Ciliary extracellular vesicles (ciEVs), released from primary cilia, contain functional proteins that play an important role in cilia structure and functions. We have recently shown that ciEVs and cytosolic extracellular vesicles (cyEVs) have unique and distinct biomarkers. While ciEV biomarkers have shown some interactions with known ciliary proteins, little is known about the interaction of ciEV proteins with proteins involved in ciliopathy and neurodegenerative disorders. Here, we reveal for the first time the protein-protein interaction (PPI) between the top five ciEVs biomarkers with ciliopathy and Alzheimer disease (AD) proteins. These results support the growing evidence of the critical physiological roles of cilia in neurodegenerative disorders.
Keywords: Alzheimer disease; Ciliary extracellular vesicles; bioinformatic; biomarkers; ciliopathy disorders; cytosolic extracellular vesicles; ectosome; exosome; neurodegenerative disorders; primary cilia; proteomics.
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.