Diabetes and COVID-19: A pooled analysis related to disease severity and mortality

Seshadri Reddy Varikasuvu; Naveen Dutt; Balachandar Thangappazham; Saurabh Varshney

doi:10.1016/j.pcd.2020.08.015

Diabetes and COVID-19: A pooled analysis related to disease severity and mortality

Prim Care Diabetes. 2021 Feb;15(1):24-27. doi: 10.1016/j.pcd.2020.08.015. Epub 2020 Aug 29.

Authors

Seshadri Reddy Varikasuvu¹, Naveen Dutt², Balachandar Thangappazham³, Saurabh Varshney⁴

Affiliations

¹ Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Deoghar, Jharkhand, India. Electronic address: lifeschemistry@live.com.
² Department of Respiratory Medicine, All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthan, India.
³ Department of Internal Medicine, All India Institute of Medical Sciences (AIIMS), Bibinagar, Telangana, India.
⁴ Professor and Executive Director, All India Institute of Medical Sciences (AIIMS), Deoghar, Jharkhand, India.

Abstract

Globally, COVID-19 has become a major concern for the diabetic community. We conducted a pooled analysis and constructed a forest plot for the association between diabetes and COVID-19 progression in 47 studies. A random effects meta-analysis (Mantel-Haenszel method) was conducted to estimate the outcomes effect size as odds ratios (OR) and 95% confidence intervals (CI) using Review Manager Software version 5.3. COVID-19 patients with diabetes have a significantly higher risk of disease severity (OR=2.20, 95% CI=1.69-2.86, p<0.00001) and associated mortality outcomes (OR=2.52, 95% CI=1.93-3.30, p=<0.00001).

Keywords: COVID-19; Comorbidities; Diabetes.

Publication types

Meta-Analysis
Review

MeSH terms

COVID-19 / epidemiology*
Comorbidity
Diabetes Mellitus / diagnosis
Diabetes Mellitus / epidemiology*
Global Health
Humans
Pandemics*
SARS-CoV-2
Severity of Illness Index
Survival Rate / trends