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Did you mean blvr and metabolism and cancer (4 results)?
The physiology of bilirubin: health and disease equilibrium.
Vitek L, Hinds TD Jr, Stec DE, Tiribelli C. Vitek L, et al. Trends Mol Med. 2023 Apr;29(4):315-328. doi: 10.1016/j.molmed.2023.01.007. Epub 2023 Feb 22. Trends Mol Med. 2023. PMID: 36828710 Free PMC article. Review.
Current studies show that bilirubin also decreases adiposity and prevents metabolic and cardiovascular diseases. All in all, the physiological importance of bilirubin is only now coming to light, and strategies for increasing plasma bilirubin levels to combat chronic disea …
Current studies show that bilirubin also decreases adiposity and prevents metabolic and cardiovascular diseases. All in all, the phys …
Identification of monocyte-associated biomarkers in systemic lupus erythematosus and their pan-cancer analysis.
Chen H, He J, Wang L, Lin Y, Mou Z, Huang X, Chen L. Chen H, et al. Lupus. 2023 Oct;32(12):1369-1380. doi: 10.1177/09612033231204765. Epub 2023 Sep 28. Lupus. 2023. PMID: 37769649
Immune dysregulation is not only a pathogenic mechanism in systemic lupus erythematosus (SLE) but also a potential cause of the link between SLE and cancer. The current understanding of SLE monocyte-associated biomarkers is limited, and the precise mechanism behind the lin …
Immune dysregulation is not only a pathogenic mechanism in systemic lupus erythematosus (SLE) but also a potential cause of the link between …
Predictive role BLVRA mRNA expression in hepatocellular cancer.
Kubícková KN, Subhanová I, Konícková R, Matousová L, Urbánek P, Parobková H, Kupec M, Pudil J, Vítek L. Kubícková KN, et al. Ann Hepatol. 2016 Nov-Dec 2016;15(6):881-887. doi: 10.5604/16652681.1222104. Ann Hepatol. 2016. PMID: 27740521 Free article.
Gene expressions of heme oxygenase 1 (HMOX1), biliverdin reductase A/B (BLVRA/B), NADPH oxidase 2 (NOX2) and p22phox were analyzed in the liver and peripheral blood leukocytes (PBL) in the subjects. RESULTS: Compared to controls, almost a 3 times higher mRNA level of BL …
Gene expressions of heme oxygenase 1 (HMOX1), biliverdin reductase A/B (BLVRA/B), NADPH oxidase 2 (NOX2) and p22phox were analyzed in …
Protective effect of GK2 fused BLVRA protein against oxidative stress-induced dopaminergic neuronal cell damage.
Choi YJ, Kwon HJ, Shin MJ, Kim DW, Youn GS, Park JH, Yeo HJ, Yeo EJ, Kim HS, Lee LR, Kim NY, Kwon SY, Kim DS, Kim GW, Park J, Han KH, Lee KW, Park JK, Lee CH, Eum WS, Choi SY. Choi YJ, et al. FEBS J. 2023 Jun;290(11):2923-2938. doi: 10.1111/febs.16721. Epub 2023 Feb 8. FEBS J. 2023. PMID: 36688733
In this study, we developed a novel N-acetylgalactosamine kinase (GK2) protein transduction domain (PTD) derived from adenosine A2A and fused with BLVRA to determine whether the GK2-BLVRA fusion protein could protect dopaminergic neuronal cells (SH-SY5Y) from oxidat …
In this study, we developed a novel N-acetylgalactosamine kinase (GK2) protein transduction domain (PTD) derived from adenosine A2A and fuse …
Heme-Derived Metabolic Signals Dictate Immune Responses.
Canesin G, Hejazi SM, Swanson KD, Wegiel B. Canesin G, et al. Front Immunol. 2020 Jan 31;11:66. doi: 10.3389/fimmu.2020.00066. eCollection 2020. Front Immunol. 2020. PMID: 32082323 Free PMC article. Review.
Here we will discuss the role of heme-related immune response and the potential for targeting the heme system for therapies directed toward hepatitis and cancer....
