Effectiveness of Coelatura aegyptiaca Extract Combination with Atorvastatin on Experimentally Induced Hyperlipidemia in Rats

Ayman Saber Mohamed; Walaa Mohammed Ibrahim; Nashwah Ismail Zaki; Sara Bayoumi Ali; Amel M Soliman

doi:10.1155/2019/9726137

Effectiveness of Coelatura aegyptiaca Extract Combination with Atorvastatin on Experimentally Induced Hyperlipidemia in Rats

Evid Based Complement Alternat Med. 2019 Jan 1:2019:9726137. doi: 10.1155/2019/9726137. eCollection 2019.

Authors

Ayman Saber Mohamed¹, Walaa Mohammed Ibrahim², Nashwah Ismail Zaki³, Sara Bayoumi Ali², Amel M Soliman⁴

Affiliations

¹ Lecturer of Physiology, Zoology Department, Faculty of Science, Cairo University, 12613 Giza, Egypt.
² M.Sc. Student, Zoology Department, Faculty of Science, Cairo University, Egypt.
³ Professor of Physiology, Physiology Department, National Organization for Drug Control and Research, Egypt.
⁴ Professor of Physiology, Zoology Department, Faculty of Science, Cairo University, Egypt.

Abstract

Background: The present study aimed to assess the effectiveness of clam extract in combination with atorvastatin against experimentally hyperlipidemia in rats.

Method: Forty male rats were divided into 5 groups (8 rats /group): control, high fat diet (HFD), atorvastatin (AROR), clam extract (CE), and ATOR + CE.

Results: The treatments with ATOR and /or CE significantly reduced the body weight gain, AST, ALT, ALP, TL, TC, TG, LDL-C, urea, creatinine, and uric acid levels while they increased total proteins, albumin, and HDL-C. The treatment with ATOR only did not cause any significant change in CK and MDA along with antioxidant system, while the treatment with CE alone or with ATOR significantly decreased CK and MDA accompanied by improving the antioxidant system.

Conclusion: Combination of CE extract with atorvastatin improved the hyperlipidemic efficacy and reduced undesirable side effects especially on muscle.