Neck of the woods: Microbes, memory, and resistance

Endeavour. 2022 Mar-Jun;46(1-2):100821. doi: 10.1016/j.endeavour.2022.100821. Epub 2022 Jul 7.

Abstract

Horizontal Gene Transfer (HGT) is a key mechanism allowing bacteria to enact genetic changes in response to shifting environmental conditions. The swift lateral movement of genes makes possible antibiotic resistance, which is an increasing medical and ultimately cultural problem. There is evidence that HGT also takes place between species. Bacterial DNA appears in the human mitochondrial genome of acute myeloid leukemia (AML) samples. Responding to a recent diagnosis of AML, this creative piece imagines a literary form of HGT. Adjacency is intrinsic to the conceptual and formal concerns of the text. Moving back and forth between essay and poem, between the personal and the planetary, between the real and the imagined, and between the right and left margins of the page, this piece unfolds beside itself, exploring the lateral movement of memory and family history through concerns with antibiotic resistance, illness, writing, and science. While there are no embedded citations or footnotes, a glossary of terms (Appendix 1) follows the main text, and a brief bibliographic essay (Appendix 2) at the end identifies cited sources that correspond to a list of references.

Keywords: Antibiotic resistance; Horizontal Gene Transfer; Literature and science; Memory; Microbes.

MeSH terms

  • Bacteria* / genetics
  • DNA, Bacterial
  • Drug Resistance, Microbial / genetics
  • Gene Transfer, Horizontal*
  • Humans

Substances

  • DNA, Bacterial