Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3

Circulation. 2018 Feb 27;137(9):975-977. doi: 10.1161/CIRCULATIONAHA.117.031335.
No abstract available

Keywords: ANGPTL3 protein, human; clustered regularly interspaced short palindromic repeats; coronary disease; lipids.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Angiopoietin-Like Protein 3
  • Angiopoietin-like Proteins / genetics*
  • Animals
  • CRISPR-Cas Systems
  • Disease Models, Animal
  • Female
  • Gene Editing*
  • Hyperlipidemias / blood
  • Hyperlipidemias / genetics*
  • Hyperlipidemias / therapy*
  • Lipids / blood*
  • Loss of Function Mutation
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Proprotein Convertase 9 / genetics

Substances

  • Angiopoietin-Like Protein 3
  • Angiopoietin-like Proteins
  • Angptl3 protein, mouse
  • Lipids
  • Pcsk9 protein, mouse
  • Proprotein Convertase 9