Abstract
2-Anilinopurines and 6-anilinopyrimidines bearing 3,4- or 3,5-dichloro substituents in the anilino ring inhibited virus-specific DNA synthesis by human cytomegalovirus (HCMV)-infected human embryonic lung (HEL) cells in culture. In general, active compounds had moderate to low selectivity for viral vs host cell DNA synthesis. Nucleoside and acyclonucleoside analogs of 2-(3,5-dichloroanilino)purines inhibited both HCMV and cellular DNA synthesis at similar concentrations. 2-Amino-4-chloro-6-(3,5-dichloroanilino)pyrimidine and several related compounds inhibited HCMV growth in yield reduction assays at concentrations that were nontoxic to HEL cells.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aniline Compounds / chemistry
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Cell Division / drug effects
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Cell Line
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Cytomegalovirus / drug effects*
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Cytomegalovirus / enzymology
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Cytomegalovirus / physiology
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DNA-Directed DNA Polymerase / metabolism
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Halogens / chemistry
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Humans
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Purine Nucleosides / chemistry
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Purine Nucleosides / pharmacology*
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Purines / chemistry
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Purines / pharmacology*
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Pyrimidines / chemistry
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Pyrimidines / pharmacology*
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Virus Replication / drug effects
Substances
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Aniline Compounds
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Antiviral Agents
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Halogens
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Purine Nucleosides
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Purines
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Pyrimidines
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DNA-Directed DNA Polymerase
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aniline