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Altered Neuronal and Circuit Excitability in Fragile X Syndrome.
Contractor A, Klyachko VA, Portera-Cailliau C. Contractor A, et al. Neuron. 2015 Aug 19;87(4):699-715. doi: 10.1016/j.neuron.2015.06.017. Neuron. 2015. PMID: 26291156 Free PMC article. Review.
Fragile X syndrome (FXS) results from a genetic mutation in a single gene yet produces a phenotypically complex disorder with a range of neurological and psychiatric problems. ...Contributions of these processes are often brain region and cell type specific, …
Fragile X syndrome (FXS) results from a genetic mutation in a single gene yet produces a phenotypically complex disorde …
Hyperexcitability and Homeostasis in Fragile X Syndrome.
Liu X, Kumar V, Tsai NP, Auerbach BD. Liu X, et al. Front Mol Neurosci. 2022 Jan 6;14:805929. doi: 10.3389/fnmol.2021.805929. eCollection 2021. Front Mol Neurosci. 2022. PMID: 35069112 Free PMC article.
Fragile X Syndrome (FXS) is a leading inherited cause of autism and intellectual disability, resulting from a mutation in the FMR1 gene and subsequent loss of its protein product FMRP. ...The mechanisms for hyperexcitability in FXS include alterations …
Fragile X Syndrome (FXS) is a leading inherited cause of autism and intellectual disability, resulting from a mutation …
Interneuron Dysfunction and Inhibitory Deficits in Autism and Fragile X Syndrome.
Nomura T. Nomura T. Cells. 2021 Oct 1;10(10):2610. doi: 10.3390/cells10102610. Cells. 2021. PMID: 34685590 Free PMC article. Review.
Fragile X syndrome (FXS) is a single-gene disorder that is the most common known cause of ASD. ...Accumulated evidence implicates deficits in the inhibitory circuits in FXS that tips E-I balance toward excitation. Deficits in interneurons, the m …
Fragile X syndrome (FXS) is a single-gene disorder that is the most common known cause of ASD. ...Accumulated evidence …
Structural and Functional Abnormalities in the Olfactory System of Fragile X Syndrome Models.
Bodaleo F, Tapia-Monsalves C, Cea-Del Rio C, Gonzalez-Billault C, Nunez-Parra A. Bodaleo F, et al. Front Mol Neurosci. 2019 May 28;12:135. doi: 10.3389/fnmol.2019.00135. eCollection 2019. Front Mol Neurosci. 2019. PMID: 31191246 Free PMC article. Review.
Fragile X Syndrome (FXS) is the most common inherited form of intellectual disability. ...This feature in combination with the exquisitely organized neuronal circuits found throughout the olfactory system (OS) and the wide expression of FMRP in …
Fragile X Syndrome (FXS) is the most common inherited form of intellectual disability. ...This feature in combination w …
Fragile X Syndrome as an interneuronopathy: a lesson for future studies and treatments.
Tempio A, Boulksibat A, Bardoni B, Delhaye S. Tempio A, et al. Front Neurosci. 2023 Apr 28;17:1171895. doi: 10.3389/fnins.2023.1171895. eCollection 2023. Front Neurosci. 2023. PMID: 37188005 Free PMC article. Review.
Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability (ID) and a primary genetic cause of autism spectrum disorder (ASD). ...Dendritic spine stability, branching and density abnormalities are part of the developmental delay obs …
Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability (ID) and a primary genetic cause …
Chloride imbalance in Fragile X syndrome.
Miles KD, Doll CA. Miles KD, et al. Front Neurosci. 2022 Oct 12;16:1008393. doi: 10.3389/fnins.2022.1008393. eCollection 2022. Front Neurosci. 2022. PMID: 36312023 Free PMC article.
Developmental changes in ionic balance are associated with crucial hallmarks in neural circuit formation, including changes in excitation and inhibition, neurogenesis, and synaptogenesis. Neuronal excitability is largely mediated by ionic concentration …
Developmental changes in ionic balance are associated with crucial hallmarks in neural circuit formation, including changes in exc …
Altered dendritic spine function and integration in a mouse model of fragile X syndrome.
Booker SA, Domanski APF, Dando OR, Jackson AD, Isaac JTR, Hardingham GE, Wyllie DJA, Kind PC. Booker SA, et al. Nat Commun. 2019 Oct 23;10(1):4813. doi: 10.1038/s41467-019-11891-6. Nat Commun. 2019. PMID: 31645626 Free PMC article.
Cellular and circuit hyperexcitability are core features of fragile X syndrome and related autism spectrum disorder models. However, the cellular and synaptic bases of this hyperexcitability have proved elusive. We report in a mouse model of fragile …
Cellular and circuit hyperexcitability are core features of fragile X syndrome and related autism spectrum disor …
Fmrp regulates neuronal balance in embryonic motor circuit formation.
Barker CM, Miles KD, Doll CA. Barker CM, et al. Front Neurosci. 2022 Nov 3;16:962901. doi: 10.3389/fnins.2022.962901. eCollection 2022. Front Neurosci. 2022. PMID: 36408418 Free PMC article.
Specialized spinal interneurons modulate and synchronize motor neuron activity to achieve coordinated motor output. Changes in the ratios and connectivity of spinal interneurons could drastically alter motor output by tipping the balance of inhibition and excitat …
Specialized spinal interneurons modulate and synchronize motor neuron activity to achieve coordinated motor output. Changes in the ra …
Do Astrocytes Play a Role in Intellectual Disabilities?
Cresto N, Pillet LE, Billuart P, Rouach N. Cresto N, et al. Trends Neurosci. 2019 Aug;42(8):518-527. doi: 10.1016/j.tins.2019.05.011. Epub 2019 Jul 9. Trends Neurosci. 2019. PMID: 31300246 Review.
Neurodevelopmental disorders, including those involving intellectual disability, are characterized by abnormalities in formation and functions of synaptic circuits. Traditionally, research on synaptogenesis and synaptic transmission in health and disease focused on neur …
Neurodevelopmental disorders, including those involving intellectual disability, are characterized by abnormalities in formation and functio …
Local cortical circuit correlates of altered EEG in the mouse model of Fragile X syndrome.
Goswami S, Cavalier S, Sridhar V, Huber KM, Gibson JR. Goswami S, et al. Neurobiol Dis. 2019 Apr;124:563-572. doi: 10.1016/j.nbd.2019.01.002. Epub 2019 Jan 9. Neurobiol Dis. 2019. PMID: 30639292 Free PMC article.
Electroencephalogram (EEG) recordings in Fragile X syndrome (FXS) patients have revealed enhanced sensory responses, enhanced resting "gamma frequency" (30-100 Hz) activity, and a decreased ability for sensory stimuli to modulate cortical activity at gamma fr …
Electroencephalogram (EEG) recordings in Fragile X syndrome (FXS) patients have revealed enhanced sensory responses, en …
23 results