ADGB variants cause asthenozoospermia and male infertility.
Qu R, Zhang Z, Wu L, Li Q, Mu J, Zhao L, Yan Z, Wang W, Zeng Y, Liu R, Dong J, Li Q, Sun X, Wang L, Sang Q, Chen B, Kuang Y.
Qu R, et al.
Hum Genet. 2023 Jun;142(6):735-748. doi: 10.1007/s00439-023-02546-0. Epub 2023 Mar 30.
Hum Genet. 2023.
PMID: 36995441
The variants disrupted the binding of ADGB to calmodulin. Adgb(-/-) male mice were infertile due to reduced sperm concentration (< 1 10(6) /mL) and motility. ...Through mass spectrometry, we identified 42 candidate proteins that are involved in sperm assembly, fl …
The variants disrupted the binding of ADGB to calmodulin. Adgb(-/-) male mice were infertile due to reduced sperm concentratio …