehler P, Gellert J, Weiß L, Mayer-Hain S, Zimmermann K, Riese S, Thol F, Beutel G, Maecker-Kolhoff B, Yamamoto F, Blasczyk R, Schambach A, Hust M, Hudecek M, Eiz-Vesper B. Dragon AC, et al. Front Immunol. 2023 Oct 17;14:1219165. doi: 10.3389/fimmu.2023.1219165. eCollection 2023. Front Immunol. 2023. PMID: 37915564 Free PMC article.
Approximately 90% of carcinomas and leukemias are positive for the Thomsen-Friedenreich carbohydrate antigen CD176, which is associated with tumor progression, metastasis and therapy resistance. ...To target CD176, we generated two different 2(nd) gene …
Approximately 90% of carcinomas and leukemias are positive for the Thomsen-Friedenreich carbohydrate antigen CD176, whi …
Expression of MUC1 and CD176 (Thomsen-Friedenreich antigen) in papillary thyroid carcinomas.
Zhan XX, Zhao B, Diao C, Cao Y, Cheng RC. Zhan XX, et al. Endocr Pathol. 2015 Mar;26(1):21-6. doi: 10.1007/s12022-015-9356-9. Endocr Pathol. 2015. PMID: 25614211
The incidence of thyroid cancer has appeared as an increasing trend globally, especially in Asian countries. In this study, the expression of mucin-1 (MUC1) and Thomsen-Friedenreich antigen, Galbeta1-3GalNAcalpha1-R (CD176) was investigated by immunohistochem …
The incidence of thyroid cancer has appeared as an increasing trend globally, especially in Asian countries. In this study, the expression o …
Expression of CD176 (Thomsen-Friedenreich antigen) on lung, breast and liver cancer-initiating cells.
Lin WM, Karsten U, Goletz S, Cheng RC, Cao Y. Lin WM, et al. Int J Exp Pathol. 2011 Apr;92(2):97-105. doi: 10.1111/j.1365-2613.2010.00747.x. Epub 2010 Nov 11. Int J Exp Pathol. 2011. PMID: 21070402 Free PMC article.
Numerous studies have shown that the carbohydrate antigen structure CD176 (Thomsen-Friedenreich antigen, core-1) is present in many types of cancer and absent in normal adult human tissues. ...Co-expression of CD176 with CD133 was also detected, althou …
Numerous studies have shown that the carbohydrate antigen structure CD176 (Thomsen-Friedenreich antigen, core-1) is pre …
Tn-syndrome.
Berger EG. Berger EG. Biochim Biophys Acta. 1999 Oct 8;1455(2-3):255-68. doi: 10.1016/s0925-4439(99)00069-1. Biochim Biophys Acta. 1999. PMID: 10571017 Free article. Review.
Normally this residue is 3'-substituted by 5-galactose thereby forming the core 1 structure known as the Thomsen-Friedenreich (TF) antigen (Galbeta1 ==> 3GalNAcalpha1 ==> Thr/Ser). ...
Normally this residue is 3'-substituted by 5-galactose thereby forming the core 1 structure known as the Thomsen-Friedenreich …
Thomsen-friedenreich disaccharide immunogenicity.
Irazoqui FJ, Nores GA. Irazoqui FJ, et al. Curr Cancer Drug Targets. 2003 Dec;3(6):433-43. doi: 10.2174/1568009033481714. Curr Cancer Drug Targets. 2003. PMID: 14683501 Review.
Mucin-type O-glycans are upregulated and aberrantly glycosylated in many carcinomas. O-glycan Core 1 (Galbeta1-3GalNAcalpha-O-), also called Thomsen-Friedenreich disaccharide, is a cryptic structure overexpressed in cancer cells through modification of its glycosylt …
Mucin-type O-glycans are upregulated and aberrantly glycosylated in many carcinomas. O-glycan Core 1 (Galbeta1-3GalNAcalpha-O-), also called …
Anti-Thomsen-Friedenreich-Ag (anti-TF-Ag) potential for cancer therapy.
Almogren A, Abdullah J, Ghapure K, Ferguson K, Glinsky VV, Rittenhouse-Olson K. Almogren A, et al. Front Biosci (Schol Ed). 2012 Jan 1;4(3):840-63. doi: 10.2741/s304. Front Biosci (Schol Ed). 2012. PMID: 22202095 Free article. Review.
