Multilineage circuits of regenerative cell states

Janine Gote-Schniering; Herbert B Schiller

doi:10.1016/j.stem.2023.10.006

Multilineage circuits of regenerative cell states

Cell Stem Cell. 2023 Nov 2;30(11):1397-1399. doi: 10.1016/j.stem.2023.10.006.

Authors

Janine Gote-Schniering¹, Herbert B Schiller²

Affiliations

¹ Comprehensive Pneumology Center (CPC) / Institute of Lung Health and Immunity (LHI), Helmholtz Munich; Member of the German Center for Lung Research (DZL), Munich, Germany; Department of Rheumatology and Immunology, Department of Pulmonary Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Lung Precision Medicine Program, Department for BioMedical Research, University of Bern, Bern, Switzerland.
² Comprehensive Pneumology Center (CPC) / Institute of Lung Health and Immunity (LHI), Helmholtz Munich; Member of the German Center for Lung Research (DZL), Munich, Germany; Institute of Experimental Pneumology, LMU University Hospital, Ludwig-Maximilians University, Munich, Germany. Electronic address: herbert.schiller@helmholtz-munich.de.

PMID: 37922876
DOI: 10.1016/j.stem.2023.10.006

Abstract

Regenerating the lungs' architecture after injury requires rebuilding its fibroelastic extracellular matrix scaffold. Konkimalla et al. establish that regenerative cell states (RCSs) of both epithelial and mesenchymal origin are functionally linked and indispensable for this process. Experimental ablation of RCSs causes organ degeneration, whereas their induction causes organ fibrosis.

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MeSH terms

Extracellular Matrix*
Fibrosis
Humans