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1993 3
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263 results

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Page 1
Recessive APC2 missense variants associated with epilepsies without neurodevelopmental disorders.
Jin L, Li Y, Luo S, Peng Q, Zhai QX, Zhai JX, Gao LD, Guo JJ, Song W, Yi YH, He N, Chen YJ. Jin L, et al. Seizure. 2023 Oct;111:172-177. doi: 10.1016/j.seizure.2023.08.008. Epub 2023 Aug 18. Seizure. 2023. PMID: 37657306
Previously, the APC2 variants have been reported to be associated with cortical dysplasia and intellectual disability. ...SIGNIFICANCE: This study suggests that APC2 is potentially associated with epilepsy without brain malformation/intellectual disability. ...
Previously, the APC2 variants have been reported to be associated with cortical dysplasia and intellectual disability. ...SIGNIFICANC …
APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression.
Mohamed NE, Hay T, Reed KR, Smalley MJ, Clarke AR. Mohamed NE, et al. BMC Cancer. 2019 Jul 10;19(1):677. doi: 10.1186/s12885-019-5867-y. BMC Cancer. 2019. PMID: 31291912 Free PMC article.
Here, we demonstrate essential roles of APC2 in regulating ovarian WNT signalling and ovarian homeostasis. METHODS: A detailed analysis of ovarian histology, gene expression, ovulation and hormone levels was carried out in 10 week old and in aged constitutive APC2-k …
Here, we demonstrate essential roles of APC2 in regulating ovarian WNT signalling and ovarian homeostasis. METHODS: A detailed analys …
APC2 controls dendrite development by promoting microtubule dynamics.
Kahn OI, Schätzle P, van de Willige D, Tas RP, Lindhout FW, Portegies S, Kapitein LC, Hoogenraad CC. Kahn OI, et al. Nat Commun. 2018 Jul 17;9(1):2773. doi: 10.1038/s41467-018-05124-5. Nat Commun. 2018. PMID: 30018294 Free PMC article.
Depletion of APC2 reduces the plus end dynamics of minus-end-out oriented microtubules, increases microtubule sliding, and causes defects in dendritic morphology. We propose a model in which APC2 regulates dendrite development by promoting dynamics of minus-end-out …
Depletion of APC2 reduces the plus end dynamics of minus-end-out oriented microtubules, increases microtubule sliding, and causes def …
Host-mediated ubiquitination of a mycobacterial protein suppresses immunity.
Wang L, Wu J, Li J, Yang H, Tang T, Liang H, Zuo M, Wang J, Liu H, Liu F, Chen J, Liu Z, Wang Y, Peng C, Wu X, Zheng R, Huang X, Ran Y, Rao Z, Ge B. Wang L, et al. Nature. 2020 Jan;577(7792):682-688. doi: 10.1038/s41586-019-1915-7. Epub 2020 Jan 15. Nature. 2020. PMID: 31942069
Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features.
Almuriekhi M, Shintani T, Fahiminiya S, Fujikawa A, Kuboyama K, Takeuchi Y, Nawaz Z, Nadaf J, Kamel H, Kitam AK, Samiha Z, Mahmoud L, Ben-Omran T, Majewski J, Noda M. Almuriekhi M, et al. Cell Rep. 2015 Mar 10;10(9):1585-1598. doi: 10.1016/j.celrep.2015.02.011. Epub 2015 Mar 5. Cell Rep. 2015. PMID: 25753423 Free article.
Apc2-deficient (Apc2(-/-)) mice exhibited impaired learning and memory abilities along with an abnormal head shape. Endogenous Apc2 expression was downregulated by the knockdown of Nsd1, indicating that APC2 is a downstream effector of NSD1 in neurons. …
Apc2-deficient (Apc2(-/-)) mice exhibited impaired learning and memory abilities along with an abnormal head shape. Endogenous …
CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I.
Zhou CJ, Wang XY, Dong YH, Wang DH, Han Z, Zhang XJ, Sun QY, Carroll J, Liang CG. Zhou CJ, et al. Nat Commun. 2022 Dec 13;13(1):7732. doi: 10.1038/s41467-022-35461-5. Nat Commun. 2022. PMID: 36513638 Free PMC article.
Importantly, acute DRP1 depletion activates separase by initiating cyclinB1 and securin degradation during the metaphase-to-anaphase transition. Finally, we demonstrate that DRP1 is bound to APC2 to restrain the E3 ligase activity of APC/C. In conclusion, DRP1 is a CENP-F- …
Importantly, acute DRP1 depletion activates separase by initiating cyclinB1 and securin degradation during the metaphase-to-anaphase transit …
APC2 associates with the actin cortex through a multipart mechanism to regulate cortical actin organization and dynamics in the Drosophila ovary.
Molinar-Inglis O, Oliver SL, Rudich P, Kunttas E, McCartney BM. Molinar-Inglis O, et al. Cytoskeleton (Hoboken). 2018 Jul;75(7):323-335. doi: 10.1002/cm.21471. Epub 2018 Sep 21. Cytoskeleton (Hoboken). 2018. PMID: 30019417 Free PMC article.
To understand how APC2 influences these properties of the actin cortex, we investigated the mechanisms controlling the cortical localization of APC2 in S2 cultured cells. We previously showed that the N-terminal half of APC2 containing the Armadillo repeats a …
To understand how APC2 influences these properties of the actin cortex, we investigated the mechanisms controlling the cortical local …
APC2 plays an essential role in axonal projections through the regulation of microtubule stability.
Shintani T, Ihara M, Tani S, Sakuraba J, Sakuta H, Noda M. Shintani T, et al. J Neurosci. 2009 Sep 16;29(37):11628-40. doi: 10.1523/JNEUROSCI.2394-09.2009. J Neurosci. 2009. PMID: 19759310 Free PMC article.
APC2 is preferentially expressed in the nervous system from early developmental stages through to adulthood. ...Overexpression of APC2 in cultured cells induced the stabilization of microtubules, whereas the knockdown of APC2 in chick retinas with specific sh …
APC2 is preferentially expressed in the nervous system from early developmental stages through to adulthood. ...Overexpression of …
Human APC2 localization and allelic imbalance.
Jarrett CR, Blancato J, Cao T, Bressette DS, Cepeda M, Young PE, King CR, Byers SW. Jarrett CR, et al. Cancer Res. 2001 Nov 1;61(21):7978-84. Cancer Res. 2001. PMID: 11691822
When overexpressed in SKOV3 ovarian cancer cells, which express low levels of APC2, exogenous APC2 localized to the Golgi apparatus, actin-containing structures, and occasionally to microtubules. Antibodies against the NH2 terminus of human APC2 show that end …
When overexpressed in SKOV3 ovarian cancer cells, which express low levels of APC2, exogenous APC2 localized to the Golgi appa …
APC2(CDH1) negatively regulates agrin signaling by promoting the ubiquitination and proteolytic degradation of DOK7.
Chen A, Bai L, Zhong K, Shu X, Wang A, Xiao Y, Zhang K, Shen C. Chen A, et al. FASEB J. 2020 Sep;34(9):12009-12023. doi: 10.1096/fj.202000485R. Epub 2020 Jul 20. FASEB J. 2020. PMID: 32687671
Here, we show that APC2 is enriched at post-synapse of NMJs in postmitotic myotubes. In response to agrin stimulation, APC2 negatively regulates AChR clustering by promoting the ubiquitination of DOK7 at lysine 243 for its proteolytic degradation, which relies on Mu …
Here, we show that APC2 is enriched at post-synapse of NMJs in postmitotic myotubes. In response to agrin stimulation, APC2 ne …
263 results