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Page 1
Apcdd1 is a dual BMP/Wnt inhibitor in the developing nervous system and skin.
Vonica A, Bhat N, Phan K, Guo J, Iancu L, Weber JA, Karger A, Cain JW, Wang ECE, DeStefano GM, O'Donnell-Luria AH, Christiano AM, Riley B, Butler SJ, Luria V. Vonica A, et al. Dev Biol. 2020 Aug 1;464(1):71-87. doi: 10.1016/j.ydbio.2020.03.015. Epub 2020 Apr 19. Dev Biol. 2020. PMID: 32320685 Free PMC article.
Here we show that the Bone Morphogenetic Protein (BMP) and Wnt signaling pathways share Apcdd1 as a common inhibitor and that Apcdd1 is a taxon-restricted gene with novel domains and signaling functions. Previously, we showed that Apcdd1 inhibits Wnt signalin …
Here we show that the Bone Morphogenetic Protein (BMP) and Wnt signaling pathways share Apcdd1 as a common inhibitor and that Apcd …
Apcdd1 stimulates oligodendrocyte differentiation after white matter injury.
Lee HK, Laug D, Zhu W, Patel JM, Ung K, Arenkiel BR, Fancy SP, Mohila C, Deneen B. Lee HK, et al. Glia. 2015 Oct;63(10):1840-9. doi: 10.1002/glia.22848. Epub 2015 May 6. Glia. 2015. PMID: 25946682 Free PMC article.
Analysis of Apcdd1 expression revealed dynamic expression during OL development, where its expression is upregulated during differentiation. Functional studies using ex vivo and in vitro OL systems revealed that Apcdd1 promotes OL differentiation, suppresses Wnt sig …
Analysis of Apcdd1 expression revealed dynamic expression during OL development, where its expression is upregulated during different …
Structure of WNT inhibitor adenomatosis polyposis coli down-regulated 1 (APCDD1), a cell-surface lipid-binding protein.
Hsieh FL, Chang TH, Gabelli SB, Nathans J. Hsieh FL, et al. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2217096120. doi: 10.1073/pnas.2217096120. Epub 2023 May 8. Proc Natl Acad Sci U S A. 2023. PMID: 37155902 Free PMC article.
One such regulator is adenomatosis polyposis coli down-regulated 1 (APCDD1), a conserved single-span transmembrane protein. In response to WNT signaling in a variety of tissues, APCDD1 transcripts are highly up-regulated. ...This work suggests that APCDD1 fun …
One such regulator is adenomatosis polyposis coli down-regulated 1 (APCDD1), a conserved single-span transmembrane protein. In respon …
The role of APCDD1 in epithelial rearrangement in tooth morphogenesis.
Neupane S, Sohn WJ, Gwon GJ, Kim KR, Lee S, An CH, Suh JY, Shin HI, Yamamoto H, Cho SW, Lee Y, Kim JY. Neupane S, et al. Histochem Cell Biol. 2015 Oct;144(4):377-87. doi: 10.1007/s00418-015-1345-z. Epub 2015 Jul 14. Histochem Cell Biol. 2015. PMID: 26170146
Adenomatosis polyposis coli downregulated 1 (APCDD1), a negative regulator of Wnt signaling, was examined to understand detailed mechanisms underlying Wnt signaling tooth development. ...In vitro organ cultivation by using Apcdd1 antisense oligodeoxynucleotides was …
Adenomatosis polyposis coli downregulated 1 (APCDD1), a negative regulator of Wnt signaling, was examined to understand detailed mech …
APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex.
Shimomura Y, Agalliu D, Vonica A, Luria V, Wajid M, Baumer A, Belli S, Petukhova L, Schinzel A, Brivanlou AH, Barres BA, Christiano AM. Shimomura Y, et al. Nature. 2010 Apr 15;464(7291):1043-7. doi: 10.1038/nature08875. Nature. 2010. PMID: 20393562 Free PMC article.
