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1998 1
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127 results

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CCRL2 promotes antitumor T-cell immunity via amplifying TLR4-mediated immunostimulatory macrophage activation.
Yin W, Li Y, Song Y, Zhang J, Wu C, Chen Y, Miao Y, Lin C, Lin Y, Yan D, Chen J, He R. Yin W, et al. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2024171118. doi: 10.1073/pnas.2024171118. Proc Natl Acad Sci U S A. 2021. PMID: 33846258 Free PMC article.
However, whether CCRL2 influences macrophage function and regulates tumor immunity remains unknown. ...CCRL2 is selectively expressed in tumor-associated macrophages (TAM) with immunostimulatory phenotype in humans and mice. ...
However, whether CCRL2 influences macrophage function and regulates tumor immunity remains unknown. ...CCRL2 is selectively ex …
CCRL2 Expression by Specialized Lung Capillary Endothelial Cells Controls NK-cell Homing in Lung Cancer.
Sozio F, Schioppa T, Laffranchi M, Salvi V, Tamassia N, Bianchetto-Aguilera FM, Tiberio L, Bonecchi R, Bosisio D, Parmentier M, Bottazzi B, Leone R, Russo E, Bernardini G, Garofalo S, Limatola C, Gismondi A, Sciumè G, Mantovani A, Del Prete A, Sozzani S. Sozio F, et al. Cancer Immunol Res. 2023 Sep 1;11(9):1280-1295. doi: 10.1158/2326-6066.CIR-22-0951. Cancer Immunol Res. 2023. PMID: 37343073
C-C motif chemokine receptor-like 2 (CCRL2) is a nonsignaling seven-transmembrane domain receptor able to control lung tumor growth. ...In vivo administration of low doses of 5-Aza induced CCRL2 upregulation, increased recruitment of NK cells, and reduced lung tumor …
C-C motif chemokine receptor-like 2 (CCRL2) is a nonsignaling seven-transmembrane domain receptor able to control lung tumor growth. …
Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent beta2 integrin activation in monocytes.
Tang C, Chen G, Wu F, Cao Y, Yang F, You T, Liu C, Li M, Hu S, Ren L, Lu Q, Deng W, Xu Y, Wang G, Jo H, Zhang Y, Wu Y, Zabel BA, Zhu L. Tang C, et al. Cardiovasc Res. 2023 Aug 7;119(9):1811-1824. doi: 10.1093/cvr/cvad085. Cardiovasc Res. 2023. PMID: 37279540
We therefore investigated the role of CCRL2 and its ligand chemerin in atherosclerosis and the underlying mechanism. ...Using CCRL2-/-ApoE-/- mice, we showed that CCRL2 deficiency protected against plaque formation primarily in the d-flow areas of the aortic …
We therefore investigated the role of CCRL2 and its ligand chemerin in atherosclerosis and the underlying mechanism. ...Using CCRL …
Molecular Basis for CCRL2 Regulation of Leukocyte Migration.
Schioppa T, Sozio F, Barbazza I, Scutera S, Bosisio D, Sozzani S, Del Prete A. Schioppa T, et al. Front Cell Dev Biol. 2020 Dec 10;8:615031. doi: 10.3389/fcell.2020.615031. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 33363177 Free PMC article. Review.
CCRL2 is a seven-transmembrane domain receptor that belongs to the chemokine receptor family. ...The only commonly recognized CCRL2 ligand is chemerin, a non-chemokine chemotactic protein. CCRL2 is expressed both by leukocytes and non-hematopoietic cells. ...
CCRL2 is a seven-transmembrane domain receptor that belongs to the chemokine receptor family. ...The only commonly recognized CCRL …
CCRL2 affects the sensitivity of myelodysplastic syndrome and secondary acute myeloid leukemia cells to azacitidine.
Karantanos T, Teodorescu P, Arvanitis M, Perkins B, Jain T, DeZern AE, Dalton WB, Christodoulou I, Paun BC, Varadhan R, Esteb C, Rajkhowa T, Bonifant C, Gondek LP, Levis MJ, Yegnasubramanian S, Ghiaur G, Jones RJ. Karantanos T, et al. Haematologica. 2023 Jul 1;108(7):1886-1899. doi: 10.3324/haematol.2022.281444. Haematologica. 2023. PMID: 36519323 Free PMC article.
Furthermore, CCRL2 overexpression in MDS-L and TF-1 cells decreased their sensitivity to azacitidine. ...These results support CCRL2 targeting as having therapeutic potential in MDS/sAML....
