Organic semiconducting polymer amphiphile for near-infrared-II light-triggered phototheranostics

Chao Yin; Xiaozhen Li; Guohua Wen; Boguang Yang; Yachao Zhang; Xiaoyu Chen; Pengchao Zhao; Shengliang Li; Rui Li; Lidai Wang; Chun-Sing Lee; Liming Bian

doi:10.1016/j.biomaterials.2019.119684

Organic semiconducting polymer amphiphile for near-infrared-II light-triggered phototheranostics

Biomaterials. 2020 Feb:232:119684. doi: 10.1016/j.biomaterials.2019.119684. Epub 2019 Dec 13.

Authors

Chao Yin¹, Xiaozhen Li², Guohua Wen³, Boguang Yang¹, Yachao Zhang³, Xiaoyu Chen¹, Pengchao Zhao¹, Shengliang Li², Rui Li¹, Lidai Wang⁴, Chun-Sing Lee⁵, Liming Bian⁶

Affiliations

¹ Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
² Center of Super-Diamond and Advanced Films (COSDAF), Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong, China.
³ Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China.
⁴ Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China; City University of Hong Kong Shenzhen Research Institute, Yuexing Yi Dao, Nanshan District, Shenzhen, Guangdong, 518057, China. Electronic address: lidawang@cityu.edu.hk.
⁵ Center of Super-Diamond and Advanced Films (COSDAF), Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong, China. Electronic address: apcslee@cityu.edu.hk.
⁶ Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, 518172, China; Center for Novel Biomaterials, Chinese University of Hong Kong, Shatin, 100097, Hong Kong, China. Electronic address: lbian@cuhk.edu.hk.

PMID: 31901503
DOI: 10.1016/j.biomaterials.2019.119684

Abstract

Development of near-infrared-II (NIR-II) light responsive nano-agents with high photothermal stability, high photothermal conversion efficiency (PCE), and excellent biocompatibility for photoacoustic (PA) imaging-guided photothermal therapy (PTT) is of tremendous significance. In spite of the superiority of organic semiconducting polymer nanoparticles (OSPNs) in PA imaging-guided PTT, the limited absorption in the first NIR (NIR-I) window and metastable nanostructure of OSPNs resulting from commonly used preparation methods based on nanoprecipitation or reprecipitation compromise their in vivo phototheranostic performance. Herein we design and synthesize a novel NIR-II absorbing organic semiconducting polymer amphiphile (OSPA) to enhance the structural stability of OSPNs. With prominent optical properties, low toxicity, and a suitable size, OSPA not only efficiently labels and kills cancer cells under NIR-II irradiation but also accumulates at the tumor of living mice upon intravenous injection, allowing efficient NIR-II light-triggered phototheranostics toward tumor. The developed OSPA has promising potential for fabricating multifunctional nanoplatforms to enable multimodal theranostics.

Keywords: Amphiphile; Photoacoustic imaging; Photothermal therapy; Second near-infrared window; Semiconducting polymer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Infrared Rays
Mice
Nanoparticles*
Photoacoustic Techniques*
Phototherapy
Polymers*
Semiconductors
Theranostic Nanomedicine*

Substances

Polymers