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ADGB variants cause asthenozoospermia and male infertility.
Qu R, Zhang Z, Wu L, Li Q, Mu J, Zhao L, Yan Z, Wang W, Zeng Y, Liu R, Dong J, Li Q, Sun X, Wang L, Sang Q, Chen B, Kuang Y. Qu R, et al. Hum Genet. 2023 Jun;142(6):735-748. doi: 10.1007/s00439-023-02546-0. Epub 2023 Mar 30. Hum Genet. 2023. PMID: 36995441
The variants disrupted the binding of ADGB to calmodulin. Adgb(-/-) male mice were infertile due to reduced sperm concentration (< 1 10(6) /mL) and motility. ...Through mass spectrometry, we identified 42 candidate proteins that are involved in sperm assembly, fl …
The variants disrupted the binding of ADGB to calmodulin. Adgb(-/-) male mice were infertile due to reduced sperm concentratio …
A molecular atlas of the human postmenopausal fallopian tube and ovary from single-cell RNA and ATAC sequencing.
Lengyel E, Li Y, Weigert M, Zhu L, Eckart H, Javellana M, Ackroyd S, Xiao J, Olalekan S, Glass D, Iyer S, Krishnan R, Bilecz AJ, Lastra R, Chen M, Basu A. Lengyel E, et al. Cell Rep. 2022 Dec 20;41(12):111838. doi: 10.1016/j.celrep.2022.111838. Cell Rep. 2022. PMID: 36543131 Free article.
FT epithelial cells express multiple ovarian cancer risk-associated genes (CCDC170, RND3, TACC2, STK33, and ADGB) and show active communication between fimbrial epithelial cells and ovarian stromal cells. ...
FT epithelial cells express multiple ovarian cancer risk-associated genes (CCDC170, RND3, TACC2, STK33, and ADGB) and show active com …
Androglobin, a chimeric mammalian globin, is required for male fertility.
Keppner A, Correia M, Santambrogio S, Koay TW, Maric D, Osterhof C, Winter DV, Clerc A, Stumpe M, Chalmel F, Dewilde S, Odermatt A, Kressler D, Hankeln T, Wenger RH, Hoogewijs D. Keppner A, et al. Elife. 2022 Jun 14;11:e72374. doi: 10.7554/eLife.72374. Elife. 2022. PMID: 35700329 Free PMC article.
Finally, in vitro data suggest that Adgb contributes to Sept10 proteolysis in a calmodulin-dependent manner. Collectively, our results provide evidence that Adgb is essential for murine spermatogenesis and further suggest that Adgb is required for sperm head …
Finally, in vitro data suggest that Adgb contributes to Sept10 proteolysis in a calmodulin-dependent manner. Collectively, our result …
CRISPR Activator Approaches to Study Endogenous Androglobin Gene Regulation.
Koay TW, Schödel J, Hoogewijs D. Koay TW, et al. Methods Mol Biol. 2023;2648:167-185. doi: 10.1007/978-1-0716-3080-8_11. Methods Mol Biol. 2023. PMID: 37039991
Whereas abundant expression of ADGB was initially found to be mainly restricted to cells in the postmeiotic stages of spermatogenesis, more recent RNA-Seq-based expression analysis data revealed that ADGB is detectable in cells carrying motile cilia or flagella. Thi …
Whereas abundant expression of ADGB was initially found to be mainly restricted to cells in the postmeiotic stages of spermatogenesis …
Androglobin gene expression patterns and FOXJ1-dependent regulation indicate its functional association with ciliogenesis.
Koay TW, Osterhof C, Orlando IMC, Keppner A, Andre D, Yousefian S, Suárez Alonso M, Correia M, Markworth R, Schödel J, Hankeln T, Hoogewijs D. Koay TW, et al. J Biol Chem. 2021 Jan-Jun;296:100291. doi: 10.1016/j.jbc.2021.100291. Epub 2021 Jan 13. J Biol Chem. 2021. PMID: 33453283 Free PMC article.
Androglobin (ADGB) represents the latest addition to the globin superfamily in metazoans. ...Reporter gene assays revealed that FOXJ1 indeed substantially enhanced luciferase activity driven by the ADGB promoter. ChIP assays confirmed binding of FOXJ1 to the endogen …
Androglobin (ADGB) represents the latest addition to the globin superfamily in metazoans. ...Reporter gene assays revealed that FOXJ1 …
Congenital heart defects caused by FOXJ1.