Furthermore, CCRL2 overexpression in MDS-L and TF-1 cells decreased their sensitivity to azacitidine. ...These results support CCR …
Exploring CCRL2 chemerin binding using accelerated molecular dynamics.
Bufano M, Laffranchi M, Sozzani S, Raimondo D, Silvestri R, Coluccia A. Bufano M, et al. Proteins. 2022 Sep;90(9):1714-1720. doi: 10.1002/prot.26348. Epub 2022 Apr 29. Proteins. 2022. PMID: 35437825 Free PMC article.
Nevertheless, CCRL2 is unable to activate conventional G-protein dependent signaling and to induce cell directional migration. The only commonly accepted CCRL2 ligand is the nonchemokine chemotactic protein chemerin (RARRES2). ...
Nevertheless, CCRL2 is unable to activate conventional G-protein dependent signaling and to induce cell directional migration. The on …
CCRL2 Modulates Physiological and Pathological Angiogenesis During Retinal Development.
Ben Dhaou C, Del Prete A, Sozzani S, Parmentier M. Ben Dhaou C, et al. Front Cell Dev Biol. 2021 Dec 23;9:808455. doi: 10.3389/fcell.2021.808455. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 35004698 Free PMC article.
CCRL2 is expressed by many cell types including leukocyte subsets and endothelial cells, and its expression is strongly upregulated by inflammatory stimuli. ...CCRL2 appears therefore to regulate the distribution and concentration of chemerin in organs, regulating t …
CCRL2 is expressed by many cell types including leukocyte subsets and endothelial cells, and its expression is strongly upregulated b …
Ccrl2 deficiency deteriorates obesity and insulin resistance through increasing adipose tissue macrophages infiltration.
Xu M, Wang YM, Li WQ, Huang CL, Li J, Xie WH, Zeng HX, Tao LF, Li X. Xu M, et al. Genes Dis. 2020 Aug 31;9(2):429-442. doi: 10.1016/j.gendis.2020.08.009. eCollection 2022 Mar. Genes Dis. 2020. PMID: 35224158 Free PMC article.
In our study, we found ccrl2 expression significantly elevated in visceral adipose tissue (VAT) of high fat diet (HFD) induced obese mice and ob/ob mice. Systemic deletion of Ccrl2 gene aggravated HFD induced obesity and insulin resistance and ccrl2 (-/-) mic …
In our study, we found ccrl2 expression significantly elevated in visceral adipose tissue (VAT) of high fat diet (HFD) induced obese …
The role of the atypical chemokine receptor CCRL2 in myelodysplastic syndrome and secondary acute myeloid leukemia.
Karantanos T, Teodorescu P, Perkins B, Christodoulou I, Esteb C, Varadhan R, Helmenstine E, Rajkhowa T, Paun BC, Bonifant C, Dalton WB, Gondek LP, Moliterno AR, Levis MJ, Ghiaur G, Jones RJ. Karantanos T, et al. Sci Adv. 2022 Feb 18;8(7):eabl8952. doi: 10.1126/sciadv.abl8952. Epub 2022 Feb 18. Sci Adv. 2022. PMID: 35179961 Free PMC article.
CCRL2 coprecipitated with JAK2 and potentiated JAK2-STAT interaction. Erythroleukemia cells expressing JAK2V617F showed less effect of CCRL2 knockdown, whereas fedratinib potentiated the CCRL2 knockdown effect. ...
CCRL2 coprecipitated with JAK2 and potentiated JAK2-STAT interaction. Erythroleukemia cells expressing JAK2V617F showed less effect o …
Expression of CCRL2 Inhibits Tumor Growth by Concentrating Chemerin and Inhibiting Neoangiogenesis.
Al Delbany D, Robert V, Dubois-Vedrenne I, Del Prete A, Vernimmen M, Radi A, Lefort A, Libert F, Wittamer V, Sozzani S, Parmentier M. Al Delbany D, et al. Cancers (Basel). 2021 Oct 5;13(19):5000. doi: 10.3390/cancers13195000. Cancers (Basel). 2021. PMID: 34638484 Free PMC article.
CCRL2 belongs to the G protein-coupled receptor family and is one of the three chemerin receptors. ...Delayed tumor growth was also observed when B16 and LLC cells overexpress CCRL2, while knockout of Ccrl2 in tumor cells reversed the consequences of Ccrl2 …
CCRL2 belongs to the G protein-coupled receptor family and is one of the three chemerin receptors. ...Delayed tumor growth was also o …
127 results