Regulation of inositol lipid kinases by Rho and Rac

Curr Opin Genet Dev. 1998 Feb;8(1):63-7. doi: 10.1016/s0959-437x(98)80063-4.

Abstract

Rho and Rac small GTPases associate with type-I phosphatidylinositol 4-phosphate 5-kinase to regulate the production of phosphatidylinositol 4,5-bisphosphate. This lipid appears to mediate some of the effects of Rho and Rac on the actin cytoskeleton. The genes for several type-I phosphatidylinositol 4-phosphate 5-kinases have been cloned recently but it is not known which one interacts with Rho and/or Rac. Rho family GTPases also interact with phosphatidylinositol 3-kinase, though this kinase can be either upstream or downstream of the GTPases depending upon the system.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • GTP-Binding Proteins / metabolism*
  • Humans
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism*
  • rac GTP-Binding Proteins
  • rhoA GTP-Binding Protein

Substances

  • Phosphatidylinositol 3-Kinases
  • Phosphotransferases (Alcohol Group Acceptor)
  • 1-phosphatidylinositol-4-phosphate 5-kinase
  • GTP-Binding Proteins
  • rac GTP-Binding Proteins
  • rhoA GTP-Binding Protein