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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 3
2001 4
2002 2
2003 1
2004 3
2005 1
2006 2
2009 1
2011 1
2012 2
2021 1
2022 2
2024 0

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20 results

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Page 1
Leaky scanning and reinitiation regulate BACE1 gene expression.
Zhou W, Song W. Zhou W, et al. Mol Cell Biol. 2006 May;26(9):3353-64. doi: 10.1128/MCB.26.9.3353-3364.2006. Mol Cell Biol. 2006. PMID: 16611980 Free PMC article.
The expression of the BACE1 gene is relatively low in vivo. The control of BACE1 expression has not been well defined. ...The fourth uAUG can function as a translation initiation codon, and deletion or mutation of this uAUG increases downstream gene expressio …
The expression of the BACE1 gene is relatively low in vivo. The control of BACE1 expression has not been well defined. ...The …
Urokinase-Type Plasminogen Activator Triggers Wingless/Int1-Independent Phosphorylation of the Low-Density Lipoprotein Receptor-Related Protein-6 in Cerebral Cortical Neurons.
Diaz A, Martin-Jimenez C, Woo Y, Merino P, Torre E, Yepes M. Diaz A, et al. J Alzheimers Dis. 2022;89(3):877-891. doi: 10.3233/JAD-220320. J Alzheimers Dis. 2022. PMID: 35964187
METHODS: We used in vitro cultures of murine cerebral cortical neurons, a murine neuroblastoma cell line transfected with the APP-695 Swedish mutation (N2asw), and mice deficient on either plasminogen, or uPA, or its receptor (uPAR). RESULTS: We show that uPA activates the …
METHODS: We used in vitro cultures of murine cerebral cortical neurons, a murine neuroblastoma cell line transfected with the APP-695 Swedis …
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase.
Six E, Ndiaye D, Laabi Y, Brou C, Gupta-Rossi N, Israel A, Logeat F. Six E, et al. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7638-43. doi: 10.1073/pnas.1230693100. Epub 2003 Jun 6. Proc Natl Acad Sci U S A. 2003. PMID: 12794186 Free PMC article.
The Notch receptor is a type I transmembrane (TM) protein that undergoes two proteolytic steps after ligand binding, first by an ADAM (a distintegrin and metalloprotease) in the extracellular region, followed by gamma-secretase-mediated cleavage inside the TM domain. We de …
The Notch receptor is a type I transmembrane (TM) protein that undergoes two proteolytic steps after ligand binding, first by an ADAM …
In-silico Studies and Biological Activity of Potential BACE-1 Inhibitors.
Arya R, Paliwal S, Gupta SP, Sharma S, Madan K, Mishra A, Verma K, Chauhan N. Arya R, et al. Comb Chem High Throughput Screen. 2021;24(5):729-736. doi: 10.2174/1386207323999200918151331. Comb Chem High Throughput Screen. 2021. PMID: 32957879
The pathological lesions and neuronal damage in the brain are caused by self-aggregated fragments of mutated Amyloidal precursor protein (APP). OBJECTIVE: The controlled APP processing by inhibition of secretase is the strategy to reduce Abeta load to treat Alzheimer's dis …
The pathological lesions and neuronal damage in the brain are caused by self-aggregated fragments of mutated Amyloidal precursor prot …
A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis.
Sambamurti K, Suram A, Venugopal C, Prakasam A, Zhou Y, Lahiri DK, Greig NH. Sambamurti K, et al. Curr Alzheimer Res. 2006 Feb;3(1):81-90. doi: 10.2174/156720506775697142. Curr Alzheimer Res. 2006. PMID: 16472208 Review.
This article presents a new hypothesis that takes into account the numerous familial AD (FAD) mutations in the amyloid precursor protein (APP) and its processing pathways, but suggests a new perspective beyond toxicity of forms of the amyloid beta-peptide (Abeta). ...Never …
This article presents a new hypothesis that takes into account the numerous familial AD (FAD) mutations in the amyloid precursor prot …
Implication of APP secretases in notch signaling.
Hartmann D, Tournoy J, Saftig P, Annaert W, De Strooper B. Hartmann D, et al. J Mol Neurosci. 2001 Oct;17(2):171-81. doi: 10.1385/JMN:17:2:171. J Mol Neurosci. 2001. PMID: 11816790 Review.
Signaling via notch receptors and their ligands is an evolutionary ancient and highly conserved mechanism governing cell-fate decisions throughout the animal kingdom. Upon ligand binding, notch receptors are subject to a two-step proteolysis essential for signal tra …
Signaling via notch receptors and their ligands is an evolutionary ancient and highly conserved mechanism governing cell-fate decisio …
α-Lipoic Acid Has the Potential to Normalize Copper Metabolism, Which Is Dysregulated in Alzheimer's Disease.
Metsla K, Kirss S, Laks K, Sildnik G, Palgi M, Palumaa T, Tõugu V, Palumaa P. Metsla K, et al. J Alzheimers Dis. 2022;85(2):715-728. doi: 10.3233/JAD-215026. J Alzheimers Dis. 2022. PMID: 34864665
OBJECTIVE: In the current study, we follow the widely accepted hypothesis that the normalization of copper metabolism leads to the prevention or slowing of the disease and search for new copper-regulating ligands. METHODS: We used cell culture, ICP MS, and Drosophila melan …
OBJECTIVE: In the current study, we follow the widely accepted hypothesis that the normalization of copper metabolism leads to the preventio …
Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Aβ metabolism.
Leal MC, Surace EI, Holgado MP, Ferrari CC, Tarelli R, Pitossi F, Wisniewski T, Castaño EM, Morelli L. Leal MC, et al. Biochim Biophys Acta. 2012 Feb;1823(2):227-35. doi: 10.1016/j.bbamcr.2011.09.014. Epub 2011 Oct 19. Biochim Biophys Acta. 2012. PMID: 22036964 Free PMC article.
Transient transfection of Notch intracellular domain (NICD) in N2aSW cells, mouse neuroblastoma cells (N2a) stably expressing human amyloid precursor protein (APP) Swedish mutation, reduce IDE mRNA levels, promoting extracellular Abeta accumulation. ...By site-directed mut …
Transient transfection of Notch intracellular domain (NICD) in N2aSW cells, mouse neuroblastoma cells (N2a) stably expressing human amyloid …
Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Weinmaster G, Selkoe DJ, Hyman BT. Berezovska O, et al. Ann N Y Acad Sci. 2000;920:223-6. doi: 10.1111/j.1749-6632.2000.tb06926.x. Ann N Y Acad Sci. 2000. PMID: 11193154
We now show, using mammalian cells transfected with full-length Notch1, that the C terminal domain of Notch1 rapidly translocates to the nucleus upon stimulation with the physiologic ligand Delta and initiates a CBF1-dependent signal transduction cascade. Using this assay, …
We now show, using mammalian cells transfected with full-length Notch1, that the C terminal domain of Notch1 rapidly translocates to the nuc …
20 results