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Arabidopsis AAR2, a conserved splicing factor in eukaryotes, acts in microRNA biogenesis.
Fan L, Gao B, Xu Y, Flynn N, Le B, You C, Li S, Achkar N, Manavella PA, Yang Z, Chen X. Fan L, et al. Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2208415119. doi: 10.1073/pnas.2208415119. Epub 2022 Oct 3. Proc Natl Acad Sci U S A. 2022. PMID: 36191209 Free PMC article.
AAR2 interacts with the microprocessor component hyponastic leaves 1 (HYL1) in the cytoplasm, nucleus, and dicing bodies. ...Taken together, our findings reveal a dual role of AAR2 in miRNA biogenesis and pre-messenger RNA splicing....
AAR2 interacts with the microprocessor component hyponastic leaves 1 (HYL1) in the cytoplasm, nucleus, and dicing bodies. ...Taken to …
Crystallization and biochemical characterization of the human spliceosomal Aar2-Prp8(RNaseH) complex.
Santos K, Preussner M, Heroven AC, Weber G. Santos K, et al. Acta Crystallogr F Struct Biol Commun. 2015 Nov;71(Pt 11):1421-8. doi: 10.1107/S2053230X15019202. Epub 2015 Oct 23. Acta Crystallogr F Struct Biol Commun. 2015. PMID: 26527271 Free PMC article.
Aar2p therefore prevents premature spliceosome activation and its functions are regulated by reversible phosphorylation. To date, little is known about the hypothetical human Aar2 (hsAar2) orthologue C20ORF4. This study identifies C20ORF4 (i) as part of the HeLa proteome b …
Aar2p therefore prevents premature spliceosome activation and its functions are regulated by reversible phosphorylation. To date, little is …
AAR2, a gene for splicing pre-mRNA of the MATa1 cistron in cell type control of Saccharomyces cerevisiae.
Nakazawa N, Harashima S, Oshima Y. Nakazawa N, et al. Mol Cell Biol. 1991 Nov;11(11):5693-700. doi: 10.1128/mcb.11.11.5693-5700.1991. Mol Cell Biol. 1991. PMID: 1922071 Free PMC article.
Cells of the aar2 mutant and the aar2 disruptant also show a growth defect. A DNA fragment complementing the aar2 mutation contains an open reading frame consisting of 355 amino acid codons. ...Thus, the AAR2 gene is involved in splicing pre-mRNA of th …
Cells of the aar2 mutant and the aar2 disruptant also show a growth defect. A DNA fragment complementing the aar2 mutat …
Structural and functional investigation of the human snRNP assembly factor AAR2 in complex with the RNase H-like domain of PRPF8.
Preussner M, Santos KF, Alles J, Heroven C, Heyd F, Wahl MC, Weber G. Preussner M, et al. Acta Crystallogr D Struct Biol. 2022 Nov 1;78(Pt 11):1373-1383. doi: 10.1107/S2059798322009755. Epub 2022 Oct 27. Acta Crystallogr D Struct Biol. 2022. PMID: 36322420 Free PMC article.
Based on the structure of the AAR2-PRPF8 RH complex, the importance of the interacting regions and residues was probed and AAR2 variants were designed that failed to stably bind PRPF8 in vitro. ...These findings extend the picture of AAR2 PRP8 interaction fro …
Based on the structure of the AAR2-PRPF8 RH complex, the importance of the interacting regions and residues was probed and AAR2 …
Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus.
Rehling D, Scaletti ER, Rozman Grinberg I, Lundin D, Sahlin M, Hofer A, Sjöberg BM, Stenmark P. Rehling D, et al. Biochemistry. 2022 Jan 18;61(2):92-106. doi: 10.1021/acs.biochem.1c00503. Epub 2021 Dec 23. Biochemistry. 2022. PMID: 34941255 Free PMC article.
Specifically, AaR1 contains a beta-hairpin hook structure at the dimer interface, which has an interesting pi-stacking interaction absent in other members of the NrdAh subclass, and its ATP cone houses two ATP molecules. We determined structures of two AaR2 proteins: one p …
Specifically, AaR1 contains a beta-hairpin hook structure at the dimer interface, which has an interesting pi-stacking interaction absent in …
CryoEM of RUVBL1-RUVBL2-ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8.
Serna M, González-Corpas A, Cabezudo S, López-Perrote A, Degliesposti G, Zarzuela E, Skehel JM, Muñoz J, Llorca O. Serna M, et al. Nucleic Acids Res. 2022 Jan 25;50(2):1128-1146. doi: 10.1093/nar/gkab1267. Nucleic Acids Res. 2022. PMID: 34951455 Free PMC article.
We characterized the interactions between R2TP, PRPF8, ZNHIT2, ECD and AAR2 proteins. Interestingly, PRPF8 makes a direct interaction with R2TP and this complex can incorporate ZNHIT2 and other proteins involved in the biogenesis of PRPF8 such as ECD and AAR2. ...
We characterized the interactions between R2TP, PRPF8, ZNHIT2, ECD and AAR2 proteins. Interestingly, PRPF8 makes a direct interaction …
Integrative Analysis of Nanopore and Illumina Sequencing Reveals Alternative Splicing Complexity in Pig Longissimus Dorsi Muscle.
Shu Z, Wang L, Wang J, Zhang L, Hou X, Yan H, Wang L. Shu Z, et al. Front Genet. 2022 Apr 11;13:877646. doi: 10.3389/fgene.2022.877646. eCollection 2022. Front Genet. 2022. PMID: 35480309 Free PMC article.
Moreover, co-expression and protein-protein interaction (PPI) analysis indicated that several genes (MRPL27, AAR2, PYGM, PSMD4, SCNM1, and HNRNPDL) may be related to intramuscular fat. ...
Moreover, co-expression and protein-protein interaction (PPI) analysis indicated that several genes (MRPL27, AAR2, PYGM, PSMD4, SCNM1 …
Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites.
Barthel T, Wollenhaupt J, Lima GMA, Wahl MC, Weiss MS. Barthel T, et al. J Med Chem. 2022 Nov 10;65(21):14630-14641. doi: 10.1021/acs.jmedchem.2c01165. Epub 2022 Oct 19. J Med Chem. 2022. PMID: 36260741
Here, we present the crystallographic screening of our 1000-plus-compound F2X-Universal Library against the complex of the yeast spliceosomal Prp8 RNaseH-like domain and the snRNP assembly factor Aar2. The observed 269 hits are distributed over 10 distinct binding sites on …
Here, we present the crystallographic screening of our 1000-plus-compound F2X-Universal Library against the complex of the yeast spliceosoma …
The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2p.
Gottschalk A, Kastner B, Lührmann R, Fabrizio P. Gottschalk A, et al. RNA. 2001 Nov;7(11):1554-65. RNA. 2001. PMID: 11720285 Free PMC article.
Aar2p is associated exclusively with this simple form of the U5 snRNP (Aar2-U5), but not with the [U4/U6.U5] tri-snRNP or spliceosomal complexes. ...Thus, the basic structural scaffold of the Aar2-U5 snRNP seems to be essentially determined by Prp8p, Snu114p, and th …
Aar2p is associated exclusively with this simple form of the U5 snRNP (Aar2-U5), but not with the [U4/U6.U5] tri-snRNP or spliceosoma …
26 results