Padua MB, Helm BM, Wells JR, Smith AM, Bellchambers HM, Sridhar A, Ware SM. Padua MB, et al. Hum Mol Genet. 2023 Jul 4;32(14):2335-2346. doi: 10.1093/hmg/ddad065. Hum Mol Genet. 2023. PMID: 37158461
Functional experiments show that FOXJ1 c.784_799dup; p.Glu267Glyfs*12, unlike FOXJ1, fails to induce ectopic cilia in frog epidermis in vivo or to activate the ADGB promoter, a downstream target of FOXJ1 in cilia, in transactivation assays in vitro. ...
Functional experiments show that FOXJ1 c.784_799dup; p.Glu267Glyfs*12, unlike FOXJ1, fails to induce ectopic cilia in frog epidermis in vivo …
Whole-exome sequencing identifies ADGB as a novel causative gene for male infertility in humans: from motility to fertilization.
Gao Y, Liu L, Tian S, Liu C, Lv M, Wu H, Tang D, Song B, Shen Q, Xu Y, Zhou P, Wei Z, Zhang F, Cao Y, He X. Gao Y, et al. Andrology. 2024 Feb 22. doi: 10.1111/andr.13605. Online ahead of print. Andrology. 2024. PMID: 38385883
OBJECTIVES: In male mice, adgb-knockout has been reported to cause male infertility with spermatogenesis defects involving flagella and acrosome. ...We found one homozygous frameshift ADGB variant (NM_024694.4: c.2801_2802del:p.K934Rfs*33), one homozygous missense …
OBJECTIVES: In male mice, adgb-knockout has been reported to cause male infertility with spermatogenesis defects involving flagella a …
Androglobin knockdown inhibits growth of glioma cell lines.
Huang B, Lu YS, Li X, Zhu ZC, Li K, Liu JW, Zheng J, Hu ZL. Huang B, et al. Int J Clin Exp Pathol. 2014 Apr 15;7(5):2179-84. eCollection 2014. Int J Clin Exp Pathol. 2014. PMID: 24966926 Free PMC article.
In the present study, we show that ADGB plays an oncogene role in glioma. Lentiviral vector mediated ADGB knockdown inhibited the proliferation of glioma cell lines determined by MTT assay and colony formation assay. ...These findings suggest ADGB is involved …
In the present study, we show that ADGB plays an oncogene role in glioma. Lentiviral vector mediated ADGB knockdown inhibited …
Composition and function of the C1b/C1f region in the ciliary central apparatus.
Joachimiak E, Osinka A, Farahat H, Świderska B, Sitkiewicz E, Poprzeczko M, Fabczak H, Wloga D. Joachimiak E, et al. Sci Rep. 2021 Jun 3;11(1):11760. doi: 10.1038/s41598-021-90996-9. Sci Rep. 2021. PMID: 34083607 Free PMC article.
We show that in the model ciliate Tetrahymena thermophila, C1b/C1f contains several evolutionarily conserved proteins: Spef2A, Cfap69, Cfap246/LRGUK, Adgb/androglobin, and a ciliate-specific protein Tt170/TTHERM_00205170. Deletion of genes encoding either Spef2A or Cfap69 …
We show that in the model ciliate Tetrahymena thermophila, C1b/C1f contains several evolutionarily conserved proteins: Spef2A, Cfap69, Cfap2 …
Abundant expression of herpes simplex virus glycoprotein gB using an adenovirus vector.
Johnson DC, Ghosh-Choudhury G, Smiley JR, Fallis L, Graham FL. Johnson DC, et al. Virology. 1988 May;164(1):1-14. doi: 10.1016/0042-6822(88)90613-7. Virology. 1988. PMID: 2834864
The gB gene was coupled to the SV40 early promoter and inserted into the E3 region of two adenovirus vectors, one in which the E1 region was deleted (AdgB-1) and another which contained E1 sequences (AdgB-2). In AdgB-1 the orientation of the chimeric gB-SV40 …
The gB gene was coupled to the SV40 early promoter and inserted into the E3 region of two adenovirus vectors, one in which the E1 region was …
34 results