Natural products from anaerobes

J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):375-383. doi: 10.1007/s10295-018-2086-5. Epub 2018 Oct 3.

Abstract

Natural product discovery in the microbial world has historically been biased toward aerobes. Recent in silico analysis demonstrates that genomes of anaerobes encode unexpected biosynthetic potential for natural products, however, chemical data on natural products from the anaerobic world are extremely limited. Here, we review the current body of work on natural products isolated from strictly anaerobic microbes, including recent genome mining efforts to discover polyketides and non-ribosomal peptides from anaerobes. These known natural products of anaerobes have demonstrated interesting molecular scaffolds, biosynthetic logic, and/or biological activities, making anaerobes a promising reservoir for future natural product discovery.

Keywords: Anaerobic organism; Antibiotic; Genome mining; Secondary metabolite.

Publication types

  • Review

MeSH terms

  • Bacteria, Anaerobic / genetics*
  • Bacteria, Anaerobic / metabolism*
  • Biological Products / metabolism*
  • Biosynthetic Pathways / genetics
  • Chromans / chemistry
  • Multigene Family
  • Naphthols / chemistry
  • Peptides / chemistry
  • Phenazines / chemistry
  • Polycyclic Aromatic Hydrocarbons / chemistry
  • Polyketides / chemistry
  • Thioamides / chemistry

Substances

  • Biological Products
  • Chromans
  • Naphthols
  • Peptides
  • Phenazines
  • Polycyclic Aromatic Hydrocarbons
  • Polyketides
  • Thioamides
  • closthioamide
  • clostrubin
  • methanophenazine
  • naphthalecin