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Page 1
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux.
Masud SN, Chandrashekhar M, Aregger M, Tan G, Zhang X, Mero P, Pirman DA, Zaslaver O, Smolen GA, Lin ZY, Wong CJ, Boone C, Gingras AC, Montenegro-Burke JR, Moffat J. Masud SN, et al. Nat Chem Biol. 2022 Dec;18(12):1370-1379. doi: 10.1038/s41589-022-01109-0. Epub 2022 Aug 15. Nat Chem Biol. 2022. PMID: 35970996
Interestingly, C1orf115/RDD1 was found to physically associate with ABCB1/MDR1 through proximity-labeling experiments and perturbation of C1orf115 led to mis-localization of ABCB1/MDR1. Our results are consistent with a model whereby C1orf115 modulates drug e …
Interestingly, C1orf115/RDD1 was found to physically associate with ABCB1/MDR1 through proximity-labeling experiments and perturbatio …
Systematic functional identification of cancer multi-drug resistance genes.
Lau MT, Ghazanfar S, Parkin A, Chou A, Rouaen JR, Littleboy JB, Nessem D, Khuong TM, Nevoltris D, Schofield P, Langley D, Christ D, Yang J, Pajic M, Neely GG. Lau MT, et al. Genome Biol. 2020 Feb 7;21(1):27. doi: 10.1186/s13059-020-1940-8. Genome Biol. 2020. PMID: 32028983 Free PMC article.
Importantly, we identified ten multi-drug resistance genes, including an uncharacterized gene C1orf115, which we named Required for Drug-induced Death 1 (RDD1). ...
Importantly, we identified ten multi-drug resistance genes, including an uncharacterized gene C1orf115, which we named Required for D …
Transcriptome sequencing of circular RNA reveals the involvement of hsa-SCMH1_0001 in the pathogenesis of Parkinson's disease.
Wang Q, Wang H, Zhao X, Han C, Liu C, Li Z, Du T, Sui Y, Zhang X, Zhang J, Xiao Y, Cai G, Meng F. Wang Q, et al. CNS Neurosci Ther. 2024 Mar;30(3):e14435. doi: 10.1111/cns.14435. Epub 2023 Sep 4. CNS Neurosci Ther. 2024. PMID: 37664885 Free PMC article.
We identified 17 potential binding miRNAs of hsa-SCMH1_0001 with 149 potential target genes. ARID1A and C1orf115 belong to the intersection of the predicted target genes and the differentially expressed mRNAs obtained by sequencing. CONCLUSION: This study suggested that hs …
We identified 17 potential binding miRNAs of hsa-SCMH1_0001 with 149 potential target genes. ARID1A and C1orf115 belong to the inters …
Predicting treatable traits for long-acting bronchodilators in patients with stable COPD.
Kang J, Kim KT, Lee JH, Kim EK, Kim TH, Yoo KH, Lee JS, Kim WJ, Kim JH, Oh YM. Kang J, et al. Int J Chron Obstruct Pulmon Dis. 2017 Dec 12;12:3557-3565. doi: 10.2147/COPD.S151909. eCollection 2017. Int J Chron Obstruct Pulmon Dis. 2017. PMID: 29263660 Free PMC article. Clinical Trial.
Traits associated with the treatment response to a LAMA were COPD assessment test score, BDR, expression of four genes (C1orf115, KIAA1618, PRKX, and RHOQ) and damage scores of three genes (FBN3, FDFT1, and ZBED6) (R(2)=0.575, p<0.001). ...
Traits associated with the treatment response to a LAMA were COPD assessment test score, BDR, expression of four genes (C1orf115, KIA …
Identification of novel biomarkers affecting the metastasis of colorectal cancer through bioinformatics analysis and validation through qRT-PCR.
Lian W, Jin H, Cao J, Zhang X, Zhu T, Zhao S, Wu S, Zou K, Zhang X, Zhang M, Zheng X, Peng M. Lian W, et al. Cancer Cell Int. 2020 Mar 30;20:105. doi: 10.1186/s12935-020-01180-4. eCollection 2020. Cancer Cell Int. 2020. PMID: 32256214 Free PMC article.
Especially, low expression of SULT1B1, MOGAT2 and C1orf115 were closely correlated with poorer survival of CRC. CONCLUSION: This study identified 5 genes as new biomarkers affecting the metastasis of CRC. Besides, SULT1B1, MOGAT2 and C1orf115 might be implicated in …
Especially, low expression of SULT1B1, MOGAT2 and C1orf115 were closely correlated with poorer survival of CRC. CONCLUSION: This stud …