Functional studies show that APCDD1 inhibits Wnt signalling in a cell-autonomous manner and functions upstream of beta-catenin. ...These findings describe a novel inhibitor of the Wnt signalling pathway with an essential role in human hair growth. As APCDD1 is expre …
Functional studies show that APCDD1 inhibits Wnt signalling in a cell-autonomous manner and functions upstream of beta-catenin. ...Th …
The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation of Retinal Blood Vessels.
Mazzoni J, Smith JR, Shahriar S, Cutforth T, Ceja B, Agalliu D. Mazzoni J, et al. Neuron. 2017 Dec 6;96(5):1055-1069.e6. doi: 10.1016/j.neuron.2017.10.025. Epub 2017 Nov 16. Neuron. 2017. PMID: 29154126 Free PMC article.
Apcdd1-deficient mice exhibit a transient increase in vessel density at ages P10-P12 due to delayed vessel pruning. Moreover, Apcdd1 mutant endothelial cells precociously form the paracellular component of the barrier. ...
Apcdd1-deficient mice exhibit a transient increase in vessel density at ages P10-P12 due to delayed vessel pruning. Moreover, Apcd …
Whole Exome Sequencing Identifies APCDD1 and HDAC5 Genes as Potentially Cancer Predisposing in Familial Colorectal Cancer.
Skopelitou D, Miao B, Srivastava A, Kumar A, Kuswick M, Dymerska D, Paramasivam N, Schlesner M, Lubinski J, Hemminki K, Försti A, Bandapalli OR. Skopelitou D, et al. Int J Mol Sci. 2021 Feb 12;22(4):1837. doi: 10.3390/ijms22041837. Int J Mol Sci. 2021. PMID: 33673279 Free PMC article. Clinical Trial.
Sanger sequencing confirmed the variants segregating with the disease and Taqman assays revealed 8 additional APCDD1 variants in a cohort of 1705 familial CRC patients and no further HDAC5 variants. Proliferation assays indicated an insignificant proliferative impact for t …
Sanger sequencing confirmed the variants segregating with the disease and Taqman assays revealed 8 additional APCDD1 variants in a co …
The WNT inhibitor APCDD1 sustains the expression of beta-catenin during the osteogenic differentiation of human dental follicle cells.
Viale-Bouroncle S, Klingelhöffer C, Ettl T, Morsczeck C. Viale-Bouroncle S, et al. Biochem Biophys Res Commun. 2015 Feb 13;457(3):314-7. doi: 10.1016/j.bbrc.2014.12.107. Epub 2015 Jan 12. Biochem Biophys Res Commun. 2015. PMID: 25592970
In addition, a depletion of APCDD1 inhibits the expression of osteogenic markers such as RUNX2 and decreased the matrix mineralization. ...In conclusion, our data disclosed an unusual role of APCDD1 in DFCs during the osteogenic differentiation. APCDD1 sustai …
In addition, a depletion of APCDD1 inhibits the expression of osteogenic markers such as RUNX2 and decreased the matrix mineralizatio …
A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve.
Siguero-Álvarez M, Salguero-Jiménez A, Grego-Bessa J, de la Barrera J, MacGrogan D, Prados B, Sánchez-Sáez F, Piñeiro-Sabarís R, Felipe-Medina N, Torroja C, Gómez MJ, Sabater-Molina M, Escribá R, Richaud-Patin I, Iglesias-García O, Sbroggio M, Callejas S, O'Regan DP, McGurk KA, Dopazo A, Giovinazzo G, Ibañez B, Monserrat L, Pérez-Pomares JM, Sánchez-Cabo F, Pendas AM, Raya A, Gimeno-Blanes JR, de la Pompa JL. Siguero-Álvarez M, et al. Circulation. 2023 Jan 3;147(1):47-65. doi: 10.1161/CIRCULATIONAHA.121.058767. Epub 2022 Nov 3. Circulation. 2023. PMID: 36325906 Free article.
We also generated mice separately carrying these MIB1 mutations plus 5 additional cosegregating variants in the ASXL3, APCDD1, TMX3, CEP192, and BCL7A genes identified in these LVNC families by whole exome sequencing. ...Whole exome sequencing of LVNC families revealed sin …
We also generated mice separately carrying these MIB1 mutations plus 5 additional cosegregating variants in the ASXL3, APCDD1, TMX3, …
60 results