A genome-wide net to catch and understand cancer

Sci Transl Med. 2018 Aug 8;10(453):eaat8288. doi: 10.1126/scitranslmed.aat8288.

Author

Neville E Sanjana^{1

2}

Affiliations

¹ New York Genome Center, New York, NY 10013, USA.
² Department of Biology, New York University, New York, NY 10003, USA.

Abstract

Genome-scale forward genetic screens elucidate the genetic basis of therapeutic resistance, tumor evolution, and metastasis in diverse human cancers.

Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
CRISPR-Cas Systems / genetics
Drug Resistance, Neoplasm / genetics
Genome*
Humans
Immunotherapy
Mutation / genetics
Neoplasms / genetics*

Grants and funding