Here we will discuss the role of heme-related immune response and the potential for targeting the heme system for therapies directed toward …
Cutting edge concepts: Does bilirubin enhance exercise performance?
Flack KD, Vítek L, Fry CS, Stec DE, Hinds TD Jr. Flack KD, et al. Front Sports Act Living. 2023 Jan 11;4:1040687. doi: 10.3389/fspor.2022.1040687. eCollection 2022. Front Sports Act Living. 2023. PMID: 36713945 Free PMC article. Review.
However, the mechanisms of these are unknown. Current research has re-defined bilirubin as a metabolic hormone that interacts with nuclear receptors to drive gene transcription, which reduces body weight. ...Here, we discuss the importance of bilirubin and exercise and how …
However, the mechanisms of these are unknown. Current research has re-defined bilirubin as a metabolic hormone that interacts with nu …
Metabolomic and Transcriptomic Profiling Identified Significant Genes in Thymic Epithelial Tumor.
Tang E, Zhou Y, Liu S, Zhang Z, Zhang R, Huang D, Gao T, Zhang T, Xu G. Tang E, et al. Metabolites. 2022 Jun 20;12(6):567. doi: 10.3390/metabo12060567. Metabolites. 2022. PMID: 35736499 Free PMC article.
Thymomas and thymic carcinomas are malignant thymic epithelial tumors (TETs) with poor outcomes if non-resectable. However, the tumorigenesis, especially the metabolic mechanisms involved, is poorly studied. Untargeted metabolomics analysis was utilized to screen for diffe …
Thymomas and thymic carcinomas are malignant thymic epithelial tumors (TETs) with poor outcomes if non-resectable. However, the tumorigenesi …
BLVRA exerts its biological effects to induce malignant properties of hepatocellular carcinoma cells via Wnt/beta-catenin pathway.
Chen X, Yang F, Zhang C, Wang X, Yuan C, Shi D, Zhu S, Zhang X, Chen X, Zhao W. Chen X, et al. J Mol Histol. 2024 Apr;55(2):159-167. doi: 10.1007/s10735-023-10179-w. Epub 2024 Jan 13. J Mol Histol. 2024. PMID: 38216836
Therefore, this research intends to explore the effect of BLVRA on HCC cells growth and metastasis. BLVRA expression was analyzed in public dataset and examined by using western blot. ...Analysis from GEPIA website showed that BLVRA expression was significant …
Therefore, this research intends to explore the effect of BLVRA on HCC cells growth and metastasis. BLVRA expression was analy …
Bilirubin Nanoparticle Treatment in Obese Mice Inhibits Hepatic Ceramide Production and Remodels Liver Fat Content.
Kipp ZA, Martinez GJ, Bates EA, Maharramov AB, Flight RM, Moseley HNB, Morris AJ, Stec DE, Hinds TD Jr. Kipp ZA, et al. Metabolites. 2023 Feb 1;13(2):215. doi: 10.3390/metabo13020215. Metabolites. 2023. PMID: 36837834 Free PMC article.
Studies have indicated that increasing plasma bilirubin levels might be useful for preventing and treating hepatic lipid accumulation that occurs with metabolic diseases such as obesity and diabetes. We have previously demonstrated that mice with hyperbilirubinemia had sig …
Studies have indicated that increasing plasma bilirubin levels might be useful for preventing and treating hepatic lipid accumulation that o …
Heme degradation enzyme biliverdin IXbeta reductase is required for stem cell glutamine metabolism.
Li Z, Nesbitt NM, Malone LE, Gnatenko DV, Wu S, Wang D, Zhu W, Girnun GD, Bahou WF. Li Z, et al. Biochem J. 2018 Mar 29;475(6):1211-1223. doi: 10.1042/BCJ20180016. Biochem J. 2018. PMID: 29500232 Free PMC article.
These collective data place heme catabolism in a crucial pathway of glutamine-regulated bioenergetic metabolism and suggest that early stages of lineage fate potential require glutamine anaplerotic functions and an intact PPP, which are, in part, regulated by BLVRB activit …
These collective data place heme catabolism in a crucial pathway of glutamine-regulated bioenergetic metabolism and suggest that earl …
13 results