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Cytidine deaminases APOBEC3C and APOBEC3D promote DNA replication stress resistance in pancreatic cancer cells.
Ubhi T, Zaslaver O, Quaile AT, Plenker D, Cao P, Pham NA, Békési A, Jang GH, O'Kane GM, Notta F, Moffat J, Wilson JM, Gallinger S, Vértessy BG, Tuveson DA, Röst HL, Brown GW. Ubhi T, et al. Nat Cancer. 2024 Mar 6. doi: 10.1038/s43018-024-00742-z. Online ahead of print. Nat Cancer. 2024. PMID: 38448522
Here, to define the cancer cell response to gemcitabine, we performed genome-scale CRISPR-Cas9 chemical-genetic screens in PDAC cells and found selective loss of cell fitness upon disruption of the cytidine deaminases APOBEC3C and APOBEC3D. Following gemcitabine treatment, …
Here, to define the cancer cell response to gemcitabine, we performed genome-scale CRISPR-Cas9 chemical-genetic screens in PDAC cells and fo …
APOBEC3D and APOBEC3F potently promote HIV-1 diversification and evolution in humanized mouse model.
Sato K, Takeuchi JS, Misawa N, Izumi T, Kobayashi T, Kimura Y, Iwami S, Takaori-Kondo A, Hu WS, Aihara K, Ito M, An DS, Pathak VK, Koyanagi Y. Sato K, et al. PLoS Pathog. 2014 Oct 16;10(10):e1004453. doi: 10.1371/journal.ppat.1004453. eCollection 2014 Oct. PLoS Pathog. 2014. PMID: 25330146 Free PMC article.
Several APOBEC3 proteins, particularly APOBEC3D, APOBEC3F, and APOBEC3G, induce G-to-A hypermutations in HIV-1 genome, and abrogate viral replication in experimental systems, but their relative contributions to controlling viral replication and viral genetic variation in v …
Several APOBEC3 proteins, particularly APOBEC3D, APOBEC3F, and APOBEC3G, induce G-to-A hypermutations in HIV-1 genome, and abrogate v …
The Pyroptosis-Related Risk Genes APOBEC3D, TNFRSF14, and RAC2 Were Used to Evaluate Prognosis and as Tumor Suppressor Genes in Breast Cancer.
Chen Q, Jun H, Yang C, Yang F, Xu Y. Chen Q, et al. J Oncol. 2022 Aug 25;2022:3625790. doi: 10.1155/2022/3625790. eCollection 2022. J Oncol. 2022. PMID: 36059808 Free PMC article.
Survival analysis results showed that the C2 group had a better prognosis. Then, a three-gene signature (APOBEC3D, TNFRSF14, and RAC2) were created by Lasso regression analysis, which had a good prediction effect in the TCGA-BC and GSE37751 datasets. ...CONCLUSIONS: Based …
Survival analysis results showed that the C2 group had a better prognosis. Then, a three-gene signature (APOBEC3D, TNFRSF14, and RAC2 …
Comprehensive bioinformatics analyses of APOBECs family and identification of APOBEC3D as the unfavorable prognostic biomarker in clear cell renal cell carcinoma.
Zhu Z, Ji X, Zhu W, Cai T, Xu C, Huang C, He S, Gong Y, Li X, Lin J, Zhou L. Zhu Z, et al. J Cancer. 2021 Oct 17;12(23):7101-7110. doi: 10.7150/jca.61972. eCollection 2021. J Cancer. 2021. PMID: 34729111 Free PMC article.
We then constructed nomograms to predict the prognosis of ccRCC patients better. Afterward, we further focused on APOBEC3D in our data on ccRCC specimens. The APOBEC3D should be extensively studied in ccRCC in the future. ...Next, a nomogram was created integrating …
We then constructed nomograms to predict the prognosis of ccRCC patients better. Afterward, we further focused on APOBEC3D in our dat …
Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.
Hultquist JF, Lengyel JA, Refsland EW, LaRue RS, Lackey L, Brown WL, Harris RS. Hultquist JF, et al. J Virol. 2011 Nov;85(21):11220-34. doi: 10.1128/JVI.05238-11. Epub 2011 Aug 10. J Virol. 2011. PMID: 21835787 Free PMC article.
In addition to APOBEC3G, we find that three other human APOBEC3 proteins, APOBEC3D, APOBEC3F, and APOBEC3H, are all potent HIV-1 restriction factors. ...These data strongly implicate a combination of four APOBEC3 proteins--APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H- …
In addition to APOBEC3G, we find that three other human APOBEC3 proteins, APOBEC3D, APOBEC3F, and APOBEC3H, are all potent HIV-1 rest …
APOBEC Enzymes as Targets for Virus and Cancer Therapy.
Olson ME, Harris RS, Harki DA. Olson ME, et al. Cell Chem Biol. 2018 Jan 18;25(1):36-49. doi: 10.1016/j.chembiol.2017.10.007. Epub 2017 Nov 16. Cell Chem Biol. 2018. PMID: 29153851 Free PMC article. Review.
Human DNA cytosine-to-uracil deaminases catalyze mutations in both pathogen and cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human immunodeficiency virus 1 (HIV-1) infection in cells deficient in the viral infectivity factor (Vif), and have the pot …
Human DNA cytosine-to-uracil deaminases catalyze mutations in both pathogen and cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and A …
Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases.
Siriwardena SU, Chen K, Bhagwat AS. Siriwardena SU, et al. Chem Rev. 2016 Oct 26;116(20):12688-12710. doi: 10.1021/acs.chemrev.6b00296. Epub 2016 Sep 1. Chem Rev. 2016. PMID: 27585283 Free PMC article. Review.
Members of the APOBEC3 subfamily in humans (APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H) inhibit infections of viruses such as HIV-1, HBV, and HCV, and retrotransposition of endogenous retroelements through mutagenic and nonmutagenic mechanisms …
Members of the APOBEC3 subfamily in humans (APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H) inhibit infecti …
Dual Functionality of HIV-1 Vif in APOBEC3 Counteraction and Cell Cycle Arrest.
Salamango DJ, Harris RS. Salamango DJ, et al. Front Microbiol. 2021 Jan 12;11:622012. doi: 10.3389/fmicb.2020.622012. eCollection 2020. Front Microbiol. 2021. PMID: 33510734 Free PMC article. Review.
A prime example is the virion infectivity factor, Vif, which hijacks a cellular co-transcription factor (CBF-beta) to recruit a ubiquitin ligase complex (CRL5) to bind and degrade antiviral APOBEC3 enzymes including APOBEC3D (A3D), APOBEC3F (A3F), APOBEC3G (A3G), and APOBE …
A prime example is the virion infectivity factor, Vif, which hijacks a cellular co-transcription factor (CBF-beta) to recruit a ubiquitin li …
45 results