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Year Number of Results
2006 1
2008 1
2009 1
2010 2
2011 1
2012 2
2013 1
2014 1
2016 2
2017 3
2018 2
2019 5
2020 1
2021 6
2022 5
2023 5
2024 5

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39 results

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Page 1
Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart.
Nakayama Y, Mukai N, Kreitzer G, Patwari P, Yoshioka J. Nakayama Y, et al. Circ Res. 2022 Sep 2;131(6):510-527. doi: 10.1161/CIRCRESAHA.122.321351. Epub 2022 Aug 11. Circ Res. 2022. PMID: 35950500 Free PMC article.
To define the in vivo function of ARRDC4, we generated and characterized a novel Arrdc4 knockout (KO) mouse model. ...At baseline, Arrdc4-KO mice have mild fasting hypoglycemia. Arrdc4-KO hearts exhibit a robust increase in myocardial glucose uptake an …
To define the in vivo function of ARRDC4, we generated and characterized a novel Arrdc4 knockout (KO) mouse model. ...At basel …
Arrdc4-dependent extracellular vesicle biogenesis is required for sperm maturation.
Foot NJ, Gonzalez MB, Gembus K, Fonseka P, Sandow JJ, Nguyen TT, Tran D, Webb AI, Mathivanan S, Robker RL, Kumar S. Foot NJ, et al. J Extracell Vesicles. 2021 Jun;10(8):e12113. doi: 10.1002/jev2.12113. Epub 2021 Jun 22. J Extracell Vesicles. 2021. PMID: 34188787 Free PMC article.
Here we show that Arrdc4-mediated extracellular vesicle biogenesis is required for proper sperm function. ...We found a significant reduction in extracellular vesicle production by Arrdc4(-/-) epididymal epithelial cells, and further, supplementation of Arrdc4 …
Here we show that Arrdc4-mediated extracellular vesicle biogenesis is required for proper sperm function. ...We found a significant r …
K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis.
Farooq AU, Gembus K, Sandow JJ, Webb A, Mathivanan S, Manning JA, Shah SS, Foot NJ, Kumar S. Farooq AU, et al. J Extracell Vesicles. 2022 Feb;11(2):e12188. doi: 10.1002/jev2.12188. J Extracell Vesicles. 2022. PMID: 35106941 Free PMC article.
Here we report that ubiquitination of Arrdc4 is critical for its role in EV secretion. We identified five potential ubiquitinated lysine residues in Arrdc4 using mass spectrometry. By analysing Arrdc4 lysine mutants we discovered that lysine 270 (K270) is cri …
Here we report that ubiquitination of Arrdc4 is critical for its role in EV secretion. We identified five potential ubiquitinated lys …
ARRDC4 and UBXN1: Novel Target Genes Correlated with Prostate Cancer Gleason Score.
Oh JJ, Ho JN, Byun SS. Oh JJ, et al. Cancers (Basel). 2021 Oct 17;13(20):5209. doi: 10.3390/cancers13205209. Cancers (Basel). 2021. PMID: 34680357 Free PMC article.
The knockdown of UBXN1 and ARRDC4 led to significantly reduced cell proliferation and suppressed migration and invasiveness in PCa cell lines. Epithelial mesenchymal transition (EMT) markers were significantly down-regulated in si-ARRDC4 and si-UBXN1-transfected cel …
The knockdown of UBXN1 and ARRDC4 led to significantly reduced cell proliferation and suppressed migration and invasiveness in PCa ce …
ARRDC4 regulates enterovirus 71-induced innate immune response by promoting K63 polyubiquitination of MDA5 through TRIM65.
Meng J, Yao Z, He Y, Zhang R, Zhang Y, Yao X, Yang H, Chen L, Zhang Z, Zhang H, Bao X, Hu G, Wu T, Cheng J. Meng J, et al. Cell Death Dis. 2017 Jun 8;8(6):e2866. doi: 10.1038/cddis.2017.257. Cell Death Dis. 2017. PMID: 28594402 Free PMC article.
