Localization of the gamma-subunit of the skeletal muscle L-type voltage-dependent calcium channel gene (CACNLG) to human chromosome band 17q24 by in situ hybridization and identification of a polymorphic repetitive DNA sequence at the gene locus

Cytogenet Cell Genet. 1993;64(3-4):227-30. doi: 10.1159/000133583.

Abstract

The skeletal muscle dihydropyridine receptor consists of five subunits and fulfils an essential role in excitation-contraction coupling. A genomic clone for the human gamma subunit was used to map the gene (CACNLG) to chromosome band 17q24 by in situ hybridization. Contained within the gene is a 416-bp polymorphic repetitive DNA element that is potentially useful as a genetic marker.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Calcium Channels / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 17*
  • DNA*
  • Humans
  • In Situ Hybridization
  • Male
  • Molecular Sequence Data
  • Muscles / metabolism*
  • Polymorphism, Genetic*
  • Repetitive Sequences, Nucleic Acid*
  • Sequence Analysis, DNA

Substances

  • Calcium Channels
  • DNA

Associated data

  • GENBANK/X62140
  • GENBANK/X70024
  • GENBANK/X70025
  • GENBANK/X70026
  • GENBANK/X70027
  • GENBANK/X70028
  • GENBANK/X71679
  • GENBANK/X71680
  • GENBANK/Z19587
  • GENBANK/Z19603