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B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling.
Sreekumar A, Lu M, Choudhury B, Pan TC, Pant DK, Lawrence-Paul MR, Sterner CJ, Belka GK, Toriumi T, Benz BA, Escobar-Aguirre M, Marino FE, Esko JD, Chodosh LA. Sreekumar A, et al. Cancer Cell. 2024 Jan 8;42(1):52-69.e7. doi: 10.1016/j.ccell.2023.11.008. Epub 2023 Dec 7. Cancer Cell. 2024. PMID: 38065100
Breast cancer mortality results from incurable recurrences thought to be seeded by dormant, therapy-refractory residual tumor cells (RTCs). ...These findings implicate B3GALT6 in cancer and nominate FGFR2 inhibition as a promising approach to eradicate dorman …
Breast cancer mortality results from incurable recurrences thought to be seeded by dormant, therapy-refractory residual tumor cells ( …
Nine glycolysis-related gene signature predicting the survival of patients with endometrial adenocarcinoma.
Liu J, Li S, Feng G, Meng H, Nie S, Sun R, Yang J, Cheng W. Liu J, et al. Cancer Cell Int. 2020 May 24;20:183. doi: 10.1186/s12935-020-01264-1. eCollection 2020. Cancer Cell Int. 2020. PMID: 32489319 Free PMC article.
BACKGROUND: Endometrial cancer is the fourth most common cancer in women. The death rate for endometrial cancer has increased. ...The expression levels of B3GALT6, DCN, FBP2 and GYS2 are lower in tumor samples and higher in normal tissue samples. ...
BACKGROUND: Endometrial cancer is the fourth most common cancer in women. The death rate for endometrial cancer has inc …
Analytical validation of a novel multi-target blood-based test to detect hepatocellular carcinoma.
Johnson AM, Dudek JM, Edwards DK, Myers TA, Joseph P, Laffin JJ, Bruinsma JJ. Johnson AM, et al. Expert Rev Mol Diagn. 2021 Nov;21(11):1245-1252. doi: 10.1080/14737159.2021.1981290. Epub 2021 Oct 12. Expert Rev Mol Diagn. 2021. PMID: 34581651
METHODS: The multi-target HCC blood test (mt-HBT) integrates results from three DNA methylation markers (HOXA1, TSPYL5, and B3GALT6), the protein biomarker alpha-fetoprotein (AFP), and patient sex. ...
METHODS: The multi-target HCC blood test (mt-HBT) integrates results from three DNA methylation markers (HOXA1, TSPYL5, and B3GALT6), …
1p36 deletion results in a decrease in glycosaminoglycans which is associated with aggressiveness in neuroblastic tumors.
Tadeo I, Gamero-Sandemetrio E, Berbegall AP, Navarro S, Cañete A, Noguera R. Tadeo I, et al. Histol Histopathol. 2018 May;33(5):487-495. doi: 10.14670/HH-11-947. Epub 2017 Nov 23. Histol Histopathol. 2018. PMID: 29168879
We also studied the relationship between the density of extracellular matrix glycosaminoglycans and the expression of B3GALT6, an enzyme required for their synthesis. We associated a decrease in glycosaminoglycans with neuroblastomas that were histopathologically poorly-di …
We also studied the relationship between the density of extracellular matrix glycosaminoglycans and the expression of B3GALT6, an enz …
Hepatocellular Carcinoma Detection by Plasma Methylated DNA: Discovery, Phase I Pilot, and Phase II Clinical Validation.
Kisiel JB, Dukek BA, V S R Kanipakam R, Ghoz HM, Yab TC, Berger CK, Taylor WR, Foote PH, Giama NH, Onyirioha K, Abdallah MA, Burger KN, Slettedahl SW, Mahoney DW, Smyrk TC, Lewis JT, Giakoumopoulos M, Allawi HT, Lidgard GP, Roberts LR, Ahlquist DA. Kisiel JB, et al. Hepatology. 2019 Mar;69(3):1180-1192. doi: 10.1002/hep.30244. Epub 2019 Feb 5. Hepatology. 2019. PMID: 30168613 Free PMC article. Clinical Trial.
In phase II, a six-marker MDM panel (homeobox A1 [HOXA1], empty spiracles homeobox 1 [EMX1], AK055957, endothelin-converting enzyme 1 [ECE1], phosphofructokinase [PFKP], and C-type lectin domain containing 11A [CLEC11A]) normalized by beta-1,3-galactosyltransferase 6 (B3GALT6
In phase II, a six-marker MDM panel (homeobox A1 [HOXA1], empty spiracles homeobox 1 [EMX1], AK055957, endothelin-converting enzyme 1 [ECE1] …