The expression level of ARRDC4 was positively correlated with the serum concentration of IL-6, TNF-alpha and CCL3 in clinical specimens. ...Our data highlight new function of ARRDC4 in innate immunity, contributing to the better understanding about regulation of MDA …
The expression level of ARRDC4 was positively correlated with the serum concentration of IL-6, TNF-alpha and CCL3 in clinical specime …
Brusatol suppresses the tumor growth and metastasis of colorectal cancer via upregulating ARRDC4 expression through modulating PI3K/YAP1/TAZ Pathway.
Huang QH, Zhang J, Cho WCS, Huang Y, Yang W, Zuo Z, Xian YF, Lin ZX. Huang QH, et al. Phytomedicine. 2023 Jan;109:154567. doi: 10.1016/j.phymed.2022.154567. Epub 2022 Nov 25. Phytomedicine. 2023. PMID: 36610120
Microarray analysis demonstrated that BR treatment markedly increased the gene expression of ARRDC4 in CRC cells. ARRDC4 was significantly repressed in CRC in the clinical samples and GEPIA analysis. ARRDC4 overexpression plus BR produced better inhibitory ef …
Microarray analysis demonstrated that BR treatment markedly increased the gene expression of ARRDC4 in CRC cells. ARRDC4 was s …
An insulin-regulated arrestin domain protein controls hepatic glucagon action.
Dagdeviren S, Hoang MF, Sarikhani M, Meier V, Benoit JC, Okawa MC, Melnik VY, Ricci-Blair EM, Foot N, Friedline RH, Hu X, Tauer LA, Srinivasan A, Prigozhin MB, Shenoy SK, Kumar S, Kim JK, Lee RT. Dagdeviren S, et al. J Biol Chem. 2023 Aug;299(8):105045. doi: 10.1016/j.jbc.2023.105045. Epub 2023 Jul 13. J Biol Chem. 2023. PMID: 37451484 Free PMC article.
Mice lacking ARRDC4 exhibited lower glucose levels after fasting and could not suppress gluconeogenesis at the refed state. We also show that ARRDC4 coimmunoprecipitates with the glucagon receptor, and ARRDC4 expression is suppressed by insulin. ...
Mice lacking ARRDC4 exhibited lower glucose levels after fasting and could not suppress gluconeogenesis at the refed state. We also s …
TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
Wang H, Wei W, Zhang ZY, Liu Y, Shi B, Zhong W, Zhang HS, Fang X, Sun CL, Wang JB, Liu LX. Wang H, et al. Cell Death Dis. 2021 Dec 17;13(1):3. doi: 10.1038/s41419-021-04459-0. Cell Death Dis. 2021. PMID: 34916487 Free PMC article.
Here, we report that METTL14, a key component of m6A methylation, is functionally related to the inhibition of ARRDC4/ZEB1 signaling and to the consequent suppression of CRC metastasis. We unveil METTL14-mediated m6A modification profile and identify ARRDC4 as a dir …
Here, we report that METTL14, a key component of m6A methylation, is functionally related to the inhibition of ARRDC4/ZEB1 signaling …
Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes.
Liu J, Meng L, Liu Z, Lu M, Wang R. Liu J, et al. Sci Rep. 2024 Mar 25;14(1):7083. doi: 10.1038/s41598-024-57794-5. Sci Rep. 2024. PMID: 38528189 Free PMC article.
A total of 2094 IR-DEGs were primarily enriched in response to endoplasmic reticulum stress. Importantly, HDAC9 and ARRDC4 were identified as markers of T2D and associated with different levels of immune cell infiltration. HDAC9 mRNA level were higher in the IR mice than i …
A total of 2094 IR-DEGs were primarily enriched in response to endoplasmic reticulum stress. Importantly, HDAC9 and ARRDC4 were ident …
39 results