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PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR.
J Clin Invest. 2007 Mar;117(3):730-8. doi: 10.1172/JCI28984. Epub 2007 Feb 8.
J Clin Invest. 2007.
PMID: 17290308
Free PMC article.
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.
Zhang H, Cicchetti G, Onda H, Koon HB, Asrican K, Bajraszewski N, Vazquez F, Carpenter CL, Kwiatkowski DJ.
Zhang H, et al. Among authors: bajraszewski n.
J Clin Invest. 2003 Oct;112(8):1223-33. doi: 10.1172/JCI17222.
J Clin Invest. 2003.
PMID: 14561707
Free PMC article.
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