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ATP receptors in pain sensation: Involvement of spinal microglia and P2X(4) receptors.
Inoue K, Tsuda M, Koizumi S. Inoue K, et al. Purinergic Signal. 2005 Jun;1(2):95-100. doi: 10.1007/s11302-005-6210-4. Epub 2005 Mar 17. Purinergic Signal. 2005. PMID: 18404495 Free PMC article.
An important advance in our understanding of the mechanisms involved in neuropathic pain has been made by a recent work demonstrating the crucial role of ATP receptors (i.e., P2X(3) and P2X(4) receptors). In this review, we summarize the role of …
An important advance in our understanding of the mechanisms involved in neuropathic pain has been made by a recent work demons …
BDNF in Neuropathic Pain; the Culprit that Cannot be Apprehended.
Smith PA. Smith PA. Neuroscience. 2024 Apr 5;543:49-64. doi: 10.1016/j.neuroscience.2024.02.020. Epub 2024 Feb 28. Neuroscience. 2024. PMID: 38417539 Review.
These transform the phenotype of dorsal horn microglia such that they express P2X4 purinoceptors. Activation of these receptors by neuron-derived ATP promotes BDNF release. ...The weight of evidence from male rodents suggests that this preferential mod …
These transform the phenotype of dorsal horn microglia such that they express P2X4 purinoceptors. Activation of these recep …
Modification of neuropathic pain sensation through microglial ATP receptors.
Inoue K, Tsuda M, Tozaki-Saitoh H. Inoue K, et al. Purinergic Signal. 2007 Sep;3(4):311-6. doi: 10.1007/s11302-007-9071-1. Epub 2007 Aug 25. Purinergic Signal. 2007. PMID: 18404444 Free PMC article.
Accumulating findings also indicate that nucleotides play an important role in neuron-glia communication through P2 purinoceptors. Damaged neurons release or leak nucleotides including ATP and UTP to stimulate microglia through P2 purinoceptors express …
Accumulating findings also indicate that nucleotides play an important role in neuron-glia communication through P2 purinoceptors. Da …
BK channels in microglia are required for morphine-induced hyperalgesia.
Hayashi Y, Morinaga S, Zhang J, Satoh Y, Meredith AL, Nakata T, Wu Z, Kohsaka S, Inoue K, Nakanishi H. Hayashi Y, et al. Nat Commun. 2016 May 31;7:11697. doi: 10.1038/ncomms11697. Nat Commun. 2016. PMID: 27241733 Free PMC article.
Although morphine is a gold standard medication, long-term opioid use is associated with serious side effects, such as morphine-induced hyperalgesia (MIH) and anti-nociceptive tolerance. Microglia-to-neuron signalling is critically involved in pain hypersensi …
Although morphine is a gold standard medication, long-term opioid use is associated with serious side effects, such as morphine-induced hype …