Thomsen-Friedenreich antigen (TF-Ag) is the disaccharide (Gal beta1-3 GalNAc alpha), which is also known as the core 1 structure. ...
Thomsen-Friedenreich antigen (TF-Ag) is the disaccharide (Gal beta1-3 GalNAc alpha), which is also known as the core 1 structu …
Evaluation of the anti-Thomsen-Friedenreich antibodies Nemod-TF1 and Nemod-TF2 as prognostic markers in breast cancer.
Heublein S, Egger M, Zhu J, Berger L, Mayr D, Schindlbeck C, Kuhn C, Hofmann SS, Schuetz F, Jeschke U, Ditsch N. Heublein S, et al. Breast Cancer Res Treat. 2020 Feb;179(3):643-652. doi: 10.1007/s10549-019-05503-6. Epub 2019 Dec 11. Breast Cancer Res Treat. 2020. PMID: 31828591
PURPOSE: The TF (Thomsen-Friedenreich, CD176, Galbeta1-3GalNAc) carbohydrate moiety is known as a specific oncofetal carbohydrate epitope present in fetal and neoplastic tissue as well as in stem cells. ...
PURPOSE: The TF (Thomsen-Friedenreich, CD176, Galbeta1-3GalNAc) carbohydrate moiety is known as a specific oncofetal ca …
Interaction of the Oncofetal Thomsen-Friedenreich Antigen with Galectins in Cancer Progression and Metastasis.
Sindrewicz P, Lian LY, Yu LG. Sindrewicz P, et al. Front Oncol. 2016 Mar 31;6:79. doi: 10.3389/fonc.2016.00079. eCollection 2016. Front Oncol. 2016. PMID: 27066458 Free PMC article. Review.
One of the most common glycosylation changes in epithelial cancer is the increased occurrence of the oncofetal Thomsen-Friedenreich disaccharide Galbeta1-3GalNAc (T or TF antigen), which appears in about 90% of cancers but is rarely seen in normal epithelium. ...
One of the most common glycosylation changes in epithelial cancer is the increased occurrence of the oncofetal Thomsen-Friedenreic …
Identification and Targeting of Thomsen-Friedenreich and IL1RAP Antigens on Chronic Myeloid Leukemia Stem Cells Using Bi-Specific Antibodies.
Eldesouki RE, Wu C, Saleh FM, Mohammed EA, Younes S, Hassan NE, Brown TC, Alt EU, Robinson JE, Badr FM, Braun SE. Eldesouki RE, et al. Onco Targets Ther. 2021 Jan 22;14:609-621. doi: 10.2147/OTT.S255299. eCollection 2021. Onco Targets Ther. 2021. PMID: 33519209 Free PMC article.
LSCs belong to the primitive population; CD34+CD38-Lin-, which does not distinguish normal hematopoietic stem cells (HSC) from CML LSCs. Because Thomsen-Friedenreich/CD176 antigen is expressed on CD34+ HSC and IL1RAP is tightly correlated to BCR-ABL expressio …
LSCs belong to the primitive population; CD34+CD38-Lin-, which does not distinguish normal hematopoietic stem cells (HSC) from CML LSCs. Bec …
Cluster binding studies with two anti-Thomsen-Friedenreich (anti-core-1, CD176, TF) antibodies: Evidence for a multiple TF epitope.
Flechner A, Butschak G, Löffler A, Rühmann J, Nishimura SI, Dölling R, Purfürst B, Goletz S, Danielczyk A, Karsten U. Flechner A, et al. Int Immunopharmacol. 2019 Jul;72:186-194. doi: 10.1016/j.intimp.2019.03.058. Epub 2019 Apr 15. Int Immunopharmacol. 2019. PMID: 30999209
We have examined the type of clusters recognized by two anti-Thomsen-Friedenreich (TF, core-1, CD176) IgM antibodies, NM-TF1 and NM-TF2, using several different sets of TF-carrying synthetic glycoconjugates in ELISA experiments. ...
We have examined the type of clusters recognized by two anti-Thomsen-Friedenreich (TF, core-1, CD176) IgM antibodies, N …
815 results