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1994 2
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33 results

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Mechanisms of artemether toxicity on single cardiomyocytes and protective effect of nanoencapsulation.
Moreira Souza AC, Grabe-Guimarães A, Cruz JDS, Santos-Miranda A, Farah C, Teixeira Oliveira L, Lucas A, Aimond F, Sicard P, Mosqueira VCF, Richard S. Moreira Souza AC, et al. Br J Pharmacol. 2020 Oct;177(19):4448-4463. doi: 10.1111/bph.15186. Epub 2020 Aug 24. Br J Pharmacol. 2020. PMID: 32608017 Free PMC article.
Artemether in nanocapsules (NC-ATM) is more efficient than free artemether for reducing parasitaemia and increasing survival of Plasmodium berghei-infected mice. NCs also prevent prolongation of the QT interval of the ECG. Here, we assessed cellular cardiotox
Artemether in nanocapsules (NC-ATM) is more efficient than free artemether for reducing parasitaemia and increasing survival o
Drug interactions with antimalarial medications in older travelers: a clinical guide.
Lewis J, Gregorian T, Portillo I, Goad J. Lewis J, et al. J Travel Med. 2020 Feb 3;27(1):taz089. doi: 10.1093/jtm/taz089. J Travel Med. 2020. PMID: 31776555 Free article. Review.
Antimalarial drug-disease interactions in older adults can occur more often due to QT prolongation, exacerbation of hypoglycemia, decreased renal elimination and decreased hepatic metabolism. ...
Antimalarial drug-disease interactions in older adults can occur more often due to QT prolongation, exacerbation of hypoglycemia, dec …
Reduced cardiotoxicity and increased oral efficacy of artemether polymeric nanocapsules in Plasmodium berghei-infected mice.
Souza ACM, Mosqueira VCF, Silveira APA, Antunes LR, Richard S, Guimarães HN, Grabe-Guimarães A. Souza ACM, et al. Parasitology. 2018 Jul;145(8):1075-1083. doi: 10.1017/S0031182017002207. Epub 2017 Dec 10. Parasitology. 2018. PMID: 29223181
Artemether (ATM) cardiotoxicity, its short half-life and low oral bioavailability are the major limiting factors for its use to treat malaria. ...ATM-NC improved antimalarial in vivo efficacy and reduced mice mortality. Free-ATM induced significantly QT and QTc inte
Artemether (ATM) cardiotoxicity, its short half-life and low oral bioavailability are the major limiting factors for its use to treat
Plasmodium falciparum gametocyte dynamics after pyronaridine-artesunate or artemether-lumefantrine treatment.
Roth JM, Sawa P, Omweri G, Osoti V, Makio N, Bradley J, Bousema T, Schallig HDFH, Mens PF. Roth JM, et al. Malar J. 2018 Jun 4;17(1):223. doi: 10.1186/s12936-018-2373-7. Malar J. 2018. PMID: 29866116 Free PMC article. Clinical Trial.
Duration of gametocyte carriage, the female and male gametocyte response and the agreement between qRT-PCR and QT-NASBA were determined. RESULTS: The mean duration of female gametocyte carriage was significantly longer for PA (4.9 days) than for AL (3.8 days) as estimated …
Duration of gametocyte carriage, the female and male gametocyte response and the agreement between qRT-PCR and QT-NASBA were determin …
Effects of Dihydroartemisinin-Piperaquine Phosphate and Artemether-Lumefantrine on QTc Interval Prolongation.
Funck-Brentano C, Bacchieri A, Valentini G, Pace S, Tommasini S, Voiriot P, Ubben D, Duparc S, Evene E, Felices M, Corsi M. Funck-Brentano C, et al. Sci Rep. 2019 Jan 28;9(1):777. doi: 10.1038/s41598-018-37112-6. Sci Rep. 2019. PMID: 30692558 Free PMC article.
QT/QTc interval prolongation reflects delayed cardiac repolarization which can lead to Torsade de Pointes and sudden death. ...We compared the effects of dihydroartemisinin-piperaquine phosphate (DHA-PQP) and artemether-lumefantrine (A-L) on QT interva
QT/QTc interval prolongation reflects delayed cardiac repolarization which can lead to Torsade de Pointes and sudden death. ..
A randomized trial to monitor the efficacy and effectiveness by QT-NASBA of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated Plasmodium falciparum malaria in western Kenya.
Mens PF, Sawa P, van Amsterdam SM, Versteeg I, Omar SA, Schallig HD, Kager PA. Mens PF, et al. Malar J. 2008 Nov 18;7:237. doi: 10.1186/1475-2875-7-237. Malar J. 2008. PMID: 19017387 Free PMC article. Clinical Trial.
Interaction between artemether-lumefantrine and nevirapine-based antiretroviral therapy in HIV-1-infected patients.
Kredo T, Mauff K, Van der Walt JS, Wiesner L, Maartens G, Cohen K, Smith P, Barnes KI. Kredo T, et al. Antimicrob Agents Chemother. 2011 Dec;55(12):5616-23. doi: 10.1128/AAC.05265-11. Epub 2011 Sep 26. Antimicrob Agents Chemother. 2011. PMID: 21947399 Free PMC article. Clinical Trial.

