Where do the pathogens that cause surgical site infections come from?

Jack A Gilbert; John Alverdy

doi:10.1126/scitranslmed.ado1449

Where do the pathogens that cause surgical site infections come from?

Sci Transl Med. 2024 Apr 10;16(742):eado1449. doi: 10.1126/scitranslmed.ado1449. Epub 2024 Apr 10.

Authors

Jack A Gilbert¹, John Alverdy²

Affiliations

¹ Department of Pediatrics and Scripps Institution of Oceanography, Microbiome and Metagenomics Center, UC San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA.
² Department of Surgery, University of Chicago, 5801 S. Ellis Avenue, Chicago, IL 60637, USA.

PMID: 38598617
DOI: 10.1126/scitranslmed.ado1449

Abstract

A study from Long et al. shows that many pathogens that cause surgical site infections during spine surgery come from the patient's own microbiome, suggesting a paradigm shift in the understanding of surgical site infections that questions the effectiveness of current enhanced sterility and antibiotic protocols.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Humans
Microbiota*
Surgical Wound Infection* / drug therapy

Substances

Anti-Bacterial Agents