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Page 1
The biology of SCUBE.
Lin YC, Sahoo BK, Gau SS, Yang RB. Lin YC, et al. J Biomed Sci. 2023 May 26;30(1):33. doi: 10.1186/s12929-023-00925-3. J Biomed Sci. 2023. PMID: 37237303 Free PMC article. Review.
The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial growth factor domain-containing protein] family consists of three proteins in vertebrates, SCUBE1, 2 and 3, which are highly conserved in zebrafish, mice and humans. ...For example, membrane-associat …
The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial growth factor domain-containing protein] family consists of …
Proteolysis of the low-density lipoprotein receptor in hepatocytes is mediated by BMP1 but not by other astacin proteases.
Kellett KAB, Fisher K, Aldworth H, Hooper NM. Kellett KAB, et al. FEBS Lett. 2023 Jun;597(11):1489-1502. doi: 10.1002/1873-3468.14667. Epub 2023 Jun 5. FEBS Lett. 2023. PMID: 37235726 Free PMC article.
Here, we aimed to determine whether astacin proteases other than BMP1 may also cleave LDLR. Although human hepatocytes express all six astacin proteases, including the meprins and mammalian tolloid, we found through pharmacological inhibition and genetic knockdown that onl …
Here, we aimed to determine whether astacin proteases other than BMP1 may also cleave LDLR. Although human hepatocytes express all si …
An exon 53 frameshift mutation in CUBN abrogates cubam function and causes Imerslund-Grasbeck syndrome in dogs.
Fyfe JC, Hemker SL, Venta PJ, Fitzgerald CA, Outerbridge CA, Myers SL, Giger U. Fyfe JC, et al. Mol Genet Metab. 2013 Aug;109(4):390-6. doi: 10.1016/j.ymgme.2013.05.006. Epub 2013 May 22. Mol Genet Metab. 2013. PMID: 23746554 Free PMC article.
The region included CUBN, the locus encoding cubilin, a peripheral membrane protein that in concert with AMN forms the functional intrinsic factor-cobalamin receptor expressed in ileum and a multi-ligand receptor in renal proximal tubules. Cobalamin malabsorption and prote …
The region included CUBN, the locus encoding cubilin, a peripheral membrane protein that in concert with AMN forms the functional intrinsic …
Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126.
Paavola KJ, Sidik H, Zuchero JB, Eckart M, Talbot WS. Paavola KJ, et al. Sci Signal. 2014 Aug 12;7(338):ra76. doi: 10.1126/scisignal.2005347. Sci Signal. 2014. PMID: 25118328 Free PMC article.
Type IV collagen specifically bound to the extracellular amino-terminal region of Gpr126 containing the CUB (complement, Uegf, Bmp1) and pentraxin domains. Gpr126 derivatives lacking the entire amino-terminal region were constitutively active, suggesting that this region i …
Type IV collagen specifically bound to the extracellular amino-terminal region of Gpr126 containing the CUB (complement, Uegf, Bmp1) …
Dentin matrix protein-1 isoforms promote differential cell attachment and migration.
von Marschall Z, Fisher LW. von Marschall Z, et al. J Biol Chem. 2008 Nov 21;283(47):32730-40. doi: 10.1074/jbc.M804283200. Epub 2008 Sep 25. J Biol Chem. 2008. PMID: 18819913 Free PMC article.
Although etiological mechanisms remain unclear, DMP1 is the only one of these three genes currently known to have mutations resulting in human disease, and yet it remains the least studied. ...The sequence specificity of the proposed BMP1-cleavage site of DMP1 was v …
Although etiological mechanisms remain unclear, DMP1 is the only one of these three genes currently known to have mutations resulting …
Inflammatory expression profile in peripheral blood mononuclear cells from patients with Nasu-Hakola Disease.
Galimberti D, Fenoglio C, Ghezzi L, Serpente M, Arcaro M, D'Anca M, De Riz M, Arighi A, Fumagalli GG, Pietroboni AM, Piccio L, Scarpini E. Galimberti D, et al. Cytokine. 2019 Apr;116:115-119. doi: 10.1016/j.cyto.2018.12.024. Epub 2019 Jan 25. Cytokine. 2019. PMID: 30690291
Homozygous mutations in Triggering Receptor Expressed on Myeloid cells 2 gene (TREM2) are one of the major causes of Nasu Hakola Disease (NHD). We analysed Peripheral Blood Mononuclear Cells (PBMC) profile of 164 inflammatory factors in patients with NHD carrying the TREM2 …
Homozygous mutations in Triggering Receptor Expressed on Myeloid cells 2 gene (TREM2) are one of the major causes of Nasu Hakola Dise …
The tolkin gene is a tolloid/BMP-1 homologue that is essential for Drosophila development.
Finelli AL, Xie T, Bossie CA, Blackman RK, Padgett RW. Finelli AL, et al. Genetics. 1995 Sep;141(1):271-81. doi: 10.1093/genetics/141.1.271. Genetics. 1995. PMID: 8536976 Free PMC article.
The genetic interactions between tolloid and dpp suggests a model in which the tolloid protein participates in a complex containing the DPP ligand, its protease serving to activate DPP, either directly or indirectly. ...Its overall structure is like tolloid, with an N-term …
The genetic interactions between tolloid and dpp suggests a model in which the tolloid protein participates in a complex containing the DPP …
The expression of twisted gastrulation in postnatal mouse brain and functional implications.
Sun M, Forsman C, Sergi C, Gopalakrishnan R, O'Connor MB, Petryk A. Sun M, et al. Neuroscience. 2010 Aug 25;169(2):920-31. doi: 10.1016/j.neuroscience.2010.05.026. Epub 2010 May 20. Neuroscience. 2010. PMID: 20493240 Free PMC article.
TWSG1 was also detected in a human fetal brain at mid-gestation, with highest levels in the epithelium of CP. Bmp1, Bmp2, Bmp4-Bmp7 as well as BmprIA and BmprII, but not BmprIB, were expressed in CP. ...
TWSG1 was also detected in a human fetal brain at mid-gestation, with highest levels in the epithelium of CP. Bmp1, Bmp2, Bmp4-Bmp7 a …
Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells.
Ustach CV, Kim HR. Ustach CV, et al. Mol Cell Biol. 2005 Jul;25(14):6279-88. doi: 10.1128/MCB.25.14.6279-6288.2005. Mol Cell Biol. 2005. PMID: 15988036 Free PMC article.
Platelet-derived growth factor (PDGF) protein family members are potent mitogens and chemoattractants for mesenchymal cells. The classic PDGF ligands A and B are single-domain protein chains which are secreted as active dimers capable of activating their cognate PDGF recep …
Platelet-derived growth factor (PDGF) protein family members are potent mitogens and chemoattractants for mesenchymal cells. The classic PDG …
Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells.
Zhang S, Fantozzi I, Tigno DD, Yi ES, Platoshyn O, Thistlethwaite PA, Kriett JM, Yung G, Rubin LJ, Yuan JX. Zhang S, et al. Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L740-54. doi: 10.1152/ajplung.00284.2002. Epub 2003 May 9. Am J Physiol Lung Cell Mol Physiol. 2003. PMID: 12740218 Free article.
Pulmonary vascular medial hypertrophy in primary pulmonary hypertension (PPH) is mainly caused by increased proliferation and decreased apoptosis in pulmonary artery smooth muscle cells (PASMCs). Mutations of the bone morphogenetic protein (BMP) receptor type II (BMP-RII) …
Pulmonary vascular medial hypertrophy in primary pulmonary hypertension (PPH) is mainly caused by increased proliferation and decreased apop …