Combined artemether and dihydroartemisinin exposure decreased over time only in the nevirapine group (geometric mean ratio [GMR], 0.76 [95% confidence interval {CI}, 0.65 to 0.90]; P < 0.0001) and increased with the weight-adjusted artemether dose (GMR, 2.12 [95%

Combined artemether and dihydroartemisinin exposure decreased over time only in the nevirapine group (geometric mean ratio [GMR], 0.7 …
Electrocardiographic effect of artemisinin-piperaquine, dihydroartemisinin-piperaquine, and artemether-lumefantrine treatment in falciparum malaria patients.
Wu W, Lu C, Liang Y, Zhang H, Deng C, Wang Q, Xu Q, Tan B, Zhou C, Song J. Wu W, et al. Rev Soc Bras Med Trop. 2021 Feb 10;54:e05362020. doi: 10.1590/0037-8682-0536-2020. eCollection 2021. Rev Soc Bras Med Trop. 2021. PMID: 33605379 Free PMC article.
Electrocardiograms and other indicators were recorded before and after the treatment. The QT interval was calculated using Fridericia's formula (QTcF) and Bazett's formula (QTcB). ...CONCLUSIONS: Clinically recommended doses of DP, AL, and AP may cause QT prolongati …
Electrocardiograms and other indicators were recorded before and after the treatment. The QT interval was calculated using Fridericia …
Dihydroartemisinin/Piperaquine: a review of its use in the treatment of uncomplicated Plasmodium falciparum malaria.
Keating GM. Keating GM. Drugs. 2012 May 7;72(7):937-61. doi: 10.2165/11203910-000000000-00000. Drugs. 2012. PMID: 22515619 Review.
Two pivotal, randomized, open-label, multicentre trials demonstrated the Eurartesim formulation of dihydroartemisinin/piperaquine to be noninferior to artesunate plus mefloquine in children and adults in Asia and noninferior to artemether/lumefantrine in children in Africa …
Two pivotal, randomized, open-label, multicentre trials demonstrated the Eurartesim formulation of dihydroartemisinin/piperaquine to be noni …
Polyester Nanocapsules for Intravenous Delivery of Artemether: Formulation Development, Antimalarial Efficacy, and Cardioprotective Effects In Vivo.
Vidal-Diniz AT, Guimarães HN, Garcia GM, Braga ÉM, Richard S, Grabe-Guimarães A, Mosqueira VCF. Vidal-Diniz AT, et al. Polymers (Basel). 2022 Dec 15;14(24):5503. doi: 10.3390/polym14245503. Polymers (Basel). 2022. PMID: 36559869 Free PMC article.
Artemether (ATM) is an effective antimalarial drug that also has a short half-life in the blood. ...In healthy rats, IV administration of single doses of free-ATM (40 or 80 mg/kg) prolonged cardiac QT and QTc intervals and induced both bradycardia and hypotension. .
Artemether (ATM) is an effective antimalarial drug that also has a short half-life in the blood. ...In healthy rats, IV administratio
33 results